2. Signaling Pathways
  3. Apoptosis
  4. TNF Receptor
  5. TNFRSF1A/CD120a Isoform

TNFRSF1A/CD120a

TNFRSF1A/CD120a, also named TNFR1/p55, mediates cellular responses to soluble TNF and forms a high-affinity receptor system for soluble tumor necrosis factor[1]. Mechanistically, TNF-TNFR1 signaling activates NF-κB and MAPK pathways and can also trigger apoptosis or necroptosis, linking inflammatory transcription with regulated cell death[2]. In vascular models, TNFR1 stimulation was sufficient and necessary for TNF-α-induced endothelial permeability, whereas antagonist anti-TNFR1 antibody blocked this response and antagonist anti-TNFR2 antibodies did not[3]. In disease-focused models, Tnfrsf1a mutations associated with TRAPS reduced cell-surface TNFR1 expression and suppressed responsiveness to TNFα, indicating that mutant-receptor biology requires model-specific validation[4]. Compared with TNFR2/CD120b, TNFR1 shows distinct functional output, because TNFR1 accelerated NK-cell death whereas TNFR2 promoted NK-cell accumulation and effector function in infection models[5]. For experimental applications, antagonistic anti-TNFR1 antibodies such as ATROSAB inhibit TNFR1-mediated responses in vitro, and anti-human TNFR1 targeting modulated immune responses in humanized autoimmune disease models[6][7]. - TNFR1/CD120a supports inflammation, endothelial permeability, and regulated cell death pathway studies. - Selective TNFR1 blockade helps separate TNFR1-driven pathology from TNFR2-mediated immune functions.

TNFRSF1A/CD120a Related Products (8):

Cat. No. Product Name Effect Purity
  • HY-126360
    Oxazolone
    		Activator 98.0%
    Oxazolone is a haptenizing agent that induces acute or chronic inflammation of the large intestine and is used to construct models of colitis. Oxazolone can cause Th1/Th2-dependent colitis with weight loss and diarrhea. Oxazolone-induced inflammation can be mitigated by neutralizing anti-IL-4 or anti-TNF-α antibodies or decoy IL-13R2-α-FC proteins.
  • HY-114360A
    Taurohyodeoxycholic acid sodium
    		Inhibitor 99.99%
    Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.
  • HY-P991400
    GSK1995057
    		Antagonist 99.09%
    GSK1995057 is a human monoclonal antibody (mAb) targeting TNFRSF1A. GSK1995057 selectively binds to TNFR1, blocks the binding of TNF-α and LT-α, and does not interfere with TNFR2 signaling. GSK1995057 inhibits the activation of NF-κB, JNK and MAPK pathways, alleviates apoptosis (apoptosis) and inflammatory responses (inhibiting IL-1β, IL-6, IL-10, TNF-α), and prevents viability loss of human nucleus pulposus cells. GSK1995057 inhibits the expression of cytokines and neutrophil adhesion molecules in human pulmonary microvascular endothelial cell monolayers, and reduces inflammatory responses and lung injury symptoms in non-human primates. GSK1995057 forms complexes with HAVH autoantibodies, thereby activating TNFR1 and triggering the release of cytokines and IL-8 in human cells. GSK1995057 can be used in research related to intervertebral disc degeneration and acute lung injury.
  • HY-145498
    HDMAPP triammonium
    		Activator
    HDMAPP triammonium is a potent phosphoantigen in the ammonium form and the pyrophosphate form of (E)-HDMAPP. HDMAPP is also a potent activator of γδ T cells and can induce T cell stimulation in vitro (EC50=0.39 nM, TNF-α).
  • HY-P991401
    GSK2862277
    		Antagonist
    GSK2862277 is a human monoclonal antibody (mAb) targeting TNFRSF1A. GSK2862277 increases neutrophil extracellular trap formation and alveolar macrophage phagocytosis. GSK2862277 can be used in Acute lung injury and Acute Respiratory Distress Syndrome (ARDS) research. Recommended isotype control: VHH-hFc.
  • HY-134028
    Arucadiol
    		Inhibitor
    Arucadiol is a rosane-type diterpenoid anti-inflammatory agent. 5 μM Arucadiol significantly inhibits LPS-induced TNF-α, IL-1β, and IL-8 production (inhibition rates of 39.8%, 44.4%, and 34.5%, respectively). Arucadiol exerts its anti-inflammatory activity by inhibiting the mRNA and protein expression of inflammatory cytokines and can be used in research on inflammation-related cardiovascular diseases such as atherosclerosis. Arucadiol can be naturally extracted from the roots of Salvia miltiorrhiza var. alba.
  • HY-134950
    (E)-C-HDMAPP ammonium
    		Activator
    (E)-C-HDMAPP ammonium, is a potent phosphoantigen in ammonium form as well as a pyrophosphonate form of (E)-HDMAPP. (E)-C-HDMAPP is also an effective activator of γδ-T cells, induces T-cell stimulatory responses in vitro (EC50=0.91 nM for TNF-α release).
  • HY-N10009
    Cudraflavone B
    		Inhibitor
    Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells.