Taurohyodeoxycholic acid sodium

Name: Taurohyodeoxycholic acid sodium
Brand: MedChemExpress
SKU: HY-114360A
Rating: 4.5 (1 reviews)

Cat. No.: HY-114360A Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

For research use only. We do not sell to patients.

Taurohyodeoxycholic acid sodium Chemical Structure

CAS No. : 38411-85-7

Size	Price	Stock	Quantity
50 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Taurohyodeoxycholic acid sodium

•Phytomedicine.2023 Sep:118:154971. [Abstract]

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[4]

IL-6

TNFR1

In Vivo

Taurohyodeoxycholic acid reduces the size and weight of human gallstones in vitro. Taurohyodeoxycholic acid increases bile flow, bile cholesterol secretion and bile lipid secretion in rats. Co-administration of Taurohyodeoxycholic acid and Taurochenodeoxycholic acid prevented Taurohyodeoxycholic acid-induced hepatotoxicity and increased bile flow and bile acid and phospholipid secretion in rats.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

521.69

Formula

C₂₆H₄₄NNaO₆S

CAS No.

38411-85-7

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@]3([H])[C@](C[C@@H]([C@]1([H])C[C@@H](CC2)O)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCC(NCCS(=O)(O[Na])=O)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 62.5 mg/mL (119.80 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9168 mL	9.5842 mL	19.1685 mL
5 mM	0.3834 mL	1.9168 mL	3.8337 mL
10 mM	0.1917 mL	0.9584 mL	1.9168 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (249 KB) HNMR (284 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Roda A, et al. Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the rat. Hepatology. 1998 Feb;27(2):520-5. [Content Brief]

[2]. Angelico M, et al. Dissolution of human cholesterol gallstones in bile salt/lecithin mixtures: effect of bile salt hydrophobicity and various pHs. Scand J Gastroenterol. 1995 Dec;30(12):1178-85. [Content Brief]

[3]. Angelico M, et al. Effect of taurohyodeoxycholic acid, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat. Dig Dis Sci. 1994 Nov;39(11):2389-97. [Content Brief]

[4]. Solmon Kusuma S, et al. Antineoplastic activity of monocrotaline against hepatocellular carcinoma[J]. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 2014, 14(9): 1237-1248.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.9168 mL	9.5842 mL	19.1685 mL	47.9212 mL
	5 mM	0.3834 mL	1.9168 mL	3.8337 mL	9.5842 mL
	10 mM	0.1917 mL	0.9584 mL	1.9168 mL	4.7921 mL
	15 mM	0.1278 mL	0.6389 mL	1.2779 mL	3.1947 mL
	20 mM	0.0958 mL	0.4792 mL	0.9584 mL	2.3961 mL
	25 mM	0.0767 mL	0.3834 mL	0.7667 mL	1.9168 mL
	30 mM	0.0639 mL	0.3195 mL	0.6389 mL	1.5974 mL
	40 mM	0.0479 mL	0.2396 mL	0.4792 mL	1.1980 mL
	50 mM	0.0383 mL	0.1917 mL	0.3834 mL	0.9584 mL
	60 mM	0.0319 mL	0.1597 mL	0.3195 mL	0.7987 mL
	80 mM	0.0240 mL	0.1198 mL	0.2396 mL	0.5990 mL
	100 mM	0.0192 mL	0.0958 mL	0.1917 mL	0.4792 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.