Taurohyodeoxycholic acid (sodium)

Name: Taurohyodeoxycholic acid sodium
Brand: MedChemExpress
SKU: HY-114360A
Rating: 5.0 (2 reviews)

製品番号: HY-114360A 純度: 99.99%: Data Sheet SDS COA 取扱説明書
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Technical Support

Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Taurohyodeoxycholic acid (sodium) 構造式

CAS 番号 : 38411-85-7

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 77	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 77	在庫あり	Estimated Time of Arrival: December 31
Solid
50 mg	$70	在庫あり	Estimated Time of Arrival: December 31
100 mg	$110	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of Taurohyodeoxycholic acid sodium:

Taurohyodeoxycholic acid 在庫あり
Taurohyodeoxycholic acid-d₄ sodium お問い合わせ

顧客検証

Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

TNF Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target^[4]

IL-6

TNFR1

体内実験

Taurohyodeoxycholic acid reduces the size and weight of human gallstones in vitro. Taurohyodeoxycholic acid increases bile flow, bile cholesterol secretion and bile lipid secretion in rats. Co-administration of Taurohyodeoxycholic acid and Taurochenodeoxycholic acid prevented Taurohyodeoxycholic acid-induced hepatotoxicity and increased bile flow and bile acid and phospholipid secretion in rats.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

521.69

分子式

C₂₆H₄₄NNaO₆S

CAS 番号

38411-85-7

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@]3([H])[C@](C[C@@H]([C@]1([H])C[C@@H](CC2)O)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCC(NCCS(=O)(O[Na])=O)=O)C

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

H₂O : 62.5 mg/mL (119.80 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9168 mL	9.5842 mL	19.1685 mL
5 mM	0.3834 mL	1.9168 mL	3.8337 mL
10 mM	0.1917 mL	0.9584 mL	1.9168 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.99%

Select Batch:

データシート (273 KB) SDS (394 KB)

COA (248 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Roda A, et al. Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the rat. Hepatology. 1998 Feb;27(2):520-5. [Content Brief]

[2]. Angelico M, et al. Dissolution of human cholesterol gallstones in bile salt/lecithin mixtures: effect of bile salt hydrophobicity and various pHs. Scand J Gastroenterol. 1995 Dec;30(12):1178-85. [Content Brief]

[3]. Angelico M, et al. Effect of taurohyodeoxycholic acid, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat. Dig Dis Sci. 1994 Nov;39(11):2389-97. [Content Brief]

[4]. Solmon Kusuma S, et al. Antineoplastic activity of monocrotaline against hepatocellular carcinoma[J]. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 2014, 14(9): 1237-1248.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.9168 mL	9.5842 mL	19.1685 mL	47.9212 mL
	5 mM	0.3834 mL	1.9168 mL	3.8337 mL	9.5842 mL
	10 mM	0.1917 mL	0.9584 mL	1.9168 mL	4.7921 mL
	15 mM	0.1278 mL	0.6389 mL	1.2779 mL	3.1947 mL
	20 mM	0.0958 mL	0.4792 mL	0.9584 mL	2.3961 mL
	25 mM	0.0767 mL	0.3834 mL	0.7667 mL	1.9168 mL
	30 mM	0.0639 mL	0.3195 mL	0.6389 mL	1.5974 mL
	40 mM	0.0479 mL	0.2396 mL	0.4792 mL	1.1980 mL
	50 mM	0.0383 mL	0.1917 mL	0.3834 mL	0.9584 mL
	60 mM	0.0319 mL	0.1597 mL	0.3195 mL	0.7987 mL
	80 mM	0.0240 mL	0.1198 mL	0.2396 mL	0.5990 mL
	100 mM	0.0192 mL	0.0958 mL	0.1917 mL	0.4792 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.