Taurocholic acid sodium
Based on 34 publication(s) in Google Scholar
Taurocholic acid sodium (Sodium taurocholate) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium has immunoregulation effect.
For research use only. We do not sell to patients.
- Purity: 99.82%
- CAS No.: 145-42-6
- Formula: C26H44NNaO7S
- Molecular Weight:537.68
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications Citing Use of MedChemExpress (MCE) Taurocholic acid sodium
More- Nature. 2026 Mar;651(8104):251-259. [Abstract]
- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Science. 2024 Mar 22;383(6689):eadj4591. [Abstract]
- Nat Commun. 2025 Aug 30;16(1):8124. [Abstract]
- Microbiome. 2025 Jun 18;13(1):145. [Abstract]
- Adv Sci (Weinh). 2025 Mar;12(12):e2411719. [Abstract]
- Plant Commun. 2025 Jan 13;6(1):101181. [Abstract]
- Research (Wash D C). 2022 Nov 2:2022:9784081. [Abstract]
- Cancer Lett. 2026 Aug 28:654:218589. [Abstract]
- Adv Healthc Mater. 2025 Apr;14(9):e2402773. [Abstract]
- Cell Death Discov. 2025 Jul 23;11(1):338. [Abstract]
- J Transl Med. 2024 Dec 20;22(1):1124. [Abstract]
- Proc Natl Acad Sci U S A. 2025 Dec 2;122(48):e2524436122. [Abstract]
- Aging Cell. 2026 Jan;25(1):e70295. [Abstract]
- Food Funct. 2024 Sep 30;15(19):9916-9927. [Abstract]
- Food Funct. 2024 May 7;15(9):5088-5102. [Abstract]
- RSC Adv. 2018 Feb 23;8(16):8469-8483. [Abstract]
- Int J Mol Sci. 2025 Feb 22;26(5):1899. [Abstract]
- Int Immunopharmacol. 2025 Jan 3:145:113739. [Abstract]
- Biomolecules. 2022 Jul 31;12(8):1063. [Abstract]
- J Enzyme Inhib Med Chem. 2025 Dec;40(1):2501743. [Abstract]
- Sci Rep. 2024 Oct 31;14(1):26216. [Abstract]
- Mol Cell Biochem. 2026 Jun 29. [Abstract]
- Poult Sci. 2025 Jun 25;104(9):105489. [Abstract]
- Biomedicines. 2025 Apr 4;13(4):874. [Abstract]
- FASEB J. 2022 May;36(5):e22305. [Abstract]
- Antiviral Res. 2019 Sep:169:104544. [Abstract]
- Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Oct 3;1871(1):159692. [Abstract]
- J Pharm Biomed Anal. 2025 Jul 15:259:116760. [Abstract]
- Placenta. 2024 Mar 25:148:20-30. [Abstract]
- Mol Reprod Dev. 2026 Apr;93(4):e70105. [Abstract]
- Research Square Preprint. 2024 Feb 13.
- Research Square Print. 2022 Aug.
- SSRN. 2022 Jan 26.
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WB
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RT-PCR
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In Vivo Efficacy Study
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ELISA
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Histological Imaging/Staining
All VEGFR Isoforms
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
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Microbial Metabolite |
Human Endogenous Metabolite |
Taurocholic acid (100 μM, 24 h) sodium decreases the proportion of CD3+CD8+ T and NK cells in isolated PBMCs from HBeAg-positive CHB patients[2].
Taurocholic acid (100 μM, 24 h) sodium decreases IFN-α stimulated cytokine and cytotoxic granule levels (IFN-γ, TNF-α, granzyme B) in CD3+CD8+ T and NK cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Taurocholic acid (1% in diet, 1 week) sodium prevents hepatic artery ligation (HAL)-induced cholangiocyte damage in rats by upregulation of VEGF-A expression[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice[2]
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Dosage:100 mg/kg
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Administration:oral gavage, for 2 weeks after tail vein injection with rAAV8-1.3HBV for 6 weeks
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Result:Reduced the percentage of NK and CD3+CD8+ T cells.
Increases serum HBsAg, HBeAg, and HBV DNA levels.
Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
Taurocholic acid can be used in animal modeling to create stress-induced gastric injury models and pancreatitis models[3][4][5].
Administration: 30-300 mg/kg • p.o • single dose.
The pylorus-ligated rats are then placed in cages with restricted movement.
Subsequently, the cages are immersed in a water bath maintained at 23°C until the water level reaches the xiphoid process of the rats, lasting for 7 hours.
Seven hours later, the animals are sacrificed under ether anesthesia, and the stomach of each animal is removed. The gastric contents are collected through the esophagus and analyzed for volume and acidity.
Administration: 1 mL/kg• retrograde infusion into the common pancreaticobiliary duct• at a speed of 0.25 mL/min[4]
Mice: Balb/c and Wistar• male • weighing 25-30 g and 250-300 g[5]
Administration: 1 mL/kg• retrograde infusion• perfusion for 8 h[5]
(2) Pancreatic acinar cells were isolated freshly from Balb/c or C57/BL6J mice using a collagenase IV. Cells were treated under room temperature, and used within 4 hours after isolation[2].
Biochemical Analysis: Taurocholic acid administration increased serum amylase and lipase activities[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 145-42-6
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Appearance Solid
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Molecular Weight 537.68
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Formula C26H44NNaO7S
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Color White to off-white
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SMILES
C[C@H](CCC(NCCS(=O)(O[Na])=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C
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Synonyms
Sodium taurocholate; N-Choloyltaurine sodium
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (34)
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Journal Impact Factor
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Most Recent
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Nature
2026 Mar;651(8104):251-259. PMID: 41606314 -
Nature
2025 Jul;643(8070):192-200. PMID: 39695227
Taurocholic acid sodium purchased from MedChemExpress. Usage Cited in: Nature. 2025 Jul;643(8070):192-200. [Abstract]
Taurocholic acid (TCA, 100 μM, 4 h) activated AMPK depending on the cAMP–Epac–MEK pathway in primary hepatocytes.
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Science
Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export. [Abstract]2024 Mar 22;383(6689):eadj4591. PMID: 38513023 -
Nat Commun
2025 Aug 30;16(1):8124. PMID: 40885756 -
Microbiome
Maternal intestinal L. vaginalis facilitates embryo implantation and survival through enhancing uterine receptivity in sows. [Abstract]2025 Jun 18;13(1):145. PMID: 40533850 -
Adv Sci (Weinh)
Targeting FDFT1 Reduces Cholesterol and Bile Acid Production and Delays Hepatocellular Carcinoma Progression Through the HNF4A/ALDOB/AKT1 Axis. [Abstract]2025 Mar;12(12):e2411719. PMID: 39899681
Taurocholic acid sodium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Mar;12(12):e2411719. [Abstract]
The mRNA levels of ALDOB in Huh7 or HCCLM3 cells treated with various bile acids (100 μM, 24 h). All data are presented as mean ± SD. Data were analyzed by one-way ANOVA with Bonferroni multiple-comparison correction. CA, cholic acid; TCA, taurocholic acid; GCA, glycocholic acid; TCDCA, taurochenodeoxycholic acid; GCDCA, glycochenodeoxycholic acid; LCA, lithocholic acid; TLCA, taurolithocholic acid; GLCA, glycolithocholic acid; DCA, deoxycholic acid; TDCA, taurodeoxycholic acid; GDCA, glycodeoxycholic acid; UDCA, ursodeoxycholic acid; TUDCA, tauroursodeoxycholic acid; GUDCA, glycoursodeoxycholic acid.
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Plant Commun
Structural insights into brassinosteroid export mediated by the Arabidopsis ABC transporter ABCB1. [Abstract]2025 Jan 13;6(1):101181. PMID: 39497419 -
Research (Wash D C)
Activation of Pancreatic Acinar FXR Protects against Pancreatitis via Osgin1-Mediated Restoration of Efficient Autophagy. [Abstract]2022 Nov 2:2022:9784081. PMID: 36405253 -
Cancer Lett
Bile acid retention impairs tumoral antigen presentation and intrinsic tumor suppression in MASH-HCC. [Abstract]2026 Aug 28:654:218589. PMID: 42173274 -
Adv Healthc Mater
Sodium Butyrate-Loaded Microspheres With Enhanced Bioavailability for Targeted Treatment of Intestinal Barrier Injury. [Abstract]2025 Apr;14(9):e2402773. PMID: 39629540 -
Cell Death Discov
RBM17 promotes hepatocellular carcinoma progression by regulating lipid metabolism and immune microenvironment: implications for therapeutic targeting. [Abstract]2025 Jul 23;11(1):338. PMID: 40702000 -
J Transl Med
Conjugated bile acids alleviate acute pancreatitis through inhibition of TGR5 and NLRP3 mediated inflammation. [Abstract]2024 Dec 20;22(1):1124. PMID: 39707318 -
Proc Natl Acad Sci U S A
Antibiotics accumulate in Klebsiella pneumoniae liver abscesses but fail to eliminate antibiotic-tolerant populations. [Abstract]2025 Dec 2;122(48):e2524436122. PMID: 41296732 -
Aging Cell
Human Umbilical Cord Plasma Metabolomics Uncover Potential Metabolites for Combating Aging. [Abstract]2026 Jan;25(1):e70295. PMID: 41299210 -
Food Funct
Arachidonic acid enhances hepatocyte bile acid uptake and alleviates cholestatic liver disease by upregulating OATP1 expression. [Abstract]2024 Sep 30;15(19):9916-9927. PMID: 39258405 -
Food Funct
Taurocholic acid ameliorates hypertension through the activation of TGR5 in the hypothalamic paraventricular nucleus. [Abstract]2024 May 7;15(9):5088-5102. PMID: 38666497
Taurocholic acid sodium purchased from MedChemExpress. Usage Cited in: Food Funct. 2024 May 7;15(9):5088-5102. [Abstract]
Taurocholic acid (TCA, infused into the PVN at 10 μg per day for 28 days) reduced systolic blood pressure in spontaneously hypertensive rats.
Taurocholic acid sodium purchased from MedChemExpress. Usage Cited in: Food Funct. 2024 May 7;15(9):5088-5102. [Abstract]
Taurocholic acid (TCA, infused into the PVN at 10 μg per day for 28 days) reduced plasma levels of norepinephrine in spontaneously hypertensive rats.
Taurocholic acid sodium purchased from MedChemExpress. Usage Cited in: Food Funct. 2024 May 7;15(9):5088-5102. [Abstract]
Taurocholic acid (TCA, infused into the PVN at 10 μg per day for 28 days) reduced cardiomyocyte dilation (A-B) and fibrosis (C-D) in spontaneously hypertensive rats.
Taurocholic acid sodium purchased from MedChemExpress. Usage Cited in: Food Funct. 2024 May 7;15(9):5088-5102. [Abstract]
Taurocholic acid (TCA, infused into the PVN at 10 μg per day for 28 days) reduced the average fluorescence intensity of DHE in cardiomyocytes of spontaneously hypertensive rats.
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RSC Adv
Cytosolic β-glucosidase inhibition and renal blood flow suppression are leading causes for the enhanced systemic exposure of salidroside in hypoxic rats. [Abstract]2018 Feb 23;8(16):8469-8483. PMID: 35539855 -
Int J Mol Sci
MGST1 Protects Pancreatic Ductal Cells from Inflammatory Damage in Acute Pancreatitis by Inhibiting Ferroptosis: Bioinformatics Analysis with Experimental Validation. [Abstract]2025 Feb 22;26(5):1899. PMID: 40076525 -
Int Immunopharmacol
Detection of serum lactate dehydrogenase A and its metabolites on placental function in patients with intrahepatic cholestasis of pregnancy. [Abstract]2025 Jan 3:145:113739. PMID: 39662271 -
Biomolecules
The Rabep1-Mediated Endocytosis and Activation of Trypsinogen to Promote Pancreatic Stellate Cell Activation. [Abstract]2022 Jul 31;12(8):1063. PMID: 36008957 -
J Enzyme Inhib Med Chem
Natural product sennoside B disrupts liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein by inhibiting its RNA-binding activity. [Abstract]2025 Dec;40(1):2501743. PMID: 40371698 -
Sci Rep
Resveratrol improved mitochondrial biogenesis by activating SIRT1/PGC-1α signal pathway in SAP. [Abstract]2024 Oct 31;14(1):26216. PMID: 39482340 -
Mol Cell Biochem
Bile acid-induced TBG depletion promotes trophoblast apoptosis via local thyroxine insufficiency in intrahepatic cholestasis of pregnancy. [Abstract]2026 Jun 29. PMID: 42371391 -
Poult Sci
Molecular mechanisms of photoperiod regulation of bile acid metabolism in Taihe silky fowls based on the gut-liver axis. [Abstract]2025 Jun 25;104(9):105489. PMID: 40592289 -
Biomedicines
2025 Apr 4;13(4):874. PMID: 40299495 -
FASEB J
The metabolomic profiling identifies N, N-dimethylglycine as a facilitator of dorsal root ganglia neuron axon regeneration after injury. [Abstract]2022 May;36(5):e22305. PMID: 35394692 -
Antiviral Res
A HTRF based competitive binding assay for screening specific inhibitors of HIV-1 capsid assembly targeting the C-Terminal domain of capsid. [Abstract]2019 Sep:169:104544. PMID: 31254557 -
Biochim Biophys Acta Mol Cell Biol Lipids
Integrated proteomic and metabolomic analysis reveals lipid metabolic dysregulation and ferroptosis as potential drivers of placental dysfunction in intrahepatic cholestasis of pregnancy. [Abstract]2025 Oct 3;1871(1):159692. PMID: 41047095 -
J Pharm Biomed Anal
Integrating 16S rDNA sequencing analysis and targeted metabolomics to explore the mechanism of Xiexin Tang in treating atherosclerosis mice induced by high-fat diet. [Abstract]2025 Jul 15:259:116760. PMID: 40014894 -
Placenta
The role of ERp29/FOS/EMT pathway in excessive apoptosis of placental trophoblast cells in intrahepatic cholestasis of pregnancy. [Abstract]2024 Mar 25:148:20-30. PMID: 38346375 -
Mol Reprod Dev
PIP2 Accumulation in the Spongiotrophoblast Drives Trophoblast Apoptosis in Intrahepatic Cholestasis of Pregnancy. [Abstract]2026 Apr;93(4):e70105. PMID: 42017405 -
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Solvent & Solubility
DMSO : ≥ 100 mg/mL (185.98 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (185.98 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.65 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.65 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (287 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Caiyun Wang, et al. Effects of taurocholic acid on immunoregulation in mice. Int Immunopharmacol. 2013 Feb;15(2):217-22. [Content Brief]
[2]. Xun Z,et al. Taurocholic acid inhibits the response to interferon-α therapy in patients with HBeAg-positive chronic hepatitis B by impairing CD8+ T and NK cell function. Cell Mol Immunol. 2021 Feb;18(2):461-471. [Content Brief]
[3]. Glaser S, et al. Taurocholic acid prevents biliary damage induced by hepatic artery ligation in cholestatic rats. Dig Liver Dis. 2010 Oct;42(10):709-17. [Content Brief]
[4]. Mo J, Yang A, et al. Neuronostatin ameliorates sodium taurocholate-induced acute pancreatitis in rats. Dig Dis Sci. 2013 Oct;58(10):2903-7. [Content Brief]
[5]. Du D, Yao L, et al. Protective effects of flavonoids from Coreopsis tinctoria Nutt. on experimental acute pancreatitis via Nrf-2/ARE-mediated antioxidant pathways. J Ethnopharmacol. 2018 Oct 5;224:261-272. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.8598 mL | 9.2992 mL | 18.5984 mL | 46.4961 mL |
| 5 mM | 0.3720 mL | 1.8598 mL | 3.7197 mL | 9.2992 mL | |
| 10 mM | 0.1860 mL | 0.9299 mL | 1.8598 mL | 4.6496 mL | |
| 15 mM | 0.1240 mL | 0.6199 mL | 1.2399 mL | 3.0997 mL | |
| 20 mM | 0.0930 mL | 0.4650 mL | 0.9299 mL | 2.3248 mL | |
| 25 mM | 0.0744 mL | 0.3720 mL | 0.7439 mL | 1.8598 mL | |
| 30 mM | 0.0620 mL | 0.3100 mL | 0.6199 mL | 1.5499 mL | |
| 40 mM | 0.0465 mL | 0.2325 mL | 0.4650 mL | 1.1624 mL | |
| 50 mM | 0.0372 mL | 0.1860 mL | 0.3720 mL | 0.9299 mL | |
| 60 mM | 0.0310 mL | 0.1550 mL | 0.3100 mL | 0.7749 mL | |
| 80 mM | 0.0232 mL | 0.1162 mL | 0.2325 mL | 0.5812 mL | |
| 100 mM | 0.0186 mL | 0.0930 mL | 0.1860 mL | 0.4650 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.