1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. VEGFR Inhibitors

VEGFR Inhibitors

VEGFR1/Flt-1

VEGFR2/KDR/Flk-1

VEGFR3/Flt-4

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

VEGFR Inhibitors & Antagonists
Product Name VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4 Purity
Sorafenib  
VEGFR2, IC50: 90 nM
VEGFR3, IC50: 20 nM
99.92%
Lenvatinib
VEGFR1, IC50: 22 nM
VEGFR2, IC50: 4 nM
VEGFR3, IC50: 5.2 nM
99.84%
Sunitinib  
VEGFR2, IC50: 80 nM
  98.96%
Regorafenib
VEGFR1, IC50: 13 nM
VEGFR2, IC50: 4.2 nM
VEGFR3, IC50: 46 nM
99.65%
Nintedanib
VEGFR1, IC50: 34 nM
VEGFR2, IC50: 13 nM
VEGFR3, IC50: 13 nM
99.82%
Ponatinib hydrochloride  
VEGFR2, IC50: 1.5 nM
  99.26%
Cabozantinib
Flt-1, IC50: 12 nM
VEGFR2, IC50: 0.035 nM
Flt-4, IC50: 6 nM
99.96%
Semaxinib  
Flk-1, IC50: 1.23 μM
  99.96%
Ponatinib  
VEGFR2, IC50: 1.5 nM
  99.43%
Axitinib
VEGFR1, IC50: 0.1 nM
VEGFR2, IC50: 0.2 nM
VEGFR3, IC50: 0.1 nM
99.94%
Pazopanib
VEGFR1, IC50: 10 nM
VEGFR2, IC50: 30 nM
VEGFR3, IC50: 47 nM
99.77%
Sorafenib Tosylate  
VEGFR2, IC50: 90 nM
VEGFR3, IC50: 20 nM
99.75%
PD173074  
VEGFR2, IC50: 100 nM
  99.70%
Vandetanib  
VEGFR2, IC50: 40 nM
VEGFR3, IC50: 110 nM
99.95%
SU 5402  
VEGFR2, IC50: 20 nM
  99.38%
Linifanib
Flt-1, IC50: 3 nM
KDR, IC50: 4 nM
  99.72%
5Z-7-Oxozeaenol  
VEGFR-2, IC50: 52 nM
VEGFR-3, IC50: 110 nM
99.50%
Foretinib  
KDR, IC50: 0.9 nM
  99.77%
Sunitinib Malate  
VEGFR2, IC50: 80 nM
  99.91%
Nintedanib esylate
VEGFR1, IC50: 34 nM
VEGFR2, IC50: 13 nM
VEGFR3, IC50: 13 nM
99.94%
Dovitinib
VEGFR1, IC50: 10 nM
VEGFR2, IC50: 13 nM
VEGFR3, IC50: 8 nM
99.94%
PF-03814735
Flt-1, IC50: 10 nM
    99.82%
Sitravatinib
VEGFR1, IC50: 6 nM
VEGFR2, IC50: 5 nM
VEGFR3, IC50: 2 nM
99.59%
Cediranib
Flt-1, IC50: 5 nM
KDR, IC50: 1 nM
Flt-4, IC50: 3 nM
99.58%
Gandotinib  
KDR, IC50: 109 nM
Flt-4, IC50: 25 nM
99.82%
Lenvatinib mesylate
VEGFR1, IC50: 22 nM
VEGFR2, IC50: 4 nM
VEGFR3, IC50: 5.2 nM
99.86%
GW806742X  
VEGFR2, IC50: 2 nM
  99.91%
Tivozanib
VEGFR1, IC50: 0.21 nM
VEGFR2, IC50: 0.16 nM
VEGFR3, IC50: 0.24 nM
99.37%
Fruquintinib
VEGFR1, IC50: 33 nM
VEGFR2, IC50: 35 nM
VEGFR3, IC50: 0.5 nM
99.94%
MAZ51    
VEGFR3
98.21%
Cabozantinib S-malate  
VEGFR2, IC50: 0.035 nM
  99.84%
Pazopanib Hydrochloride
VEGFR1, IC50: 10 nM
VEGFR2, IC50: 30 nM
VEGFR3, IC50: 47 nM
99.88%
RAF265  
VEGFR2
  99.90%
Vatalanib dihydrochloride  
VEGFR2, IC50: 37 nM
  99.91%
SAR131675    
VEGFR3, IC50: 23 nM
99.48%
Ramucirumab  
VEGFR-2
  99.40%
Sulfatinib
VEGFR1
VEGFR2
VEGFR3
98.01%
ENMD-2076  
KDR, IC50: 58.2 nM
Flt-4, IC50: 15.9 nM
99.12%
GW806742X hydrochloride  
VEGFR2, IC50: 2 nM
  98.77%
Ki8751  
VEGFR2, IC50: 0.9 nM
  99.17%
Telatinib  
VEGFR2, IC50: 6 nM
VEGFR3, IC50: 4 nM
99.60%
(Z)-Guggulsterone  
VEGF-R2
  98.43%
Golvatinib  
VEGFR2, IC50: 16 nM
  99.76%
CP-547632 hydrochloride  
VEGFR-2, IC50: 11 nM
  99.88%
PP121  
VEGFR2, IC50: 12 nM
  99.08%
CP-547632  
VEGFR-2, IC50: 11 nM
  ≥99.0%
Motesanib
VEGFR1, IC50: 2 nM
VEGFR2, IC50: 3 nM
VEGFR3, IC50: 6 nM
99.99%
Tesevatinib  
KDR, IC50: 1.5 nM
Flt-4, IC50: 8.7 nM
99.21%
Regorafenib Hydrochloride
VEGFR1, IC50: 13 nM
VEGFR2, IC50: 4.2 nM
VEGFR3, IC50: 46 nM
99.58%
SU14813
VEGFR1, IC50: 2 nM
VEGFR2, IC50: 50 nM
  99.63%
Orantinib
Flt-1, Ki: 2.1 μM
    99.13%
TAK-593
VEGFR1, IC50: 3.2 nM
VEGFR2, IC50: 0.95 nM
VEGFR3, IC50: 1.1 nM
99.62%
ODM-203
VEGFR1, IC50: 26 nM
VEGFR2, IC50: 9 nM
VEGFR3, IC50: 5 nM
99.33%
Brivanib  
VEGFR2, IC50: 25 nM
  99.24%
SU5408  
VEGFR2, IC50: 70 nM
  ≥98.0%
Regorafenib monohydrate
VEGFR1, IC50: 13 nM
VEGFR2, IC50: 4.2 nM
VEGFR3, IC50: 46 nM
99.96%
Dovitinib lactate
VEGFR1, IC50: 1 nM
VEGFR2, IC50: 13 nM
VEGFR3, IC50: 8 nM
99.62%
Lucitanib
VEGFR1, IC50: 7 nM
VEGFR2, IC50: 25 nM
VEGFR3, IC50: 10 nM
98.94%
Cediranib maleate
Flt-1, IC50: 5 nM
KDR, IC50: 1 nM
Flt-4, IC50: 3 nM
99.84%
Chiauranib
Flt-1, IC50: 8 nM
KDR, IC50: 7 nM
Flt-4, IC50: 9 nM
99.28%
KRN-633
VEGFR1, IC50: 170 nM
VEGFR2, IC50: 160 nM
VEGFR3, IC50: 125 nM
98.27%
SU1498  
Flk-1, IC50: 700 nM
  98.37%
Altiratinib  
VEGFR2, IC50: 9.2 nM
  98.06%
ZM323881 hydrochloride  
VEGFR2, IC50: 2 nM
  99.33%
Brivanib (alaninate)  
VEGFR2, IC50: 25 nM
  99.45%
Ningetinib  
VEGFR2, IC50: 1.9 nM
  99.79%
K00546  
VEGF-R2, IC50: 32 nM
  98.78%
Ilorasertib hydrochloride
VEGFR1, IC50: 1 nM
VEGFR2, IC50: 2 nM
VEGFR3, IC50: 43 nM
99.67%
ZM 306416
Flt-1, IC50: 2 μM
KDR, IC50: 100 nM
  99.80%
WHI-P180  
KDR, IC50: 66 nM
  99.62%
TG 100801
VEGFR1, IC50: 2 nM
VEGFR2, IC50: 7 nM
  98.60%
PF 477736  
VEGFR2, Ki: 8 nM
  99.21%
AZD2932  
VEGFR2, IC50: 8 nM
  ≥98.0%
Toceranib phosphate  
Flk-1, Ki: 6 nM
  98.02%
XL092  
VEGFR2, IC50: 1.6 nM
  99.52%
Ningetinib Tosylate  
VEGFR2, IC50: 1.9 nM
  99.92%
SCR-1481B1
VEGFR1
    99.82%
Tyrosine kinase-IN-1
Flt-1, IC50: 4 nM
KDR, IC50: 20 nM
  99.34%
MGCD-265 analog  
VEGFR2, IC50: 10 nM
  98.57%
JI-101  
VEGFR2
  99.43%
Toceranib  
Flk-1, Ki: 6 nM
 
Telatinib mesylate  
VEGFR2, IC50: 6 nM
VEGFR3, IC50: 4 nM
99.46%
(Z)-Orantinib  
Flk-1/KDR, IC50: 2.1 μM
  99.02%
Chloropyramine hydrochloride    
VEGFR-3
99.73%
SU4312  
Flk-1
  98.19%
ENMD-2076 Tartrate  
KDR, IC50: 58.2 nM
Flt-4, IC50: 15.9 nM
98.87%
Motesanib Diphosphate
VEGFR1, IC50: 2 nM
VEGFR2, IC50: 3 nM
VEGFR3, IC50: 6 nM
99.85%
Famitinib  
VEGFR-2, IC50: 4.2 nM
  98.09%
OSI-930
Flt-1, IC50: 8 nM
KDR, IC50: 9 nM
  98.13%
Acrizanib  
VEGFR-2, IC50: 17.4 nM
  99.84%
Hypothemycin
VEGFR1, Ki: 70 nM
VEGFR2, Ki: 10 nM
  ≥98.0%
BMS-794833  
VEGFR2, IC50: 15 nM
  99.78%
EOC317  
VEGFR2, IC50: 2 nM
  98.11%
BFH772  
VEGFR2, IC50: 3 nM
 
Tyrphostin AG1433  
Flk-1, IC50: 9.3 μM
  99.20%
NVP-BAW2881
VEGFR1, IC50: 820 nM
VEGFR2, IC50: 9 nM
VEGFR3, IC50: 420 nM
98.17%
R1530  
KDR, IC50: 10 nM
  99.06%
SU14813 maleate
VEGFR1, IC50: 2 nM
VEGFR2, IC50: 50 nM
  99.04%
GSK2646264  
VEGFR2, pIC50: 4.5
  98.39%
VEGFR-3-IN-1    
VEGFR3, IC50: 110.4 nM
Tivozanib hydrochloride hydrate
VEGFR-1, IC50: 0.21 nM
VEGFR-2, IC50: 0.16 nM
VEGFR-3, IC50: 0.24 nM
99.88%
SU5205  
Flk-1, IC50: 9.6 μM
  98.44%
SU5214  
Flk-1, IC50: 14.8 μM
  98.29%
NVP-ACC789
VEGFR-1, IC50: 0.38 μM
VEGFR-2, IC50: 0.02 μM
mVEGFR-2, IC50: 0.23 μM
VEGFR-3, IC50: 0.18 μM
99.94%
VEGFR-2-IN-5  
VEGFR2
 
CP-547632 TFA  
VEGFR2, IC50: 11 nM
  99.42%
Sunitinib-d10  
VEGFR2, IC50: 80 nM
  99.89%
Ponatinib-d8  
VEGFR2, IC50: 1.5 nM
  98.44%
Vandetanib hydrochloride  
VEGFR2, IC50: 40 nM
VEGFR3, IC50: 110 nM
TG 100572
VEGFR1, IC50: 2 nM
VEGFR2, IC50: 7 nM
 
ZD-4190  
VEGFR2
  99.20%
Ilorasertib
VEGFR1, IC50: 1 nM
VEGFR2, IC50: 2 nM
VEGFR3, IC50: 43 nM
≥98.0%
Sitravatinib malate
VEGFR1, IC50: 6 nM
VEGFR2, IC50: 5 nM
VEGFR3, IC50: 2 nM
Dovitinib lactate hydrate
VEGFR1, IC50: 1 nM
VEGFR2, IC50: 13 nM
VEGFR3, IC50: 8 nM
Cabozantinib hydrochloride
Flt-1, IC50: 12 nM
VEGFR2, IC50: 0.035 ± 0. nM
Flt-4, IC50: 6 nM
Regorafenib mesylate
VEGFR1, IC50: 13 ± 0.4 nM
VEGFR2, IC50: 4.2 ± 1.6 nM
VEGFR3, IC50: 46 ± 10 nM
Famitinib malate  
VEGFR2, IC50: 4.2 nM
 
R916562  
VEGF-R2, IC50: 24 nM
 
VEGFR-2-IN-21  
VEGFR-2, IC50: 0.10 μM
 
VEGFR-2-IN-15  
VEGFR2
 
SU5204  
VEGFR2, IC50: 4 μM
  98.89%
VEGFR-2/BRAF-IN-2  
VEGFR2, IC50: 0.111 μM
 
VEGFR-2-IN-18  
VEGFR2, IC50: 60 nM
 
FGFR3-IN-2  
VEGFR2, IC50: 570 nM
 
Vatalanib free base  
VEGFR2, IC50: 37 nM
 
(Rac)-SAR131675    
VEGFR3
VEGFR-2-IN-17  
VEGFR2, IC50: 67.25 nM
 
VEGFR-2/BRAF-IN-1  
VEGFR2, IC50: 0.049 μM
 
VEGFR-2-IN-23  
VEGFR-2, IC50: 0.19 nM
 
HDAC-IN-35  
VEGFR2, IC50: 13.2 μM
 
VEGFR-2-IN-19  
VEGFR2
 
hVEGF-IN-2
VEGFR1, IC50: 2.5 μM
   
VEGFR-2-IN-27  
VEGFR-2, IC50: 14.8 nM
 
YF-452  
VEGFR2
 
VEGFR-2-IN-13  
VEGFR2, IC50: 3.4 nM
 
VEGFR-2/DHFR-IN-1  
VEGFR-2, IC50: 0.384 μM
 
VEGFR-2-IN-28  
VEGFR-2, IC50: 0.83 μM
 
ML786 dihydrochloride  
KDR, IC50: 6.2 nM
 
VEGFR-2-IN-29  
VEGFR-2, IC50: 16.5 nM
  99.71%
VEGFR-2/DHFR-IN-2  
VEGFR2, IC50: 0.623 μM
 
Takeda-6D  
VEGFR2, IC50: 2.2 nM
 
HSP90-IN-13  
VEGFR-2, IC50: 126.95 nM
 
AAL993
VEGFR1, IC50: 130 nM
VEGFR2, IC50: 23 nM
VEGFR3, IC50: 18 nM
VEGFR2-IN-1  
VEGFR2, IC50: 19.8 nM
 
3-Methylthienyl-carbonyl-JNJ-7706621  
VEGFR2, IC50: 0.13 μM
 
c-Met-IN-11  
VEGFR-2, IC50: 71.1 nM
 
VEGFR2-IN-2  
VEGFR2, IC50: 19.32 nM
 
VEGFR-2-IN-22  
VEGFR2, IC50: 19.82 nM
 
EGFR-IN-57  
VEGFR-2, IC50: 0.087 μM
 
GW768505A free base  
KDR ([1])
 
MET kinase-IN-3  
VEGFR2, IC50: 68 nM
 
VEGFR-2-IN-16  
VEGFR2, IC50: 86.36 nM
 
TIE-2/VEGFR-2 kinase-IN-2  
VEGFR-2
 
Multi-kinase-IN-2
VEGFR-1, IC50: 31 ± 2.1 nM
VEGFR-2, IC50: 6.5 ± 0.9 nM
VEGFR-3, IC50: 6.3 ± 0.5 nM
SU5208  
VEGFR2
 
Isolinderalactone  
VEGFR2
 
Multi-kinase-IN-3  
VEGFR-2, IC50: 58.3 ± 5.9 nM
 
VS 8  
VEGFR-2
 
VEGFR-2-IN-14  
VEGFR2
 
JNJ-38158471  
VEGFR-2, IC50: 40 nM
 
JK-P3  
VEGFR2, IC50: 7.83 μM
 
VEGFR-2-IN-26  
VEGFR-2, IC50: 15.5 nM
 
VEGFR-IN-1
Flt-1, IC50: 0.18 μM
KDR, IC50: 0.02 μM
 
VEGFR-2-IN-11  
VEGFR-2, IC50: 60.27 nM
 
VEGFR-2-IN-25  
VEGFR2, IC50: 12.1 nM
 
DMH4  
VEGFR2, IC50: 0.16 μM
 
PI3K/VEGFR2-IN-1  
VEGFR2, IC50: 68 μM
 
Henatinib  
VEGFR-2, IC50: 0.6 nM
 
VEGFR-2-IN-24  
VEGFR2, IC50: 0.22 μM
 
WHI-P180 hydrochloride  
KDR, IC50: 66 nM
 
ZM323881  
VEGFR2, IC50: 2 nM
 
TG 100801 Hydrochloride
VEGFR1, IC50: 2 nM
VEGFR2, IC50: 7 nM
 
ZK-261991  
VEGFR2, IC50: 5 nM
 
Pamufetinib  
VEGFR2, IC50: 30 nM
 
Vandetanib trifluoroacetate  
VEGFR2, IC50: 40 nM
VEGFR3, IC50: 110 nM
VEGFR-2-IN-12  
VEGFR2, IC50: 0.037 μM
 
VEGFR-2-IN-9  
KDR, IC50: 7 nM