Taurocholic acid-d8 sodium
Based on 1 Customer Validation
Taurocholic acid-d8 (sodium) is deuterium labeled Taurocholic acid (sodium). Taurocholic acid sodium (Sodium taurocholate) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium has immunoregulation effect.
For research use only. We do not sell to patients.
- Purity: 98.80%
- CAS No.: 1351996-69-4
- Formula: C26H36D8NNaO7S
- Molecular Weight:545.73
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1351996-69-4
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Unlabeled Cas 145-42-6
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Appearance Solid
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Molecular Weight 545.73
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Formula C26H36D8NNaO7S
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Color White to off-white
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SMILES
O=C(CC[C@H]([C@@]1([C@]2([C@H](C[C@]3([C@@]([H])([C@@H](C[C@@]4(C([2H])([C@@H](C([2H])(C[C@@]43C)[2H])O)[2H])[H])O)[C@@]2(CC1)[H])[H])O)C)[H])C)NC([2H])(C([2H])(S(=O)(O[Na])=O)[2H])[2H]
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Synonyms
Sodium taurocholate-d8 (Standard); N-Choloyltaurine-d8 sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 175 mg/mL (320.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (183.24 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Caiyun Wang, et al. Effects of taurocholic acid on immunoregulation in mice. Int Immunopharmacol. 2013 Feb;15(2):217-22. [Content Brief]
[3]. Xun Z,et al. Taurocholic acid inhibits the response to interferon-α therapy in patients with HBeAg-positive chronic hepatitis B by impairing CD8+ T and NK cell function. Cell Mol Immunol. 2021 Feb;18(2):461-471. [Content Brief]
[4]. Glaser S, et al. Taurocholic acid prevents biliary damage induced by hepatic artery ligation in cholestatic rats. Dig Liver Dis. 2010 Oct;42(10):709-17. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.8324 mL | 9.1620 mL | 18.3241 mL | 45.8102 mL |
| 5 mM | 0.3665 mL | 1.8324 mL | 3.6648 mL | 9.1620 mL | |
| 10 mM | 0.1832 mL | 0.9162 mL | 1.8324 mL | 4.5810 mL | |
| 15 mM | 0.1222 mL | 0.6108 mL | 1.2216 mL | 3.0540 mL | |
| 20 mM | 0.0916 mL | 0.4581 mL | 0.9162 mL | 2.2905 mL | |
| 25 mM | 0.0733 mL | 0.3665 mL | 0.7330 mL | 1.8324 mL | |
| 30 mM | 0.0611 mL | 0.3054 mL | 0.6108 mL | 1.5270 mL | |
| 40 mM | 0.0458 mL | 0.2291 mL | 0.4581 mL | 1.1453 mL | |
| 50 mM | 0.0366 mL | 0.1832 mL | 0.3665 mL | 0.9162 mL | |
| 60 mM | 0.0305 mL | 0.1527 mL | 0.3054 mL | 0.7635 mL | |
| 80 mM | 0.0229 mL | 0.1145 mL | 0.2291 mL | 0.5726 mL | |
| 100 mM | 0.0183 mL | 0.0916 mL | 0.1832 mL | 0.4581 mL |
Taurocholic acid-d8 sodium Related Classifications
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