Taurocholic acid-d5 sodium
Based on 1 Customer Validation
Taurocholic acid-d5 (sodium) is deuterium labeled Taurocholic acid (sodium). Taurocholic acid sodium (Sodium taurocholate) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium has immunoregulation effect.
For research use only. We do not sell to patients.
- Formula: C26H39D5NNaO7S
- Molecular Weight:542.72
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Storage:
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 145-42-6
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Appearance Solid
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Molecular Weight 542.72
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Formula C26H39D5NNaO7S
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SMILES
O=C(CC[C@H]([C@@]1([C@]2([C@H](C[C@]3([C@@]([H])([C@@H](C[C@@]4(C([2H])([C@@]([2H])(C([2H])(C[C@@]43C)[2H])O)[2H])[H])O)[C@@]2(CC1)[H])[H])O)C)[H])C)NCCS(=O)(O[Na])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Solvent & Solubility
DMSO : 175 mg/mL (322.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (184.26 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Xun Z,et al. Taurocholic acid inhibits the response to interferon-α therapy in patients with HBeAg-positive chronic hepatitis B by impairing CD8+ T and NK cell function. Cell Mol Immunol. 2021 Feb;18(2):461-471. [Content Brief]
[3]. Caiyun Wang, et al. Effects of taurocholic acid on immunoregulation in mice. Int Immunopharmacol. 2013 Feb;15(2):217-22. [Content Brief]
[4]. Glaser S, et al. Taurocholic acid prevents biliary damage induced by hepatic artery ligation in cholestatic rats. Dig Liver Dis. 2010 Oct;42(10):709-17. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.8426 mL | 9.2129 mL | 18.4257 mL | 46.0643 mL |
| 5 mM | 0.3685 mL | 1.8426 mL | 3.6851 mL | 9.2129 mL | |
| 10 mM | 0.1843 mL | 0.9213 mL | 1.8426 mL | 4.6064 mL | |
| 15 mM | 0.1228 mL | 0.6142 mL | 1.2284 mL | 3.0710 mL | |
| 20 mM | 0.0921 mL | 0.4606 mL | 0.9213 mL | 2.3032 mL | |
| 25 mM | 0.0737 mL | 0.3685 mL | 0.7370 mL | 1.8426 mL | |
| 30 mM | 0.0614 mL | 0.3071 mL | 0.6142 mL | 1.5355 mL | |
| 40 mM | 0.0461 mL | 0.2303 mL | 0.4606 mL | 1.1516 mL | |
| 50 mM | 0.0369 mL | 0.1843 mL | 0.3685 mL | 0.9213 mL | |
| 60 mM | 0.0307 mL | 0.1535 mL | 0.3071 mL | 0.7677 mL | |
| 80 mM | 0.0230 mL | 0.1152 mL | 0.2303 mL | 0.5758 mL | |
| 100 mM | 0.0184 mL | 0.0921 mL | 0.1843 mL | 0.4606 mL |
Taurocholic acid-d5 sodium Related Classifications
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