2. Taurocholic acid

Taurocholic acid  (Synonyms: N-Choloyltaurine)

Cat. No.: HY-B1788 Purity: ≥98.0%
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Taurocholic acid (N-Choloyltaurine) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid has immunoregulation effect.

For research use only. We do not sell to patients.

Taurocholic acid Chemical Structure

Taurocholic acid Chemical Structure

CAS No. : 81-24-3

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10 mM * 1 mL in DMSO
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Based on 10 publication(s) in Google Scholar

Other Forms of Taurocholic acid:

Taurocholic acid Related Antibodies

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  • Purity & Documentation

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Description

Taurocholic acid (N-Choloyltaurine) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid has immunoregulation effect[1].

In Vitro

Taurocholic acid (100 μM, 24 h) decreases the proportion of CD3+CD8+ T and NK cells in isolated PBMCs from HBeAg-positive CHB patients[2].
Taurocholic acid (100 μM, 24 h) decreases IFN-α stimulated cytokine and cytotoxic granule levels (IFN-γ, TNF-α, granzyme B) in CD3+CD8+ T and NK cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Taurocholic acid Related Antibodies
In Vivo

Taurocholic acid (oral gavage, 100 mg/kg, 2 weeks) promotes HBV replication by reducing the percentage of NK and CD3+CD8+ T cells in C57BL/6 mice with tail vein injection with rAAV8-1.3HBV[2].
Taurocholic acid (1% in diet, 1 week) prevents hepatic artery ligation (HAL)-induced cholangiocyte damage in rats by upregulation of VEGF-A expression[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice[2]
Dosage: 100-mg/kg
Administration: oral gavage, for 2 weeks after tail vein injection with rAAV8-1.3HBV for 6 weeks
Result: Reduced the percentage of NK and CD3+CD8+ T cells.
Increases serum HBsAg, HBeAg, and HBV DNA levels.
Molecular Weight

515.70

Formula

C26H45NO7S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H](C[C@]1([H])C[C@@H]2O)[C@@]([C@@](C[C@@H]3O)([H])[C@]1(CC2)C)([H])[C@@](CC[C@]4([H])[C@H](C)CCC(NCC[S](=O)(O)=O)=O)([H])[C@@]43C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (193.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (193.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9391 mL 9.6956 mL 19.3911 mL
5 mM 0.3878 mL 1.9391 mL 3.8782 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.85 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (4.85 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.18%

COA (249 KB) HNMR (270 KB) RP-HPLC (212 KB) MS (194 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.9391 mL 9.6956 mL 19.3911 mL 48.4778 mL
5 mM 0.3878 mL 1.9391 mL 3.8782 mL 9.6956 mL
10 mM 0.1939 mL 0.9696 mL 1.9391 mL 4.8478 mL
15 mM 0.1293 mL 0.6464 mL 1.2927 mL 3.2319 mL
20 mM 0.0970 mL 0.4848 mL 0.9696 mL 2.4239 mL
25 mM 0.0776 mL 0.3878 mL 0.7756 mL 1.9391 mL
30 mM 0.0646 mL 0.3232 mL 0.6464 mL 1.6159 mL
40 mM 0.0485 mL 0.2424 mL 0.4848 mL 1.2119 mL
50 mM 0.0388 mL 0.1939 mL 0.3878 mL 0.9696 mL
60 mM 0.0323 mL 0.1616 mL 0.3232 mL 0.8080 mL
80 mM 0.0242 mL 0.1212 mL 0.2424 mL 0.6060 mL
100 mM 0.0194 mL 0.0970 mL 0.1939 mL 0.4848 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Taurocholic acid81-24-3N-CholoyltaurineInhibitorinhibitorinhibit

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