TNFRSF4
TNFRSF4 (OX40/CD134) is an inducible T-cell costimulatory receptor that signals through TRAF2/TRAF5-mediated NF-κB activation[1]. Mechanistically, OX40 supports antigen-driven CD4+ T-cell persistence by maintaining BCL2 and BCL2L1/BCL-xL expression, while sustained survivin expression drives clonal expansion[2][3]. In disease models, the OX40L-OX40 axis promotes aberrant T follicular helper responses in systemic lupus erythematosus and marks immune escape by Tnfrsf4-expressing regulatory T cells in chronic myeloid leukemia[4][5]. Compared with membrane OX40, a soluble OX40 isoform has been identified in serum from healthy donors and patients with autoimmune disease or cancer, supporting isoform-aware assay design[6]. For experimental applications, anti-OX40 agonist antibodies such as MOXR0916 have been evaluated in advanced solid tumors to test effector T-cell costimulation and regulatory T-cell modulation[7].
References:
- [1]. Kawamata S, et al. Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation. J Biol Chem. 1998 Mar 6;273(10):5808-14. [Content Brief]
- [2]. Rogers PR, et al. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity. 2001 Sep;15(3):445-55. [Content Brief]
- [3]. Song J, et al. Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. Immunity. 2005 May;22(5):621-31. [Content Brief]
- [4]. Jacquemin C, et al. OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response. Immunity. 2015 Jun 16;42(6):1159-70. [Content Brief]
- [5]. Hinterbrandner M, et al. Tnfrsf4-expressing regulatory T cells promote immune escape of chronic myeloid leukemia stem cells. JCI Insight. 2021;6(23):e151797.
- [6]. Taylor L, et al. Identification of a soluble OX40 isoform: development of a specific and quantitative immunoassay. J Immunol Methods. 2001 Sep 1;255(1-2):67-72. [Content Brief]
- [7]. Kim TW, et al. First-In-Human Phase I Study of the OX40 Agonist MOXR0916 in Patients with Advanced Solid Tumors. Clin Cancer Res. 2022 Aug 15;28(16):3452-3463. [Content Brief]
All Product Categories
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TNFRSF4 Related Products (5)
Related Products (5)
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Solaprubart
0 ImagesSynonyms: STAR-0310Solaprubart (STAR-0310) is a fully human IgG1 subtype monoclonal antibody targeting OX40 (CD134/TNFRSF4), with a Kd of 7.2 nM. By blocking the OX40/OX40L co-stimulatory signal, Solaprubart effectively inhibits cytokine release (IFN-γ, TNF-α, IL-5, IL-13) from activated effector T cells (Th1/Th2/Th17-associated). Solaprubart can be used in research related to moderate-to-severe atopic dermatitis.
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OX118
0 ImagesCat. No.: HY-P992435OX118 is a fully human, ADCC-enhanced monoclonal antibody targeting OX40L, the recommended isotype control is HY-P99001. OX118 blocks OX40L, suppresses effector T-cell proliferation, expands regulatory T-cell populations, and reduces bystander activation across natural killer cells, B cells, and CD14+ monocytes. OX118 can be used for the research of graft-versus-host disease.
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HLX51
0 ImagesCat. No.: HY-P992368HLX51 is a regulatory T cell inhibitor and OX40/CD134/TNFRSF4 agonist with tumour growth inhibitory activity. HLX51 inhibits regulatory T cell differentiation and activity, relieves tumour microenvironment immunosuppression, enhances effector T cell function. HLX51 competitively binds OX40, activates OX40, promotes immune cell proliferation and T cell killing ability. HLX51 modulates immune cell function to inhibit tumour growth. HLX51 can be used for the research of advanced/metastatic solid tumours and lymphomas.
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MSB013
0 ImagesCat. No.: HY-P992415MSB013 is a recombinant antibody targeting CD134.
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IBI356
0 ImagesCat. No.: HY-P991614IBI356 is a humanized monoclonal antibody inhibitor targeting OX40L/CD134L/CD252. IBI356 can be used to study chronic inflammatory skin diseases, such as atopic dermatitis.
