2. Apoptosis
  3. TNF Receptor
  4. OX118

OX118 is a fully human, ADCC-enhanced monoclonal antibody targeting OX40L, the recommended isotype control is HY-P99001. OX118 blocks OX40L, suppresses effector T-cell proliferation, expands regulatory T-cell populations, and reduces bystander activation across natural killer cells, B cells, and CD14+ monocytes. OX118 can be used for the research of graft-versus-host disease.

For research use only. We do not sell to patients.

OX118

OX118 Chemical Structure

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OX118 Related Antibodies

Top Publications Citing Use of Products

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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Description

OX118 is a fully human, ADCC-enhanced monoclonal antibody targeting OX40L, the recommended isotype control is HY-P99001. OX118 blocks OX40L, suppresses effector T-cell proliferation, expands regulatory T-cell populations, and reduces bystander activation across natural killer cells, B cells, and CD14+ monocytes. OX118 can be used for the research of graft-versus-host disease[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target[1]

OX40L

 

In Vitro

OX118 suppresses CD4+ and CD8+ effector T-cell proliferation, expands CD4+CD25+FOXP3+ regulatory T cells to 43% of the proliferating CD4+ pool, and reduces bystander immune cell activation in allogeneic mixed lymphocyte reactions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

OX118 Related Antibodies
Gene ID

7292  [NCBI]

Accession
Target

TNFSF4/OX40L/CD252
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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OX118 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OX118OX 118OX-118TNF ReceptorTumor Necrosis Factor ReceptorTNFRgraft-versus-host diseaseregulatory T-celleffector T-cellCD14+ monocyteshumanised xenogeneic modelCD8+CD4+B cellsOX40Lnatural killer cellsInhibitorinhibitorinhibit

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HY-P992435
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