TNFSF4 - TNF superfamily member 4 Gene

Also Known as GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L; TNLG2B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7292

About TNFSF4

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:173,172,870-173,450,733 (from NCBI)

This gene has 3 transcripts (splice variants), 95 orthologues and is associated with 3 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

TNFSF4 Products (2)

mRNA	Protein	Name
NM_001297562.2	NP_001284491.1	tumor necrosis factor ligand superfamily member 4 isoform 2
NM_003326.5	NP_003317.1	tumor necrosis factor ligand superfamily member 4 isoform 1

TNFSF4 Protein Structure

TNF

0
100
183 a.a.

Protein Preferred Names	Protein Names
tumor necrosis factor ligand superfamily member 4	CD134 ligand

TNFSF4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TNFSF4	P23510	TNFRSF4	Homo sapiens	P43489	GMS	16905106
Intra	TNFSF4	P23510	TNFRSF4	Homo sapiens	P43489	X-Ray Diffraction	16905106

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFSF4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70622	OX40 Ligand/TNFSF4 Protein, Human (HEK293, His)	P23510-1 (Q51-L183)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77458	OX40 Ligand/TNFSF4 Protein, Human (HEK293, Fc)	P23510-1 (Q51-L183)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78504	OX40 Ligand/TNFSF4 Trimer Protein, Human (HEK293, His-Flag)	P23510-1 (Q51-L183)	≥ 90%, as determined by Bis-Tris PAGE.
HY-P78826	OX40 Ligand/TNFSF4 Protein, Human (Biotinylated, HEK293, Fc-Avi)	P23510-1 (Q51-L183)	≥ 95%, as determined by reducing SDS-PAGE.

TNFSF4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810813	OX40L Antibody (YA10056)	WB	Human
HY-P81730	OX40L Antibody (YA1475)	FC, ELISA	Human

Related Diseases

Diseases	Alias
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Narcolepsy 1	NRCLP1 Narcoleptic Syndrome 1 Gelineau Disease Narcolepsy-Cataplexy Narcolepsy-Cataplexy Syndrome Narcolepsy, Type 1 Narcolepsy Type 1 Cataplexy Gélineau'S Syndrome Narcolepsy With Cataplexy And/Or Hypocretin Deficiency
Scleritis
Immunodeficiency 16	Combined Immunodeficiency Due To Ox40 Deficiency IMD16 Ox40 Deficiency Combined Immunodeficiency With Childhood-Onset Kaposi Sarcoma Combined Immunodeficiency With Impaired Immunity To Hhv-8 Combined Immunodeficiency With Impaired Immunity To Human Herpes Virus 8 Immunodeficiency, Type 16
Cicatricial Ectropion
Narcolepsy	Paroxysmal Sleep Gelineau Syndrome Narcoleptic Syndrome Narcolepsy-Cataplexy Syndrome Cataplexy And Narcolepsy Narcolepsy, Without Cataplexy Gelineau'S Syndrome Narcolepsy With Or Without Cataplexy Narcolepsy Nos
Mouth Disease	Mouth Diseases Mouth Disorders
Blepharoconjunctivitis
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Allergic Conjunctivitis	Conjunctivitis Allergic Conjunctivitis, Allergic Allergen-Induced Conjunctivitis Seasonal Allergic Conjunctivitis Perennial Allergic Conjunctivitis Spring Conjunctivitis Acute Allergic Conjunctivitis
Chronic Conjunctivitis
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14828	TNFSF4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17931	Tnfsf4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24401	Tnfsf4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992122	Olevaprubart		99.43%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TNFSF4	MGD	MGI:104511
Macaca mulatta	TNFSF4	VGNC	VGNC:78598
Felis catus	TNFSF4	VGNC	VGNC:107954
Rattus norvegicus	TNFSF4	RGD	RGD:619816
Canis familiaris	TNFSF4	VGNC	VGNC:47672
Bos taurus	TNFSF4	VGNC	VGNC:36176
Others	TNFSF4	NCBI