TNFSF4 - TNF superfamily member 4 Gene

Homo sapiens

Also known as GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L; TNLG2B

Gene ID: 7292 | Gene type: protein coding

About TNFSF4

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:173,172,870-173,450,733 (from NCBI)

This gene has 3 transcripts (splice variants), 95 orthologues and is associated with 3 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

TNFSF4 Products(2)

mRNA	Protein	Name
NM_001297562.2	NP_001284491.1	tumor necrosis factor ligand superfamily member 4 isoform 2
NM_003326.5	NP_003317.1	tumor necrosis factor ligand superfamily member 4 isoform 1

TNFSF4 Protein Structure

TNF

0
100
183 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor ligand superfamily member 4

CD134 ligand

Recombinant TNFSF4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7565	Recombinant Human OX40/TNFRSF4 (CHO-expressed)	P23510	/
HY-P70622	OX40 Ligand/TNFSF4 Protein, Human (HEK293, His)	P23510 (Q51-L183)	≥95%
HY-P71990	TNFSF4, Human (HEK 293, His)	P23510 (Q51-L183)	≥95%
HY-P77458	OX40 Ligand/TNFSF4 Protein, Human (HEK293, Fc)	P23510 (Q51-L183)	≥95%
HY-P78504	OX40 Ligand/TNFSF4 Protein, Human (HEK293, His-Flag)	P23510 (Q51-L183)	≥95%
HY-P78826	OX40 Ligand/TNFSF4 Protein, Human (Biotinylated, HEK293, Fc-Avi)	P23510 (Q51-L183)	≥95%
HY-P78827	OX40 Ligand/TNFSF4 Protein, Human (Biotinylated, HEK293, His-Avi)	P23510 (Q51-L183)	≥95%

Related Diseases

Diseases

Alias

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Narcolepsy 1

NRCLP1	Narcoleptic Syndrome 1
Gelineau Disease	Narcolepsy-Cataplexy
Narcolepsy-Cataplexy Syndrome	Narcolepsy, Type 1
Narcolepsy Type 1	Cataplexy
Gélineau'S Syndrome	Narcolepsy With Cataplexy And/Or Hypocretin Deficiency

Scleritis

Immunodeficiency 16

Combined Immunodeficiency Due To Ox40 Deficiency	IMD16
Ox40 Deficiency	Combined Immunodeficiency With Childhood-Onset Kaposi Sarcoma
Combined Immunodeficiency With Impaired Immunity To Hhv-8	Combined Immunodeficiency With Impaired Immunity To Human Herpes Virus 8
Immunodeficiency, Type 16

Cicatricial Ectropion

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Mouth Disease

Mouth Diseases

Mouth Disorders

Blepharoconjunctivitis

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Allergic Conjunctivitis

Conjunctivitis Allergic	Conjunctivitis, Allergic
Allergen-Induced Conjunctivitis	Seasonal Allergic Conjunctivitis
Perennial Allergic Conjunctivitis	Spring Conjunctivitis
Acute Allergic Conjunctivitis

Chronic Conjunctivitis

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14828	TNFSF4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TNFSF4	MGD	MGI:104511
Macaca mulatta	TNFSF4	VGNC	VGNC:78598
Felis catus	TNFSF4	VGNC	VGNC:107954
Rattus norvegicus	TNFSF4	RGD	RGD:619816
Canis familiaris	TNFSF4	VGNC	VGNC:47672
Bos taurus	TNFSF4	VGNC	VGNC:36176
Macaca fascicularis	TNFSF4	NCBI
Leporidae	TNFSF4	NCBI
Others	TNFSF4	NCBI

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