2. Apoptosis
  3. TNF Receptor
  4. HLX51

HLX51 is a regulatory T cell inhibitor and OX40/CD134/TNFRSF4 agonist with tumour growth inhibitory activity. HLX51 inhibits regulatory T cell differentiation and activity, relieves tumour microenvironment immunosuppression, enhances effector T cell function. HLX51 competitively binds OX40, activates OX40, promotes immune cell proliferation and T cell killing ability. HLX51 modulates immune cell function to inhibit tumour growth. HLX51 can be used for the research of advanced/metastatic solid tumours and lymphomas.

For research use only. We do not sell to patients.

HLX51

HLX51 Chemical Structure

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HLX51 Related Antibodies

Top Publications Citing Use of Products

View All TNF Receptor Isoform Specific Products:

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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Description

HLX51 is a regulatory T cell inhibitor and OX40/CD134/TNFRSF4 agonist with tumour growth inhibitory activity. HLX51 inhibits regulatory T cell differentiation and activity, relieves tumour microenvironment immunosuppression, enhances effector T cell function. HLX51 competitively binds OX40, activates OX40, promotes immune cell proliferation and T cell killing ability. HLX51 modulates immune cell function to inhibit tumour growth. HLX51 can be used for the research of advanced/metastatic solid tumours and lymphomas[1].

Species Reactivity

Human
IC50 & Target[1]

OX40L

 

In Vitro

HLX51, an agonistic anti-OX40 humanized monoclonal antibody, activates OX40 signaling to promote immune cell proliferation and T cell killing capacity, inhibits Treg function to relieve immunosuppression, and enhances effector T cell function in preclinical in vitro immune cell-based assays[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HLX51 Related Antibodies
Gene ID

7293  [NCBI]

Accession
Target

TNFRSF4/OX40/CD134
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HLX51 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HLX51HLX 51HLX-51TNF ReceptorTumor Necrosis Factor ReceptorTNFROX40/CD134/TNFRSF4Inhibitorinhibitorinhibit

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