TNFRSF4 - TNF receptor superfamily member 4 Gene

Also Known as OX40; ACT35; CD134; IMD16; TXGP1L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7293

About TNFRSF4

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,211,340-1,214,153 (from NCBI)

This gene has 14 transcripts (splice variants), 451 orthologues, 21 paralogues and is associated with 2 phenotypes. Broad expression in fat (RPKM 2.7), lymph node (RPKM 1.6) and 14 other tissues.

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of Apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses Apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

TNFRSF4 Products (2)

mRNA Protein Name
NM_001410709.1 NP_001397638.1 tumor necrosis factor receptor superfamily member 4 isoform 2 precursor
NM_003327.4 NP_003318.1 tumor necrosis factor receptor superfamily member 4 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16905106 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFRSF4 Protein Structure

TNFR_c6

TNFR_c6: TNFR/NGFR cysteine-rich region (31 - 64)

TNFR_c6

TNFR_c6: TNFR/NGFR cysteine-rich region (67 - 107)

  • 0
  • 100
  • 200
  • 277 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 4

  • ACT35 antigen

Recombinant TNFRSF4 Proteins

Cat. No. Product Name Accession Purity
HY-P7394 OX40/TNFRSF4 Protein, Human (HEK293, His) P43489 (L29-A216) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70813 OX40/TNFRSF4 Protein, Human (HEK293, Fc) P43489 (L29-A216) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72404 OX40/TNFRSF4 Protein, Human (Biotinylated, HEK293, Fc-Avi) P43489/NP_003318.1 (L29-A216) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78188 OX40/TNFRSF4 Protein, Human (Biotinylated, HEK293, Fc) P43489 (L29-A216) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78189 OX40/TNFRSF4 Protein, Human (Biotinylated, HEK293, His-Avi) P43489 (L29-A216) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78503 OX40/TNFRSF4 Protein, Human (HEK293, His-Avi) P43489 (L29-A216) ≥ 95%, as determined by Bis-Tris PAGE.

TNFRSF4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81509 CD134/OX40L Recepter Antibody (YA1254) IHC-P Human
HY-P81509A CD134/OX40L Recepter Antibody (YA1254)(PBS only) IHC-P Human
HY-P81759 CD134/OX40L Recepter Antibody (YA1504) FC, ELISA Human
HY-P84330 CD134/OX40L Recepter Antibody (YA4027) IHC-P, FC, ELISA Human
HY-P84330A CD134/OX40L Recepter Antibody (YA4027)(PBS only) IHC-P, FC, ELISA Human
HY-P84961 CD134/OX40L Recepter Antibody (YA4653) WB, ICC/IF, IP, FC Human

Related Diseases

Diseases Alias
Immunodeficiency 16

  • Combined Immunodeficiency Due To Ox40 Deficiency

  • IMD16

  • Ox40 Deficiency

  • Combined Immunodeficiency With Childhood-Onset Kaposi Sarcoma

  • Combined Immunodeficiency With Impaired Immunity To Hhv-8

  • Combined Immunodeficiency With Impaired Immunity To Human Herpes Virus 8

  • Immunodeficiency, Type 16
Kaposi Sarcoma

  • Kaposi'S Sarcoma

  • Kaposi Sarcoma, Susceptibility To

  • Kaposi'S Sarcoma Of Lung

  • Kaposi'S Sarcoma Of Palate

  • Kaposi'S Sarcoma Of Soft Tissue

  • Kaposi'S Sarcoma-Associated Herpesvirus

  • Multiple Idiopathic Pigmented Hemangiosarcoma

  • Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To

  • African Lymphadenopathic Kaposi'S Sarcoma

  • Anal Kaposi'S Sarcoma

  • Cardiac Kaposi'S Sarcoma

  • Central Nervous System Kaposi'S Sarcoma

  • Conjunctival Kaposi'S Sarcoma

  • Corneal Kaposi'S Sarcoma

  • Cutaneous Kaposi'S Sarcoma

  • Esophageal Kaposi'S Sarcoma

  • Gallbladder Kaposi'S Sarcoma

  • Gastric Kaposi'S Sarcoma

  • Intestinal Kaposi'S Sarcoma

  • Kaposi'S Sarcoma Of Anus

  • Kaposi'S Sarcoma Of Central Nervous System

  • Kaposi'S Sarcoma Of Conjunctiva

  • Kaposi'S Sarcoma Of Cornea

  • Kaposi'S Sarcoma Of Esophagus

  • Kaposi'S Sarcoma Of Gastrointestinal Sites

  • Kaposi'S Sarcoma Of Heart

  • Kaposi'S Sarcoma Of Lymph Nodes

  • Kaposi'S Sarcoma Of Penis

  • Kaposi'S Sarcoma Of Skin

  • Kaposi'S Sarcoma Of Soft Tissues

  • Kaposi'S Sarcoma Of The Cns

  • Kaposi'S Sarcoma Of The Gallbladder

  • Kaposi'S Sarcoma Of The Prostate

  • Kaposi'S Sarcoma, Lung

  • Kaposi'S Sarcoma, Skin

  • Lymph Node Kaposi'S Sarcoma

  • Lymphadenopathic Kaposi'S Sarcoma

  • Palate Kaposi'S Sarcoma

  • Penis Kaposi'S Sarcoma

  • Prostate Kaposi'S Sarcoma

  • Pulmonary Kaposi'S Sarcoma

  • Soft Tissue Kaposi'S Sarcoma

  • Hhv8

  • Human Herpesvirus 8

  • Kshv

  • Kaposi Sarcoma Herpesvirus

  • Mediterranean Kaposi Sarcoma

  • Non Aids Related Kaposi Sarcoma

  • Sarcoma, Kaposi

  • Sarcoma, Kaposi, Susceptibility To

  • Non-Aids-Related Kaposi Sarcoma

  • Angiolymphoid Hyperplasia

  • Angiofollicular Ganglionic Hyperplasia

  • Multi-Centric Castleman'S Disease
Myasthenia Gravis

  • MG

  • Acquired Myasthenia

  • Autoimmune Myasthenia Gravis

  • Erb-Goldflam Disease

  • Mg - [Myasthenia Gravis]

  • Myasthenia Gravis Nos

  • Myasthenia
Nodular Goiter

  • Goiter, Nodular

  • Nodular Goitre

  • Goiter Nodular

  • Non-Toxic Nodular Goiter
Autoimmune Disease

  • Autoimmune Diseases

  • Autoimmune Hypersensitivity Disease

  • Hypersensitivity Reaction Type Ii Disease

  • Type Ii Hypersensitivity Reaction Disease
Sarcoma

  • Connective And Soft Tissue Neoplasm

  • Tumor Of Soft Tissue And Skeleton

  • Sarcomas

  • Sarcoma - Category
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
T-Cell Acute Lymphoblastic Leukemia

  • T-Cell Leukemia

  • Acute T Cell Leukemia

  • Precursor T Lymphoblastic Leukemia

  • Precursor T-Lymphoblastic Lymphoma/Leukemia

  • T Acute Lymphoblastic Leukemia

  • T-Cell Acute Lymphocytic Leukaemia

  • T-Cell Lymphoblastic Leukemia/Lymphoma

  • Leukemia T-Cell

  • Leukemia, T-Cell

  • Leukemia, Acute, Lymphoblastic, T-Cell

  • Leukemia, T-Cell Acute Lymphoblastic

  • Leukemia, Acute T-Cell

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Precursor T-Cell Lymphoblastic Lymphoma

  • Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Lymphoproliferative Syndrome 2

  • Cd27 Deficiency

  • LPFS2

  • Combined Immunodeficiency Due To Cd27 Deficiency

  • Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Combined Immunodeficiency

  • Combined T Cell And B Cell Immunodeficiency

  • Congenital Combined Immunodeficiency

  • Syndrome With Combined Immunodeficiency

  • Combined T And B Cell Immunodeficiency

  • Combined Immunity Deficiency

  • Combined Immunodeficiency Syndrome

  • Combined T-Cell And B-Cell Immunodeficiency

  • Lymphopenic Agammaglobulinaemia
Mixed Oligodendroglioma-Astrocytoma

  • Who Grade Ii Mixed Glioma
Soft Palate Cancer

  • Malignant Tumor Of Soft Palate

  • Malignant Tumor Of The Soft Palate

  • Palate Cancer Soft Palate
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991614 IBI356 Inhibitor / Phase 2

Pre-clinical Phase

Inhibitory Antibodies (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992132 Solaprubart Inhibitor 99.59% Unkown
HY-P992415 MSB013 Inhibitor / Unkown
HY-P992435 OX118 Inhibitor / Unkown
HY-P992368 HLX51 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TNFRSF4 MGD MGI:104512
Canis familiaris TNFRSF4 VGNC VGNC:47665
Bos taurus TNFRSF4 VGNC VGNC:36168
Rattus norvegicus TNFRSF4 RGD RGD:3920
Macaca mulatta TNFRSF4 VGNC VGNC:106523
Felis catus TNFRSF4 VGNC VGNC:66411
Others TNFRSF4 NCBI