3057433-10-7
3057433-10-7
Chemical Structure
Solaprubart
Synonym(s): STAR-0310
- CAS No.: 3057433-10-7
- Formula:N/A
- Molecular Weight:145.347 kDa
SMILES: [Solaprubart]
Biological Activity: Solaprubart (STAR-0310) is a fully human IgG1 subtype monoclonal antibody targeting OX40 (CD134/TNFRSF4), with a Kd of 7.2 nM. By blocking the OX40/OX40L co-stimulatory signal, Solaprubart effectively inhibits cytokine release (IFN-γ, TNF-α, IL-5, IL-13) from activated effector T cells (Th1/Th2/Th17-associated). Solaprubart can be used in research related to moderate-to-severe atopic dermatitis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Solaprubart | 99.59% | Solaprubart (STAR-0310) is a fully human IgG1 subtype monoclonal antibody targeting OX40 (CD134/TNFRSF4), with a Kd of 7.2 nM. By blocking the OX40/OX40L co-stimulatory signal, Solaprubart effectively inhibits cytokine release (IFN-γ, TNF-α, IL-5, IL-13) from activated effector T cells (Th1/Th2/Th17-associated). Solaprubart can be used in research related to moderate-to-severe atopic dermatitis. | ||||||||||||||||||||
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References
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[1]. Biris N, et al. Development and characterization of STAR-0310: a novel OX40 antagonistic monoclonal antibody. Cells. 2024;13(7).
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[2]. Biris N, et al. A Dual-Action Mechanism to Prevent OX40 Signaling: The Structural Basis for the Differentiated Antagonist STAR-0310. bioRxiv. 2025 Sep 19:2025-09.
