2. Apoptosis
  3. TNF Receptor
  4. (E)-C-HDMAPP ammonium

(E)-C-HDMAPP ammonium, is a potent phosphoantigen in ammonium form as well as a pyrophosphonate form of (E)-HDMAPP. (E)-C-HDMAPP is also an effective activator of γδ-T cells, induces T-cell stimulatory responses in vitro (EC50=0.91 nM for TNF-α release).

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(E)-C-HDMAPP ammonium Chemical Structure

(E)-C-HDMAPP ammonium Chemical Structure

CAS No. : 933030-60-5

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Based on 1 publication(s) in Google Scholar

(E)-C-HDMAPP ammonium Related Antibodies

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Description

(E)-C-HDMAPP ammonium, is a potent phosphoantigen in ammonium form as well as a pyrophosphonate form of (E)-HDMAPP. (E)-C-HDMAPP is also an effective activator of γδ-T cells, induces T-cell stimulatory responses in vitro (EC50=0.91 nM for TNF-α release)[1][2].

IC50 & Target[1]

TNFRSF1A

 

In Vitro

(E)-C-HDMAPP (compound 5E) (2 μM) increases the release of TNF-α in primary polyclonal human Vγ9Vδ2 T-cell with stimulating bioactivity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(E)-C-HDMAPP ammonium Related Antibodies
In Vivo

(E)-C-HDMAPP (compound 5E) (0.02-10 mg/kg; i.v.; 15 d) provides a significant increase in γδ-cells in cynomolgus model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nonhuman Primate Model in Cynomolgus[1]
Dosage: 0.02 mg/kg, 0.1 mg/kg, 0.5 mg/kg, 2.5 mg/kg, 5 mg/kg, and 10 mg/kg
Administration: Intravenous injection; once with daily s.c. low doses IL-2 to sustain γδ-T-cell proliferation, for 15 days
Result: Significantly increased γδ-cells in vivo at 0.02 mg/kg. Reached maximal effect at 5 mg/kg and 10 mg/kg.
Molecular Weight

311.21

Formula

C6H23N3O7P2
CAS No.
SMILES

OC/C(C)=C/CCP(OP(O)(O)=O)(O)=O.N.N.N
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(E)-C-HDMAPP ammonium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-C-HDMAPP933030-60-5TNF ReceptorTumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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