2. Apoptosis
  3. TNF Receptor
  4. HDMAPP triammonium

HDMAPP triammonium is a potent phosphoantigen in the ammonium form and the pyrophosphate form of (E)-HDMAPP. HDMAPP is also a potent activator of γδ T cells and can induce T cell stimulation in vitro (EC50=0.39 nM, TNF-α).

For research use only. We do not sell to patients.

HDMAPP triammonium Chemical Structure

HDMAPP triammonium Chemical Structure

CAS No. : 443892-56-6

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500 μg USD 178 In-stock

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Based on 1 publication(s) in Google Scholar

HDMAPP triammonium Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

HDMAPP triammonium is a potent phosphoantigen in the ammonium form and the pyrophosphate form of (E)-HDMAPP. HDMAPP is also a potent activator of γδ T cells and can induce T cell stimulation in vitro (EC50=0.39 nM, TNF-α)[1].

IC50 & Target[1]

TNFRSF1A

 

In Vitro

HDMAPP triammonium (compound 3E) (2 μM) increases TNF-α release levels in primary polyclonal human Vγ9Vδ2 T cells and has stimulatory bioactivity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDMAPP triammonium Related Antibodies
In Vivo

HDMAPP triammonium (compound 3E) (0.02-2.5 mg/kg; iv; 15 days) significantly increases γδ cells in a cynomolgus monkey model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nonhuman Primate Model in Cynomolgus[1]
Dosage: 0.02 mg/kg, 0.1 mg/kg, 0.5 mg/kg, 2.5 mg/kg
Administration: Intravenous injection; once with daily s.c. low doses IL-2 to sustain γδ-T-cell proliferation, for 15 days
Result: Significantly increased γδ-cells in vivo at 0.02 mg/kg. Reached maximal effect at 2.5 mg/kg.
Molecular Weight

313.18

Formula

C5H21N3O8P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC/C(C)=C/COP(OP(O)(O)=O)(O)=O.N.N.N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

PBS : 10 mg/mL (31.93 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1931 mL 15.9653 mL 31.9305 mL
5 mM 0.6386 mL 3.1931 mL 6.3861 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥90.0%

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
PBS 1 mM 3.1931 mL 15.9653 mL 31.9305 mL 79.8263 mL
5 mM 0.6386 mL 3.1931 mL 6.3861 mL 15.9653 mL
10 mM 0.3193 mL 1.5965 mL 3.1931 mL 7.9826 mL
15 mM 0.2129 mL 1.0644 mL 2.1287 mL 5.3218 mL
20 mM 0.1597 mL 0.7983 mL 1.5965 mL 3.9913 mL
25 mM 0.1277 mL 0.6386 mL 1.2772 mL 3.1931 mL
30 mM 0.1064 mL 0.5322 mL 1.0644 mL 2.6609 mL
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HDMAPP triammonium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDMAPP triammonium443892-56-6TNF ReceptorTumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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