2. Immunology/Inflammation Apoptosis Metabolic Enzyme/Protease
  3. Interleukin Related TNF Receptor Endogenous Metabolite
  4. Gamma-glutamylcysteine TFA

Gamma-glutamylcysteine TFA  (Synonyms: γ-Glutamylcysteine TFA)

Cat. No.: HY-113402A Purity: 95.06%
COA Handling Instructions

Gamma-glutamylcysteine (γ-Glutamylcysteine) TFA, an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma-glutamylcysteine TFA also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β). Gamma-glutamylcysteine TFA attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes.

For research use only. We do not sell to patients.

Gamma-glutamylcysteine TFA Chemical Structure

Gamma-glutamylcysteine TFA Chemical Structure

CAS No. : 283159-88-6

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5 mg USD 35 In-stock
10 mg USD 55 In-stock
25 mg USD 100 In-stock
50 mg USD 165 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Gamma-glutamylcysteine TFA:

Gamma-glutamylcysteine TFA Related Antibodies

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Description

Gamma-glutamylcysteine (γ-Glutamylcysteine) TFA, an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma-glutamylcysteine TFA also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β). Gamma-glutamylcysteine TFA attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes[1].

IC50 & Target[1]

IL-10

 

IL-6

 

IL-1β

 

Human Endogenous Metabolite

 

Molecular Weight

364.30

Appearance

Solid

Formula

C10H15F3N2O7S
CAS No.
SMILES

SC[C@@H](C(O)=O)NC(CC[C@H](N)C(O)=O)=O.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (274.50 mM; Need ultrasonic)

H2O : 100 mg/mL (274.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7450 mL 13.7250 mL 27.4499 mL
5 mM 0.5490 mL 2.7450 mL 5.4900 mL
10 mM 0.2745 mL 1.3725 mL 2.7450 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.86 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (6.86 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.86 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Gamma-glutamylcysteine TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Gamma-glutamylcysteine283159-88-6γ-GlutamylcysteineInterleukin RelatedTNF ReceptorEndogenous MetaboliteILTumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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