AMPK α2β2γ1
AMPK α2β2γ1 belongs to the AMPK αβγ heterotrimer family that maintains cellular energy homeostasis through isoform-specific complexes[1]. Mechanistically, α2β2γ1 is relevant to skeletal muscle metabolism because human skeletal muscle contains α1β2γ1, α2β2γ1, and α2β2γ3 complexes, but high-intensity exercise selectively activates α2β2γ3 rather than α2β2γ1[2]. Compared with γ3-containing AMPK, γ1 predominates in stabilizing the AMPKα2β2γ1 complex, yet γ1 is dispensable for AICAR- or MK-8722-stimulated glucose uptake in skeletal muscle models[1]. For experimental applications, ADaM-site activators such as PF739 and 991 increase skeletal muscle glucose uptake independently of AMPKγ3, and PF739 selectively activates muscle AMPKγ1 complexes in vivo[3]. SC4 provides a direct α2-focused tool because it preferentially activates α2 complexes, stimulates skeletal muscle glucose uptake, and binds activated α2β2γ1 in structural studies[4].
References:
- [1]. Biswas D, et al. Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle. Mol Metab. 2026 Jan;103:102294. [Content Brief]
- [2]. Birk JB, et al. Predominant alpha2/beta2/gamma3 AMPK activation during exercise in human skeletal muscle. J Physiol. 2006 Dec 15;577(Pt 3):1021-32. [Content Brief]
- [3]. Jørgensen NO, et al. Direct small molecule ADaM-site AMPK activators reveal an AMPKγ3-independent mechanism for blood glucose lowering. Mol Metab. 2021 Sep;51:101259. [Content Brief]
- [4]. Ngoei KRW, et al. Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4. Cell Chem Biol. 2018 Jun 21;25(6):728-737.e9. [Content Brief]
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AMPK α2β2γ1 Related Products (6)
Related Products (6)
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Antibodies (4)
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ZLN024 hydrochloride
0 ImagesZLN024 hydrochloride is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively.
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AMPK-IN-1
0 ImagesCat. No.: HY-120904CAS No.: 1219739-95-3AMPK-IN-1 is an activator of AMPK (EC50: 551 nM for isoform α2β2γ1). AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way.
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AMPK activator 8
0 ImagesCat. No.: HY-147038CAS No.: 1852451-96-7AMPK activator 8 (compound 2) is an AMP-activated protein kinase (AMPK) activator with EC50s of 11, 27, 4, 2, and 4 nM for rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ1, rAMPK α2β2γ3, respectively. AMPK activator 8 can be used for the research of type 2 diabetes.
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AMPK activator 18
0 ImagesCat. No.: HY-115549CAS No.: 1364692-88-5AMPK activator 18 is a potent allosteric activator of AMPK complexes containing the β2 isoform. AMPK activator 18activates α2-containing AMPK α2β2γ1 and α2β2γ3 complexes, with EC50 values of 17.2 and 82.1 nM. AMPK activator 18 stimulates β2-AMPK in cells, and glucose uptake by isolated skeletal muscle. AMPK activator 18 induces acetyl-coenzyme A carboxylase (ACC) and AMPK α-T172 phosphorylation. AMPK activator 18 can be used for the research of type 2 diabetes.
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ZLN024
0 ImagesCat. No.: HY-16708CAS No.: 723249-01-2ZLN024 is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively.
