1. Signaling Pathways
  2. Epigenetics
    PI3K/Akt/mTOR
  3. AMPK
  4. AMPK Isoform
  5. AMPK Activator

AMPK Activator

AMPK Activators (65):

Cat. No. Product Name Effect Purity
  • HY-B0627
    Metformin
    Activator 99.64%
    Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research.
  • HY-13417
    AICAR
    Activator 99.92%
    AICAR (Acadesine) is an adenosine analog and a AMPK activator.
  • HY-17471A
    Metformin hydrochloride
    Activator 99.89%
    Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research.
  • HY-50662
    A-769662
    Activator 98.97%
    A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM, and has little effect on GPPase/FBPase activity.
  • HY-111363
    MK8722
    Activator 99.37%
    MK8722 is a potent and systemic pan-AMPK activator.
  • HY-12357
    Bempedoic acid
    Activator ≥98.0%
    Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor.
  • HY-13417A
    AICAR phosphate
    Activator 99.49%
    AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator.
  • HY-16397A
    Phenformin hydrochloride
    Activator 98.12%
    Phenformin hydrochloride is an anti-diabetic drug from the biguanide class, can activate AMPK activity.
  • HY-14615
    [6]-Gingerol
    Activator 99.45%
    [6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
  • HY-100548
    GSK621
    Activator 98.82%
    GSK621 is a specific AMPK activator, with IC50 values of 13-30 μM for AML cells.
  • HY-N1411
    Platycodin D
    Activator 99.80%
    Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property.
  • HY-136093A
    IM156
    Activator 99.80%
    IM156 (HL156A; HL271 acetate), a chemical derivative of Metformin (HY-B0627), is a potent and orally active AMPK activator that increases AMPK phosphorylation.
  • HY-N2341
    Palmitelaidic Acid
    Activator ≥99.0%
    Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid.
  • HY-136447
    ASP4132
    Activator 98.85%
    ASP4132 is an orally active, potent AMPK activator with an EC50 of 18 nM.
  • HY-B2099A
    Buformin hydrochloride
    Activator 99.91%
    Buformin hydrochloride (1-Butylbiguanide hydrochloride), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent.
  • HY-107988
    MK-3903
    Activator 98.13%
    MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM.
  • HY-134656
    BC1618
    Activator 99.83%
    BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation).
  • HY-112233
    O-304
    Activator 99.53%
    O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK.
  • HY-18555
    TMPA
    Activator 98.22%
    TMPA is a high-affinity Nur77 antagonist that binds to Nur77 leading to the release and shuttling of LKB1 in the cytoplasm to activate AMPKα.
  • HY-112108
    Chitosan oligosaccharide
    Activator
    Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine.