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AICAR phosphate

(Synonyms: Acadesine phosphate; AICA Riboside phosphate)
226 Cited Publications
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Based on 226 publication(s) in Google Scholar

AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor.

For research use only. We do not sell to patients.

  • Purity: 99.97%
  • CAS No.: 681006-28-0
  • Formula: C9H17N4O9P
  • Molecular Weight:356.23
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • AICAR phosphate Chemical Structure
    AICAR phosphate Chemical Structure
  • Experimental Validation Results for AICAR phosphate
  • Experimental Validation Results for AICAR phosphate
  • Experimental Validation Results for AICAR phosphate
  • Experimental Validation Results for AICAR phosphate
  • Experimental Validation Results for AICAR phosphate
  • Experimental Validation Results for AICAR phosphate
  • Experimental Validation Results for AICAR phosphate
  • Experimental Validation Results for AICAR phosphate
  • Experimental Validation Results for AICAR phosphate
  • Experimental Validation Results for AICAR phosphate
CAS No.: 681006-28-0
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  • AICAR phosphate Chemical Structure
    AICAR phosphate Chemical Structure
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    AICAR phosphate purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2024 Jan;40(1-3):16-39. [Abstract]

    Customer Validation
     AICAR (0.5 mM; 12 h) significantly increases the expression of Mfn2 in BUMPT Cells.

  • 1/16

    AICAR phosphate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 May 1;9(5):515. [Abstract]

    Customer Validation
     Protein expression levels of AMPKα, p-AMPKα-thr172, p-ACC-ser79, LC3, Beclin-1, ATG5 and ATG7 in WT MSCs or control CrispCas MSCs, or AMPKα DKO MSCs before and after treatment with FAC or AICAR.

  • 1/16

    AICAR phosphate purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2018 May;41(5):2535-2544. [Abstract]

    Customer Validation
     Cells are treated with AICAR and AICAR (A++, 10 μM) + Compound C (C++, 1 μM) for 24 h, after which western blot analysis is performed.

  • 1/16

    AICAR phosphate purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2018 May;41(5):2535-2544. [Abstract]

    Customer Validation
     MC3T3-E1 cells are treated with AICAR (10 μM) in the presence or absence of 3-MA (5 mM) or CQ (10 μM) for 24 h, after which western blot analysis is conducted.

  • 1/16

    AICAR phosphate purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Apr 16:9:345. [Abstract]

    Customer Validation
     AMP-activated protein kinase (AMPK) activation by AST blunts dysfunction of lipid metabolism and resistance in HepG2 cells. Representative bands of SREBP-1c nuclear protein and cytoplasmic proteins are visualized in the immunoblotting assay.

  • 1/16

    AICAR phosphate purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Apr 16:9:345. [Abstract]

    Customer Validation
     AMP-activated protein kinase activation by AST inhibits the expression of sterol regulatory element binding protein-1c (SREBP-1c) and SREBP-1c related genes. AST promotes AMPKa1 mRNA expression, AMPKa2 mRNA expression, and suppresses the expression of SREBP-1c, and its downstream genes FAS, ACC1, and also AMPK downstream gene SCD1.

  • 1/16

    AICAR phosphate purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Jul 16:9:761. [Abstract]

    Customer Validation
     Epithelial cells from colon tissue are extracted from mice in each group (n=6-8 per group) and protein level of p-AMPK (Thr172) and AMPKα1/2 are measured by western blot.

  • 1/16

    AICAR phosphate purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3723-3738. [Abstract]

    Customer Validation
     The effect of AICAR on the expression of AMPK, p-AMPK, mTOR, p-mTOR, and autophagy-related protein by Western blot analysis.

  • 1/16

    AICAR phosphate purchased from MedChemExpress. Usage Cited in: J Cell Physiol. 2018 Dec;233(12):9701-9715. [Abstract]

    Customer Validation
     HUVECs are pretreated with Compound C (5, 10, or 20 μM) for 18 hr or AICAR (1, 2, or 4 mM) for 1 hr, and then exposed to LSS for 30 min.

  • 1/16

    AICAR phosphate purchased from MedChemExpress. Usage Cited in: Acta Biochim Biophys Sin (Shanghai). 2018 Feb 1;50(2):144-155. [Abstract]

    Customer Validation
     Raw264.7 macrophages with serum deprivation are treated with 50 μM Rg1 for 48 h in absence or presence of compound C (10 mM) or AICAR (250 μM). Western blots of the protein expressions of Atg5, Beclin1, LC3, and p62/SQSMT1.

  • AICAR phosphate