114-86-3
Chemical Structure
Phenformin
Synonym(s): Phenethylbiguanide
- CAS No.: 114-86-3
- Formula:C10H15N5
- Molecular Weight:205.26
InChIKey: ICFJFFQQTFMIBG-UHFFFAOYSA-N
SMILES: NC(NC(NCCC1=CC=CC=C1)=N)=N
Biological Activity: Phenformin (Phenethylbiguanide) is an orally active biguanide hypoglycemic agent. Phenformin inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy. Phenformin inhibits cancer stem cells (CSCs) and possesses potent antitumor potential[1][2][3][4].
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Phenformin | 98.02% | Phenformin (Phenethylbiguanide) is an orally active biguanide hypoglycemic agent. Phenformin inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy. Phenformin inhibits cancer stem cells (CSCs) and possesses potent antitumor potential. | ||||||||||||||||||||
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Phenformin (Standard) | ≥98% | Phenformin (Phenethylbiguanide) (Standard) is the analytical standard of Phenformin (HY-16397). This product is intended for research and analytical applications. Phenformin (Phenethylbiguanide) is an orally active biguanide hypoglycemic agent. Phenformin inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy. Phenformin inhibits cancer stem cells (CSCs) and possesses potent antitumor potential. | ||||||||||||||||||||
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- [1]. García Rubiño ME, et al. Phenformin as an Anticancer Agent: Challenges and Prospects. Int J Mol Sci. 2019;20(13):3316. Published 2019 Jul 5. [Content Brief]
- [2]. Alves-Silva AB, et al. Phenformin increases early hematopoietic progenitors in the Jak2V617F murine model. Invest New Drugs. 2022;40(3):576-585. [Content Brief]
- [3]. Hu S, et al. Phenformin inhibits cell proliferation and induces cell apoptosis and autophagy in cholangiocarcinoma. Mol Med Rep. 2018;17(4):6028-6032. [Content Brief]
- [4]. Yendapally R, et al. A review of phenformin, metformin, and imeglimin. Drug Dev Res. 2020;81(4):390-401. [Content Brief]
Keywords
