2. Metabolic Enzyme/Protease Apoptosis PI3K/Akt/mTOR Epigenetics
  3. Apoptosis Mitochondrial Metabolism AMPK
  4. Phenformin

Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis.

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Phenformin Chemical Structure

Phenformin Chemical Structure

CAS No. : 114-86-3

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Phenformin Related Antibodies

Top Publications Citing Use of Products

    Phenformin purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2020 Aug;128:110216.  [Abstract]

    Western blot analysis of p-AMPK, LC3B-I/II and NLRP3 after PSCs are pretreated with phenformin (Phe, AMPK activator) for 1 h followed by incubation with or without 10 μg/mL SSa for 24 h.

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    Description

    Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis[1][2].

    Molecular Weight

    205.26

    Formula

    C10H15N5
    CAS No.
    SMILES

    NC(NC(NCCC1=CC=CC=C1)=N)=N
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
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    Phenformin Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Phenformin114-86-3PhenethylbiguanideApoptosisMitochondrial MetabolismAMPKAMP-activated protein kinasetype 2 diabetes mellitusInhibitorinhibitorinhibit

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