Cat. No.: HY-L230

FDA Kinase Inhibitor Library

78 Cited Publications

Customer Review

Based on 78 publication(s) in Google Scholar

Kinases are enzymes that catalyze the addition of phosphate groups to substrate molecules, a process known as phosphorylation. Protein phosphorylation serves as a critical regulatory mechanism for numerous cellular processes, including cell division, metabolism, and signal transduction. The human genome encodes over 500 kinases, which collectively regulate approximately 50% of cellular functions. Due to their pivotal roles, kinases represent one of the most important target classes in drug development.

Kinase inhibitors can selectively block the activity of disease-associated kinases, making them valuable therapeutics for conditions such as cancer and inflammatory diseases. FDA-approved kinase inhibitors have undergone extensive preclinical and clinical studies, demonstrating high bioactivity, favorable safety profiles, and good bioavailability, rendering them suitable for investigating new therapeutic indications.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, and 2 mM for compounds with solubility between 2 mM and 10 mM.

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Description & Advantages
Product Details
- Formulation
- Layout
- Container
- Storage
- Shipping
Publications (78)
Documentation
Composition

Description & Advantages

• A unique collection of 332 approved kinase inhibitors for high throughput screening (HTS) and high content screening (HCS).

• Kinase inhibitors have played an increasingly prominent role in the treatment of cancer and other diseases.

• Bioactivity and safety confirmed by preclinical research and clinical trials.

• Structurally diverse, medicinally active, and cell permeable.

• Rich documentation with structure, IC₅₀, and customer reviews.

• NMR and HPLC validated to ensure high purity.

• All compounds are in stock and continuously updated.

Product Details

Formulation

A collection of 332 marketed kinase inhibitors supplied as pre-dissolved Solutions or Solid

Solution: 318 compounds supplied in 10 mM solution, 14 compounds supplied in 2 mM solution.

Layout

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates.
This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage

-80°C

Shipping

Blue ice or dry ice