72-48-0
72-48-0
Chemical Structure
Alizarin
- No. CAS: 72-48-0
- Formula:C14H8O4
- Molecular Weight:240.21
IUPAC Name: 1,2-dihydroxyanthracene-9,10-dione
InChIKey: RGCKGOZRHPZPFP-UHFFFAOYSA-N
SMILES: O=C1C2=C(C=CC=C2)C(C3=CC=C(O)C(O)=C13)=O
Biological Activity: Alizarin is a natural dye. Alizarin can be extracted from the roots of madder plant. Alizarin activates AMPK and VEGFR2/eNOS pathway. Alizarin regulates PI3K/Akt and inhibits NF-κB pathway. Alizarin enhances CYP1A1 enzyme activity. Alizarin has protective effects on hypertension and vascular endothelial dysfunction. Alizarin has anti-tumor activity against multiple cancers including pancreatic cancer, breast cancer, osteosarcoma and liver cancer. Alizarin has been widely used as a pigment in textile fabrics and paintings[1][2][3][4][5][6][7].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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Alizarin | 99.48% | Alizarin is a natural dye. Alizarin can be extracted from the roots of madder plant. Alizarin activates AMPK and VEGFR2/eNOS pathway. Alizarin regulates PI3K/Akt and inhibits NF-κB pathway. Alizarin enhances CYP1A1 enzyme activity. Alizarin has protective effects on hypertension and vascular endothelial dysfunction. Alizarin has anti-tumor activity against multiple cancers including pancreatic cancer, breast cancer, osteosarcoma and liver cancer. Alizarin has been widely used as a pigment in textile fabrics and paintings. | ||||||||||||||||||||
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Alizarin (Standard) | 96.56% | Alizarin (Standard) is the analytical standard of Alizarin. This product is intended for research and analytical applications. Alizarin is a natural dye extracted from the roots of madder plant and has been widely used as a pigment in textile fabrics and paintings. | ||||||||||||||||||||
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Anthragallol | 99.55% | Anthragallol can insert base pairs of DNA. Anthragallol exhibits cytotoxicity by binding to DNA. | ||||||||||||||||||||
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Alizarin 2-methyl ether | Alizarin 2-methyl ether is a DNA topoisomerase inhibitor. Alizarin 2-methyl ether inhibits the relaxation of supercoiled DNA via DNA topoisomerase I and II. Alizarin 2-methyl ether promotes adipocyte differentiation by increasing lipid accumulation. Alizarin 2-methyl ether possesses antidiabetic and insulin-sensitizing properties. Alizarin 2-methyl ether can be used in research related to human colon cancer, P-388 lymphocytic leukemia and diabetes. | |||||||||||||||||||||
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Quinizarin | 98.84% | Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (Kd=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth. | ||||||||||||||||||||
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Rubiadin | 99.56% | Rubiadin is an orally active free radical scavenger that inhibits the activation of the NF-κB pathway. Rubiadin inhibits osteoclast formation, bone resorption, lipid peroxidation, HBV DNA replication and cancer cell proliferation; reduces pro-inflammatory cytokine levels; induces cancer cell apoptosis; and possesses antifungal, antimalarial, antibacterial and anticonvulsant activities. Rubiadin can be used in the research of osteoporosis, acute inflammation, chronic inflammation, carbon tetrachloride-induced liver injury, Alzheimer's disease, breast cancer, iron overload disorders, hepatitis B virus infection, colon cancer, liver cancer, T-lymphocytic leukemia, cervical cancer, diabetic nephropathy, epileptic seizures, fungal infections, malaria and bacterial infections. | ||||||||||||||||||||
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Purpurin | 99.21% | Purpurin is a natural anthraquinone compound from Rubia cordifolia L.. Purpurin has antidepressant-like effects. | ||||||||||||||||||||
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1-Hydroxy-2-methylanthraquinone | 1-Hydroxy-2-methylanthraquinone exhibits antimicrobial, antioxidant, pesticidal, and anti-inflammatory activities. | |||||||||||||||||||||
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2-Hydroxy-1-methoxyanthraquinone | 99.98% | 2-Hydroxy-1-methoxyanthraquinone could be isolated from the stem bark of Morinda lucida Benth. (Rubiaceae) and possesses antibacterial activity. |
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Xanthopurpurin | 97.03% | Xanthopurpurin is an orally active anthraquinone glycoside. Xanthopurpurin can be isolated from the rhizome of Rubia akane. Xanthopurpurin has antiviral effects against rotavirus and HIV. Xanthopurpurin has a strong inhibitory effect on collagen-induced platelet aggregation. Xanthopurpurin prevents peanut allergy. | ||||||||||||||||||||
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1-Hydroxyanthraquinone (Standard) | ≥98% | 1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect. | ||||||||||||||||||||
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Anthrarufin | 90.0% | Anthrarufin (9,10-Anthracenedione, 1,5-dihydroxy-_) is an anthraquinone compound that has an inhibitory effect on the activity of the uterine mucosa during pregnancy. | ||||||||||||||||||||
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References
- [1]. Xu Z, et al. Alizarin, a nature compound, inhibits the growth of pancreatic cancer cells by abrogating NF-κB activation. Int J Biol Sci. 2022 Mar 28;18(7):2759-2774. [Content Brief]
- [2]. Liang S, et al. Alizarin, an Agonist of AHR Receptor, Enhances CYP1A1 Enzyme Activity and Induces Transcriptional Changes in Hepatoma Cells. Molecules. 2023 Oct 31;28(21):7373. [Content Brief]
- [3]. Fotia C, et al. The natural compound Alizarin as an osteotropic drug for the treatment of bone tumors. J Orthop Res. 2012 Sep;30(9):1486-92. [Content Brief]
- [4]. Xu L, et al. Alizarin increase glucose uptake through PI3K/Akt signaling and improve alloxan-induced diabetic mice. Future Med Chem. 2019 Mar;11(5):395-406. [Content Brief]
- [5]. Qian YW, et al. The antihypertensive effect of Alizarin is achieved by activating VEGFR2/eNOS pathway, attenuating oxidative stress-induced mitochondrial damage and premature senescence. Life Sci. 2024 Aug 15;351:122862. [Content Brief]
- [6]. Zhu ML, et al. Protective effect of alizarin on vascular endothelial dysfunction via inhibiting the type 2 diabetes-induced synthesis of THBS1 and activating the AMPK signaling pathway. Phytomedicine. 2024 Jun;128:155557. [Content Brief]
- [7]. Jen M, et al. Ultrafast Intramolecular Proton Transfer of Alizarin Investigated by Femtosecond Stimulated Raman Spectroscopy. J Phys Chem B. 2017 Apr 27;121(16):4129-4136. [Content Brief]
