Quinizarin
Based on 1 Customer Validation
Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (Kd=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth.
For research use only. We do not sell to patients.
- Purity: 98.84%
- CAS No.: 81-64-1
- Formula: C14H8O4
- Molecular Weight:240.21
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
>30 μg/mL
Compound: DHAQ
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Inhibitory concentration required against A 431 human epidermoid carcinoma cell line
Inhibitory concentration required against A 431 human epidermoid carcinoma cell line
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[PMID: 11354370] |
| A549 | IC50 |
>200 μM
Compound: Quinizarin
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Inhibition of topoisomerase 2 in human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Inhibition of topoisomerase 2 in human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
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[PMID: 30846253] |
| B16 | IC50 |
>30 μg/mL
Compound: DHAQ
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Inhibitory concentration against B16 murine melanoma cell line
Inhibitory concentration against B16 murine melanoma cell line
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[PMID: 11354370] |
| Ca-Ski | IC50 |
>10 μM
Compound: 1
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Cytotoxicity against human CaSki cells after 72 hrs by MTT assay
Cytotoxicity against human CaSki cells after 72 hrs by MTT assay
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[PMID: 24657570] |
| HCT-116 | IC50 |
>30 μg/mL
Compound: DHAQ
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Inhibitory concentration against HCT 116 human colon cancer cell line
Inhibitory concentration against HCT 116 human colon cancer cell line
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[PMID: 11354370] |
| HeLa | IC50 |
>200 μM
Compound: Quinizarin
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Inhibition of topoisomerase 2 in human HeLa cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Inhibition of topoisomerase 2 in human HeLa cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
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[PMID: 30846253] |
| HepG2 | IC50 |
>200 μM
Compound: Quinizarin
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Inhibition of topoisomerase 2 in human HepG2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Inhibition of topoisomerase 2 in human HepG2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
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[PMID: 30846253] |
| L02 | IC50 |
>200 μM
Compound: Quinizarin
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Cytotoxicity against human L02 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
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[PMID: 30846253] |
| MCF7 | IC50 |
>200 μM
Compound: Quinizarin
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Inhibition of topoisomerase 2 in human MCF7 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Inhibition of topoisomerase 2 in human MCF7 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
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[PMID: 30846253] |
| MDA-MB-231 | IC50 |
>200 μM
Compound: Quinizarin
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Inhibition of topoisomerase 2 in human MDA-MB-231 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Inhibition of topoisomerase 2 in human MDA-MB-231 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
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[PMID: 30846253] |
1,4-Dihydroxyanthraquinone (1,4-DHAQ, a fluorophore) doped cellulose (CL) (denoted as 1,4-DHAQ@CL) microporous nanofiber film has been achieved via simple electrospinning and subsequent deacetylating, and used for highly sensitive and selective fluorescence detection of Cu2+ in aqueous solution[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Chemical Information
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CAS No. 81-64-1
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Appearance Solid
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Molecular Weight 240.21
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Formula C14H8O4
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Color Orange to red
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SMILES
O=C1C2=C(C=CC=C2)C(C3=C(O)C=CC(O)=C13)=O
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Synonyms
1,4-Dihydroxyanthraquinone
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 3.33 mg/mL (13.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
- Español - ES (458 KB)
- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Korean - KR (458 KB)
- Portuguese - PT (458 KB)
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Handling Instructions (2659 KB)
References
[1]. Verebová V, et al. Anthraquinones quinizarin and danthron unwind negatively supercoiled DNA and lengthen linear DNA. Biochem Biophys Res Commun. 2014;444(1):50-55. [Content Brief]
[2]. Dominic Cheuk, et al. Investigation into solid and solution properties of quinizarin.
[3]. Wang M, et al. Electrospun 1,4-DHAQ-doped cellulose nanofiber films for reusable fluorescence detection of trace Cu2+ and further for Cr3+. Environ Sci Technol. 2012;46(1):367-373. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1630 mL | 20.8151 mL | 41.6302 mL | 104.0756 mL |
| 5 mM | 0.8326 mL | 4.1630 mL | 8.3260 mL | 20.8151 mL | |
| 10 mM | 0.4163 mL | 2.0815 mL | 4.1630 mL | 10.4076 mL |
Quinizarin Related Classifications
HY-D0226 Related Classifications
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