Xanthopurpurin
Based on 1 Customer Validation
Xanthopurpurin is an orally active anthraquinone glycoside. Xanthopurpurin can be isolated from the rhizome of Rubia akane. Xanthopurpurin has antiviral effects against rotavirus and HIV. Xanthopurpurin has a strong inhibitory effect on collagen-induced platelet aggregation. Xanthopurpurin prevents peanut allergy.
For research use only. We do not sell to patients.
- Purity: 97.03%
- CAS No.: 518-83-2
- Formula: C14H8O4
- Molecular Weight:240.21
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
29 μM
Compound: 7, xanthopurpurin
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Cytotoxicity against Homo sapiens (human) DU145 cells assessed as inhibition of cell survival after 96 hr by MTT assay
Cytotoxicity against Homo sapiens (human) DU145 cells assessed as inhibition of cell survival after 96 hr by MTT assay
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10.1007/s00044-012-0197-5 |
| MCF7 | IC50 |
55 μM
Compound: 7, xanthopurpurin
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Cytotoxicity against Homo sapiens (human) MCF7 cells assessed as inhibition of cell survival after 96 hr by MTT assay
Cytotoxicity against Homo sapiens (human) MCF7 cells assessed as inhibition of cell survival after 96 hr by MTT assay
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10.1007/s00044-012-0197-5 |
| MES-SA | IC50 |
30 μM
Compound: 7, xanthopurpurin
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Cytotoxicity against Homo sapiens (human) MES-SA cells assessed as inhibition of cell survival after 96 hr by MTT assay
Cytotoxicity against Homo sapiens (human) MES-SA cells assessed as inhibition of cell survival after 96 hr by MTT assay
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10.1007/s00044-012-0197-5 |
| MES-SA/Dx5 | IC50 |
21 μM
Compound: 7, xanthopurpurin
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Cytotoxicity against Homo sapiens (human) MES-SA/Dx5 cells assessed as inhibition of cell survival after 96 hr by MTT assay
Cytotoxicity against Homo sapiens (human) MES-SA/Dx5 cells assessed as inhibition of cell survival after 96 hr by MTT assay
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10.1007/s00044-012-0197-5 |
| NCI-H460 | IC50 |
23 μM
Compound: 7, xanthopurpurin
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Cytotoxicity against Homo sapiens (human) H460 cells assessed as inhibition of cell survival after 96 hr by MTT assay
Cytotoxicity against Homo sapiens (human) H460 cells assessed as inhibition of cell survival after 96 hr by MTT assay
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10.1007/s00044-012-0197-5 |
Xanthopurpurin (2.5-40 μg/mL) inhibits IgE production in a dose-dependent manner in human myeloma U266 cells[1].
Xanthopurpurin (15 μg/mL) shows 42% inhibition of HIV in CEM-GFP cells infected with HIV-1[2].
Xanthopurpurin is very efficient against rotavirus in MA104 cells by enhancing virus-mediated apoptosis and suppressing its proliferation[3].
Xanthopurpurin shows strong inhibition of collagen-induced platelet aggregation in washed rabbit platelets[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six-week-old female C3H/HeJ mice, peanut-allergic murine model[1]
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Dosage:200 μg or 400 μg per mouse per day (dissolved in drinking water)
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Administration:Orally administered, for 4 weeks
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Result:Significantly reduced peanut-specific IgE levels, plasma histamine levels, and protected the mice against peanut-allergic reactions in both early and late treatment experiments.
Increased IL-4 promoter methylation, reduced the number of peripheral and bone marrow IgE+ B cells, and regulated the gene expression of CCND1, DUSP4, SDC1, ETS1, PTPRC, and IL6R related to plasma cell IgE production.
Chemical Information
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CAS No. 518-83-2
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Appearance Solid
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Molecular Weight 240.21
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Formula C14H8O4
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Color White to yellow
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SMILES
O=C1C2=C(C=CC=C2)C(C3=CC(O)=CC(O)=C13)=O
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Synonyms
Purpuroxanthin
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : ≥ 50 mg/mL (208.15 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (5.20 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Yang N, et al. Sustained silencing peanut allergy by xanthopurpurin is associated with suppression of peripheral and bone marrow IgE-producing B cell. Front Immunol. 2024 Feb 6;15:1299484. [Content Brief]
[2]. Sabde S, et al. Anti-HIV activity of Indian medicinal plants. J Nat Med. 2011 Jul;65(3-4):662-9. [Content Brief]
[3]. Rahman MM, et al. Multifunctional Therapeutic Potential of Phytocomplexes and Natural Extracts for Antimicrobial Properties. Antibiotics (Basel). 2021 Sep 6;10(9):1076. [Content Brief]
[4]. Chung MI, et al. Antiplatelet constituents of formosan Rubia akane. J Nat Prod. 1994 Feb;57(2):313-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1630 mL | 20.8151 mL | 41.6302 mL | 104.0756 mL |
| 5 mM | 0.8326 mL | 4.1630 mL | 8.3260 mL | 20.8151 mL | |
| 10 mM | 0.4163 mL | 2.0815 mL | 4.1630 mL | 10.4076 mL | |
| 15 mM | 0.2775 mL | 1.3877 mL | 2.7753 mL | 6.9384 mL | |
| 20 mM | 0.2082 mL | 1.0408 mL | 2.0815 mL | 5.2038 mL | |
| 25 mM | 0.1665 mL | 0.8326 mL | 1.6652 mL | 4.1630 mL | |
| 30 mM | 0.1388 mL | 0.6938 mL | 1.3877 mL | 3.4692 mL | |
| 40 mM | 0.1041 mL | 0.5204 mL | 1.0408 mL | 2.6019 mL | |
| 50 mM | 0.0833 mL | 0.4163 mL | 0.8326 mL | 2.0815 mL | |
| 60 mM | 0.0694 mL | 0.3469 mL | 0.6938 mL | 1.7346 mL | |
| 80 mM | 0.0520 mL | 0.2602 mL | 0.5204 mL | 1.3009 mL | |
| 100 mM | 0.0416 mL | 0.2082 mL | 0.4163 mL | 1.0408 mL |
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