1. Epigenetics
    Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. AMPK
  3. Palmitelaidic Acid

Palmitelaidic Acid (Synonyms: 9-trans-Hexadecenoic acid; trans-Palmitoleic acid)

Cat. No.: HY-N2341 Purity: >99.0%
Handling Instructions

Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.

For research use only. We do not sell to patients.

Palmitelaidic Acid Chemical Structure

Palmitelaidic Acid Chemical Structure

CAS No. : 10030-73-6

Size Price Stock Quantity
10 mg (393 mM * 100 μL in Ethanol) USD 60 In-stock
Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

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Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.

IC50 & Target[2]







In Vitro

The monounsaturated fatty acid palmitoleate (palmitoleic acid) is one of the most abundant fatty acids in serum and tissues, particularly adipose tissue and liver. Its endogenous production by stearoyl-CoA desaturase 1 gives rise to its cis isoform, cis-palmitoleate. Palmitoleic acid has been correlated with multiple cardiometabolic risk factors, including high blood pressure, total cholesterol, TGs, apoA-I, apoB, and endothelial dysfunction[1].

In Vivo

Palmitoleic acid promotes a faster uptake of glucose in the body, associated with higher insulin concentration. Palmitoleic acid increases the phosphorylation of AMPK, up-regulates glucokinase and down-regulates SREBP-1. Regarding AMPK downstream, palmitoleic acid increases the production of FGF-21 and stimulates the expression of PPARα[2]. Palmitoleic acid reduces body weight increase, ameliorates the development of hyperglycemia and hypertriglyceridemia, and improves insulin sensitivity. Furthermore, palmitoleic acid down-regulates mRNA expressions of proinflammatory adipocytokine genes (TNFα and resistin) in white adipose tissue and lipogenic genes (SREBP-1, FAS, and SCD-1) in liver[3].

Molecular Weight









Room temperature in continental US; may vary elsewhere.


Solution, -20°C, 2 years

Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (393.07 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9307 mL 19.6533 mL 39.3066 mL
5 mM 0.7861 mL 3.9307 mL 7.8613 mL
10 mM 0.3931 mL 1.9653 mL 3.9307 mL
*Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Mice: Male C57BL/6J wild type and PPARα-KO mice are fed a high-fat diet or a standard diet for 12 weeks. In the last two weeks, the HF-fed mice are treated daily with oleic acid (300 mg/kg of body weight) or palmitoleic acid (00 mg/kg of body weight) by oral gavage. After 12 weeks, the mice are fasted for 6 h, injected with insulin or PBS vehicle. Blood and liver samples are collected and stored for the further analysis of RNA and protein expression[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Purity: >99.0%

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Palmitelaidic Acid9-trans-Hexadecenoic acidtrans-Palmitoleic acidAMPKPPARGlucokinaseAMP-activated protein kinasePeroxisome proliferator-activated receptorsHexokinase IVHexokinase DInhibitorinhibitorinhibit

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