2. Epigenetics PI3K/Akt/mTOR Metabolic Enzyme/Protease Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor
  3. AMPK PPAR Glucokinase
  4. Palmitelaidic acid

Palmitelaidic acid  (Synonyms: 9-trans-Hexadecenoic acid; trans-Palmitoleic acid)

Cat. No.: HY-N2341 Purity: 99.4%
COA
SDS
Handling Instructions Technical Support

Palmitelaidic acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.

For research use only. We do not sell to patients.

Palmitelaidic acid

Palmitelaidic acid Chemical Structure

CAS No. : 10030-73-6

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Solvent
10 mg (393 mM * 100 μL in Ethanol) In-stock
Solvent
25 mg (393 mM * 250 μL in Ethanol) In-stock
Solvent
50 mg (393 mM * 500 μL in Ethanol) In-stock

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Palmitelaidic acid:

Palmitelaidic acid Related Antibodies

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  • Biological Activity

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  • Purity & Documentation

  • References

  • Customer Review

Description

Palmitelaidic acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.

IC50 & Target[2]

AMPK

 

PPARα

 

Glucokinase

 

In Vitro

The monounsaturated fatty acid palmitoleate (palmitoleic acid) is one of the most abundant fatty acids in serum and tissues, particularly adipose tissue and liver. Its endogenous production by stearoyl-CoA desaturase 1 gives rise to its cis isoform, cis-palmitoleate. Palmitoleic acid has been correlated with multiple cardiometabolic risk factors, including high blood pressure, total cholesterol, TGs, apoA-I, apoB, and endothelial dysfunction[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Palmitelaidic acid Related Antibodies
In Vivo

Palmitoleic acid promotes a faster uptake of glucose in the body, associated with higher insulin concentration. Palmitoleic acid increases the phosphorylation of AMPK, up-regulates glucokinase and down-regulates SREBP-1. Regarding AMPK downstream, palmitoleic acid increases the production of FGF-21 and stimulates the expression of PPARα[2]. Palmitoleic acid reduces body weight increase, ameliorates the development of hyperglycemia and hypertriglyceridemia, and improves insulin sensitivity. Furthermore, palmitoleic acid down-regulates mRNA expressions of proinflammatory adipocytokine genes (TNFα and resistin) in white adipose tissue and lipogenic genes (SREBP-1, FAS, and SCD-1) in liver[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

254.41

Formula

C16H30O2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCCC/C=C/CCCCCCCC(O)=O
Structure Classification
Initial Source

 beef samples
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: 99.4%

SDS (393 KB)

COA (238 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[2]

Mice: Male C57BL/6J wild type and PPARα-KO mice are fed a high-fat diet or a standard diet for 12 weeks. In the last two weeks, the HF-fed mice are treated daily with oleic acid (300 mg/kg of body weight) or palmitoleic acid (00 mg/kg of body weight) by oral gavage. After 12 weeks, the mice are fasted for 6 h, injected with insulin or PBS vehicle. Blood and liver samples are collected and stored for the further analysis of RNA and protein expression[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Palmitelaidic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Palmitelaidic acid10030-73-69-trans-Hexadecenoic acid trans-Palmitoleic acidAMPKPPARGlucokinaseAMP-activated protein kinasePeroxisome proliferator-activated receptorsHexokinase IVHexokinase DInhibitorinhibitorinhibit

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