1346607-05-3
1346607-05-3
Chemical Structure
GSK621
- CAS No.: 1346607-05-3
- Formula:C26H20ClN3O5
- Molecular Weight:489.91
IUPAC Name: 6-chloro-5-(2'-hydroxy-3'-methoxy-[1,1'-biphenyl]-4-yl)-3-(3-methoxyphenyl)-1,5-dihydro-2H-pyrrolo[3,2-d]pyrimidine-2,4(3H)-dione
InChIKey: KURYSXLJGKKDHT-UHFFFAOYSA-N
SMILES: O=C1NC2=C(N(C3=CC=C(C4=CC=CC(OC)=C4O)C=C3)C(Cl)=C2)C(N1C5=CC=CC(OC)=C5)=O
Biological Activity: GSK621 is a specific AMPK activator, with IC50 values of 13-30 μM for AML cells. GSK621 induces autophagy and apoptosis. GSK621 induces eiF2α phosphorylation-a hallmark of UPR activation[1].
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GSK621 | 98.03% | GSK621 is a specific AMPK activator, with IC50 values of 13-30 μM for AML cells. GSK621 induces autophagy and apoptosis. GSK621 induces eiF2α phosphorylation-a hallmark of UPR activation. | ||||||||||||||||||||
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References
Keywords
