1. Epigenetics
    PI3K/Akt/mTOR
  2. AMPK

O-304 

Cat. No.: HY-112233 Purity: 98.63%
Handling Instructions

O-304 is a small molecule AMPK activator.

For research use only. We do not sell to patients.

O-304 Chemical Structure

O-304 Chemical Structure

CAS No. : 1261289-04-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 198 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
10 mg USD 280 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
25 mg USD 550 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 850 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
100 mg USD 1300 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

O-304 is a small molecule AMPK activator.

IC50 & Target

AMPK[1]

In Vivo

O-304 efficiently increases glucose uptake and reduces insulin resistance in skeletal muscle a primary cause of obesity-induced T2D. O-304 also reverses β-cell stress/dysfunction and induce β-cell rest. O-304 also increases energy expenditure and protects against diet induced obesity, fatty liver, hyperlipidemia and diabetes. CVD remains a major cause of death of T2 diabetics, and O-304 increases peripheral blood flow and left ventricular function, and acts as an “Exercise mimetic”. Thus, as an AMPK activator O-304 uniquely mitigates many of the metabolic and cardiovascular complications associated with the obesity epidemic. O-304 has the unique potential to increase glucose uptake and reduce insulin resistance in newly diagnosed T2 diabetics and as such prevent the associated β-cell hyperactivity/failure and progression of the disease[1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.6298 mL 13.1492 mL 26.2985 mL
5 mM 0.5260 mL 2.6298 mL 5.2597 mL
10 mM 0.2630 mL 1.3149 mL 2.6298 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

380.25

Formula

C₁₆H₁₁Cl₂N₃O₂S

CAS No.

1261289-04-6

SMILES

O=C(NC(SN1CC2=CC=C(Cl)C=C2)=NC1=O)C3=CC=C(Cl)C=C3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 30 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
O-304
Cat. No.:
HY-112233
Quantity: