1. Epigenetics
    PI3K/Akt/mTOR
  2. AMPK
  3. O-304

O-304 

Cat. No.: HY-112233 Purity: 99.72%
Handling Instructions

O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a drug to treat type 2 diabetes (T2D) and associated cardiovascular complications .

For research use only. We do not sell to patients.

O-304 Chemical Structure

O-304 Chemical Structure

CAS No. : 1261289-04-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 198 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 280 In-stock
Estimated Time of Arrival: December 31
25 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 850 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a drug to treat type 2 diabetes (T2D) and associated cardiovascular complications [1][2].

IC50 & Target

AMPK[1]

In Vivo

O-304 increases glucose uptake in skeletal muscle, reduced β cell stress, and promoted β cell rest in diet-induced obese mice. O-304 reduces fasting plasma glucose levels and homeostasis model assessment of insulin resistance (HOMA-IR) in a proof-of-concept phase IIa clinical trial in type 2 diabetes (T2D) patients on Metformin[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

380.25

Formula

C₁₆H₁₁Cl₂N₃O₂S

CAS No.

1261289-04-6

SMILES

O=C(NC(SN1CC2=CC=C(Cl)C=C2)=NC1=O)C3=CC=C(Cl)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (78.90 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6298 mL 13.1492 mL 26.2985 mL
5 mM 0.5260 mL 2.6298 mL 5.2597 mL
10 mM 0.2630 mL 1.3149 mL 2.6298 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.57 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.72%

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Keywords:

O-304O304O 304AMPKAMP-activated protein kinaseInhibitorinhibitorinhibit

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Product Name:
O-304
Cat. No.:
HY-112233
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