1219739-95-3
1219739-95-3
Chemical Structure
AMPK-IN-1
- CAS No.: 1219739-95-3
- Formula:C24H18ClN3O3
- Molecular Weight:431.87
IUPAC Name: 5-((5-chloro-6-(1-methyl-1H-indol-6-yl)-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic acid
InChIKey: ZPCGOSPLONPSIC-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC(OC2=NC3=CC(Cl)=C(C4=CC5=C(C=C4)C=CN5C)C=C3N2)=CC=C1C
Biological Activity: AMPK-IN-1 is an activator of AMPK (EC50: 551 nM for isoform α2β2γ1). AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AMPK-IN-1 | 95.19% | AMPK-IN-1 is an activator of AMPK (EC50: 551 nM for isoform α2β2γ1). AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way. | ||||||||||||||||||||
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References
- [1]. Ngoei KRW, et al. Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4. Cell Chem Biol. 2018 Jun 21;25(6):728-737.e9. [Content Brief]
- [2]. Cao Y, et al. Novel cyclic benzimidazole derivatives useful anti-diabetic agents. Patent. WO2010036613.
- [3]. Johanns M, et al. Direct and indirect activation of eukaryotic elongation factor 2 kinase by AMP-activated protein kinase. Cell Signal. 2017 Aug;36:212-221. [Content Brief]
Keywords
