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AMPK-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (9) Apoptosis (1) ATP Citrate Lyase (1) Autophagy (1) Calcium Channel (1) Cannabinoid Receptor (1) Endogenous Metabolite (1) HDAC (1) β-catenin (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Metabolic Disease (6) Neurological Disease (1)

13

Inhibitors & Agonists

5

Natural
Products

1

Isotope-Labeled Compounds

Targets Recommended: AMPK AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

3α-Hydroxymogrol	AMPK	Metabolic Disease
3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle, acts as a potent *AMPK* activator, and enhances AMPK phosphorylation .

AICA-riboside, 5′-phosphate AICAR-5'-MP	Endogenous Metabolite	Others
AICA-riboside, 5′-phosphate (AICAR-5'-MP) is a 5'-phosphorylated analogue of AICAR. AICAR is an adenosine analog and a AMPK activator. .

HY-120904

AMPK-IN-1

AMPK Metabolic Disease

AMPK-IN-1 is an activator of AMPK (EC₅₀: 551 nM for isoform α2β2γ1). AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way ^[1] .

CB1R/AMPK modulator 1	AMPK Cannabinoid Receptor	Metabolic Disease
CB1R/AMPK modulator 1 (Compound 38-S) is an orally active *CB1R/AMPK* modulator, with an K_i of 0.81 nM and an IC₅₀ of 3.9 nM for CB1R. CB1R/AMPK modulator 1 activates AMPK. CB1R/AMPK modulator 1 reduces food intake and body weight, and improves glucose tolerance and insulin sensitivity ^[1].

HY-N3425

Kazinol U

AMPK Others

Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation .
HY-U00292

AMPK activator 1

AMPK Metabolic Disease

AMPK activator 1 is an AMPK activator extracted from patent WO2013116491A1, compound No.1-75, has an EC₅₀ of <0.1μM.

Etilefrine
Etilefrine (3-[2-(ethylamino)-1-hydroxyethyl]phenol) is an α adrenergic agonist . Etilefrine also is an *AMPK* activator . Etilefrine can be used for the research of postural hypotension .

Bempedoic acid-d4 ETC-1002-d₄; ESP-55016-d₄	ATP Citrate Lyase AMPK	Others
Bempedoic acid-d₄ is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK[1][2].

SEC	Apoptosis	Cancer
SEC induces activation of ANXA7 GTPase via the AMPK/mTORC1/STAT3 signaling pathway. SEC selectively promotes apoptosis in cancer cells, expressing a high level of ITGB4 by inducing ITGB4 nuclear translocation ^[1] .

YW2065	β-catenin	Cancer
YW2065 is an *Axin-1* stabilizer. Axin-1 is a scaffolding protein that regulates proteasome degradation of β-catenin. YW2065 exhibits anti-colorectal cancer effects via dual activities of wnt/β-catenin signaling inhibition and *AMPK* activation .

AMDE-1	Autophagy AMPK	Cancer
AMDE-1 is a potent autophagy inducer. AMDE-1 induces autophagy by the AMPK-mTORC1-ULK1 pathway and at the same time inhibited autophagy-mediated degradation by causing lysosome dysfunction. AMDE-1 can be used in research of cancer ^[1].

Gomisin J 3 Publications Verification	AMPK Calcium Channel	Cardiovascular Disease Metabolic Disease
Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity ^[1]. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of *AMPK, LKB1* and Ca ²⁺/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease .

Marein	AMPK HDAC	Cardiovascular Disease Neurological Disease Metabolic Disease
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC₅₀ of 100 µM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

3α-Hydroxymogrol	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Metabolic Disease Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields	AMPK
3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle, acts as a potent *AMPK* activator, and enhances AMPK phosphorylation .

AICA-riboside, 5′-phosphate AICAR-5'-MP	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
AICA-riboside, 5′-phosphate (AICAR-5'-MP) is a 5'-phosphorylated analogue of AICAR. AICAR is an adenosine analog and a AMPK activator. .

Gomisin J 3 Publications Verification	Cardiovascular Disease Monophenols Classification of Application Fields Source classification Lignans Phenols Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.	AMPK Calcium Channel
Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity ^[1]. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of *AMPK, LKB1* and Ca ²⁺/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease .

Marein	Cardiovascular Disease Flavonoids Chalcones other families Classification of Application Fields Neurological Disease Source classification Phenols Polyphenols Plants Disease Research Fields	AMPK HDAC
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC₅₀ of 100 µM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects ^[1] .

Kazinol U	Flavonoids other families Classification of Application Fields Flavanols Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	AMPK
Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK* activation .*

Cat. No.	Product Name	Chemical Structure

Bempedoic acid-d4
Bempedoic acid-d₄ is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK[1][2].

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