1. Epigenetics
    PI3K/Akt/mTOR
    Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. AMPK
    Calcium Channel
  3. Gomisin J

Gomisin J 

Cat. No.: HY-N0385 Purity: ≥99.0%
Handling Instructions

Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease.

For research use only. We do not sell to patients.

Gomisin J Chemical Structure

Gomisin J Chemical Structure

CAS No. : 66280-25-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 128 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 128 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Gomisin J

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity[1]. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease[2].

IC50 & Target

AMPK

 

Ca2+

 

Molecular Weight

388.45

Formula

C₂₂H₂₈O₆

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (257.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5743 mL 12.8717 mL 25.7433 mL
5 mM 0.5149 mL 2.5743 mL 5.1487 mL
10 mM 0.2574 mL 1.2872 mL 2.5743 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.44 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.44 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.44 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: ≥99.0%

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Product Name:
Gomisin J
Cat. No.:
HY-N0385
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