1. Epigenetics
    PI3K/Akt/mTOR
    Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. AMPK
    Calcium Channel
  3. Gomisin J

Gomisin J 

Cat. No.: HY-N0385
Handling Instructions

Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease.

For research use only. We do not sell to patients.

Gomisin J Chemical Structure

Gomisin J Chemical Structure

CAS No. : 66280-25-9

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Description

Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity[1]. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease[2].

IC50 & Target[2]

AMPK

 

Ca2+

 

Molecular Weight

388.45

Formula

C₂₂H₂₈O₆

CAS No.

66280-25-9

SMILES

OC1=C(OC)C(OC)=C(C2=C(OC)C(OC)=C(O)C=C2CC(C)C(C)C3)C3=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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