Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells

  • Bioorg Med Chem Lett. 2008 Jan 15;18(2):523-6. doi: 10.1016/j.bmcl.2007.11.082.
Hye-Young Min  1 ,  Eun-Jung Park ,  Ji-Young Hong ,  You-Jin Kang ,  Sun-Jack Kim ,  Hwa-Jin Chung ,  Eun-Rhan Woo ,  Tran Manh Hung ,  Ui Jung Youn ,  Yeong Shik Kim ,  Sam Sik Kang ,  KiHwan Bae ,  Sang Kook Lee
Affiliations
  • 1. College of Pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-ku, Seoul 120-750, Republic of Korea.
PMID: 18063366 DOI: 10.1016/j.bmcl.2007.11.082
Abstract

Dibenzocyclooctadiene Lignans isolated from Schisandra chinensis showed antiproliferative effects in various human Cancer cells. The methoxy groups at C-3, C-4, C-3', and C-4', the hydroxyl group at C-8', and the stereo-configuration of the biphenyl ring and the angeloyl group might have influence on these activities. Additional studies indicate that one of mechanism of action of an active compound schizantherin C in A549 human lung Cancer cells was related to the inhibition of cell cycle progression in G0/G1 phase.

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