1. Apoptosis
  2. Apoptosis
  3. SEC

SEC 

Cat. No.: HY-125355 Purity: 98.13%
Handling Instructions

SEC induces activation of ANXA7 GTPase via the AMPK/mTORC1/STAT3 signaling pathway. SEC selectively promotes apoptosis in cancer cells, expressing a high level of ITGB4 by inducing ITGB4 nuclear translocation.

For research use only. We do not sell to patients.

SEC Chemical Structure

SEC Chemical Structure

CAS No. : 1802997-81-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 330 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 500 In-stock
Estimated Time of Arrival: December 31
25 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1550 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

SEC induces activation of ANXA7 GTPase via the AMPK/mTORC1/STAT3 signaling pathway. SEC selectively promotes apoptosis in cancer cells, expressing a high level of ITGB4 by inducing ITGB4 nuclear translocation[1][2].

In Vitro

SEC (20 µM) inhibits the cell migration of HEK 293T RKIP−/− cells and PC3 prostate cancer cells[1].
SEC (20 µM) significantly increases AMPK phosphorylation in PC3 cells, which is inverted by ANXA7 GTPase specific inhibitor ABO, indicating that activated ANXA7 with enhanced phosphorylation level promotes AMPK phosphorylation (cell selectively)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HEK293T RKIP−/− cells.[1]
Concentration: 20 µM.
Incubation Time: 24 h.
Result: Suppressed HEK293T RKIP−/− cell migration while had no effect on HEK293T RKIP+/+ cells.
In Vivo

SEC (3 mg/kg/day or 18 mg/kg/day) suppresses metastasis in PC-3M-Luc orthotopic implantation nude mice model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Luciferase-labeled PC-3M-Luc cells (2×106 per 50 µL sterile HBSS−/−) are orthotopically inoculated into the prostates of 8-week-old nude mice[1].
Dosage: 3 mg/kg/day or 18 mg/kg/day.
Administration: IP daily for 3 weeks.
Result: Suppressed the lymph node metastatic capacities of PC-3M-Luc cells in the nude mice model.
Decreased the mRNA level of CCL2, APLN and IL6ST in implanted tumors.
Did not affect the body weight of the mice.
Clinical Trial
Molecular Weight

430.88

Formula

C₂₂H₂₃ClN₂O₅

CAS No.

1802997-81-4

SMILES

O=C(OCC)C1=CC(C2=CC=C(C=C2)OC)=NN1C[[email protected]@H](COC3=CC=C(C=C3)Cl)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (232.08 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3208 mL 11.6042 mL 23.2083 mL
5 mM 0.4642 mL 2.3208 mL 4.6417 mL
10 mM 0.2321 mL 1.1604 mL 2.3208 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.80 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (5.80 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.80 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SECApoptosisANXA7GTPaseAMPKmTORC1STAT3PC3prostatecancerITGB4metastasissafeInhibitorinhibitorinhibit

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SEC
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HY-125355
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