AMPK activator 8
AMPK activator 8 (compound 2) is an AMP-activated protein kinase (AMPK) activator with EC50s of 11, 27, 4, 2, and 4 nM for rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ1, rAMPK α2β2γ3, respectively. AMPK activator 8 can be used for the research of type 2 diabetes.
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- CAS No.: 1852451-96-7
- Formule: C25H21ClN2O6
- Masse moléculaire:480.90
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Activité biologique
Description
IC50 & Target
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AMPK α1β1γ1 11 nM (EC50) |
AMPK α2β1γ1 27 nM (EC50) |
AMPK α1β2γ1 4 nM (EC50) |
AMPK α2β2γ1 2 nM (EC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COS-7 | EC50 |
11 nM
Compound: 28
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Activation of human recombinant AMPK alpha1/beta1/gamma1 expressed in African green monkey COS7 cells assessed as increase in biotinylated AAC (1 to 120 residues) peptide phosphorylation at Ser-79 residue measured after 60 mins by Alphascreen assay
Activation of human recombinant AMPK alpha1/beta1/gamma1 expressed in African green monkey COS7 cells assessed as increase in biotinylated AAC (1 to 120 residues) peptide phosphorylation at Ser-79 residue measured after 60 mins by Alphascreen assay
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[PMID: 27727125] |
| COS-7 | EC50 |
2 nM
Compound: 28
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Activation of human recombinant AMPK alpha2/beta2/gamma1 expressed in African green monkey COS7 cells assessed as increase in biotinylated AAC (1 to 120 residues) peptide phosphorylation at Ser-79 residue measured after 60 mins by Alphascreen assay
Activation of human recombinant AMPK alpha2/beta2/gamma1 expressed in African green monkey COS7 cells assessed as increase in biotinylated AAC (1 to 120 residues) peptide phosphorylation at Ser-79 residue measured after 60 mins by Alphascreen assay
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[PMID: 27727125] |
| COS-7 | EC50 |
27 nM
Compound: 28
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Activation of human recombinant AMPK alpha2/beta1/gamma1 expressed in African green monkey COS7 cells assessed as increase in biotinylated AAC (1 to 120 residues) peptide phosphorylation at Ser-79 residue measured after 60 mins by Alphascreen assay
Activation of human recombinant AMPK alpha2/beta1/gamma1 expressed in African green monkey COS7 cells assessed as increase in biotinylated AAC (1 to 120 residues) peptide phosphorylation at Ser-79 residue measured after 60 mins by Alphascreen assay
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[PMID: 27727125] |
| COS-7 | EC50 |
4 nM
Compound: 28
|
Activation of human recombinant AMPK alpha1/beta2/gamma1 expressed in African green monkey COS7 cells assessed as increase in biotinylated AAC (1 to 120 residues) peptide phosphorylation at Ser-79 residue measured after 60 mins by Alphascreen assay
Activation of human recombinant AMPK alpha1/beta2/gamma1 expressed in African green monkey COS7 cells assessed as increase in biotinylated AAC (1 to 120 residues) peptide phosphorylation at Ser-79 residue measured after 60 mins by Alphascreen assay
|
[PMID: 27727125] |
| COS-7 | EC50 |
4 nM
Compound: 28
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Activation of human recombinant AMPK alpha2/beta2/gamma3 expressed in African green monkey COS7 cells assessed as increase in biotinylated AAC (1 to 120 residues) peptide phosphorylation at Ser-79 residue measured after 60 mins by Alphascreen assay
Activation of human recombinant AMPK alpha2/beta2/gamma3 expressed in African green monkey COS7 cells assessed as increase in biotinylated AAC (1 to 120 residues) peptide phosphorylation at Ser-79 residue measured after 60 mins by Alphascreen assay
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[PMID: 27727125] |
In Vitro
AMPK activator 8 (compound 2) acts on rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ and rAMPK α2β2γ3 with the EC50 value of 11 nM, 27 nM, 4 nM, 2 nM and 4 nM, respectively[1]. AMPK activator 8 (compound 2) affects cell viability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2, C2C12 myoblasts
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Concentration:0.01-1000 μM
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Incubation Time:1 hour
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Result:Resulted in HepG2 and C2C12 myoblasts with the EC50 value of 255 nM and 230 nM, respectively.
Chemical Information
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CAS No. 1852451-96-7
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Masse moléculaire 480.90
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Formule C25H21ClN2O6
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SMILES
ClC1=C(C2=CC=C(C3=C(C=CC=C3O)O)C=C2)C=C4NC(O[C@H]5[C@]6([H])[C@]([C@@H](CO6)O)([H])OC5)=NC4=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AMPK activator 8 Related Classifications
HY-147038 Related Classifications
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