Pyrrolidine linoleamide
Pyrrolidine linoleamide is a derivative of linoleic acid amide with anticancer activity. Pyrrolidine linoleamide exhibits antiproliferative activity against a range of cancer cell lines, with IC50 values of 12.0, 27.5, 7.7, 21.9, 36.6, 32.6, and 33.9 μg/mL against U251, MCF-7, NCI-ADR/RES, 786-0, NCI-H460, PC-3, and OVCAR-3 cell lines, respectively.
For research use only. We do not sell to patients.
- CAS No.: 3140-51-0
- Formula: C22H39NO
- Molecular Weight:333.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 786-0 | GI50 |
4.7 μg/mL
Compound: 5e
|
Antiproliferative activity against human 786-0 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human 786-0 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 25510639] |
| MCF7 | GI50 |
4.2 μg/mL
Compound: 5e
|
Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 25510639] |
| NCI/ADR-RES | GI50 |
4.7 μg/mL
Compound: 5e
|
Antiproliferative activity against human NCI/ADR-RES cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human NCI/ADR-RES cells after 48 hrs by sulforhodamine B assay
|
[PMID: 25510639] |
| NCI-H460 | GI50 |
7 μg/mL
Compound: 5e
|
Antiproliferative activity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 25510639] |
| OVCAR-3 | GI50 |
5.7 μg/mL
Compound: 5e
|
Antiproliferative activity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 25510639] |
| PC-3 | GI50 |
4.7 μg/mL
Compound: 5e
|
Antiproliferative activity against human PC3 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human PC3 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 25510639] |
| U-251 | GI50 |
4.2 μg/mL
Compound: 5e
|
Antiproliferative activity against human U251 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human U251 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 25510639] |
Chemical Information
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CAS No. 3140-51-0
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Molecular Weight 333.55
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Formula C22H39NO
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SMILES
CCCCC/C=C\C/C=C\CCCCCCCC(N1CCCC1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)