2. Signaling Pathways
  3. Apoptosis
  4. Caspase
  5. Caspase 11 Isoform

Caspase 11

Caspase-11 is a murine inflammatory caspase that drives the noncanonical inflammasome response to cytosolic lipopolysaccharide (LPS) from Gram-negative bacteria[1][2]. Mechanistically, activated caspase-11 cleaves gasdermin D (GSDMD), producing an N-terminal fragment that promotes pyroptosis, IL-1β maturation, and lethal LPS responses[1]. In intestinal epithelial defense, caspase-11 deficiency increases Salmonella Typhimurium epithelial colonization, while human caspase-4 depletion similarly increases bacterial colonization in polarized epithelial monolayers[3]. In kidney injury models, caspase-11/GSDMD signaling promotes tubular epithelial pyroptosis, urinary IL-18 excretion, renal functional deterioration, and podocyte injury under diabetic or acute injury conditions[4][5]. Compared with canonical inflammasomes that activate caspase-1 through NLR or PYHIN sensors, caspase-11 and human caspase-4/5 act as noncanonical intracellular LPS sensors[2][6]. For experimental applications, cardiolipin selectively blocks caspase-4/11-dependent cell death by preventing LPS binding, while maclurin suppresses caspase-11 and GSDMD activation in macrophages and improves acute lethal sepsis outcomes in mice[7][8].

References:

Caspase 11 Related Products (2):

Cat. No. Product Name Effect Purity
  • HY-N0551
    Wedelolactone
    		Inhibitor 99.93%
    Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC50 of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer.
  • HY-111675
    Ac-FLTD-CMK
    		Inhibitor 99.18%
    Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3.