2376255-48-8
Chemical Structure
Ac-FLTD-CMK
- CAS No.: 2376255-48-8
- Formula:C26H37ClN4O8
- Molecular Weight:569.05
IUPAC Name: (4S,7S,10S,13S)-4-benzyl-13-(2-chloroacetyl)-10-((R)-1-hydroxyethyl)-7-isobutyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid
InChIKey: UCWNTWGHVCSMJP-WPUDHWPRSA-N
SMILES: ClCC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CC(C)C)NC([C@@H](NC(C)=O)CC1=CC=CC=C1)=O)=O)=O)=O
Biological Activity: Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ac-FLTD-CMK | 99.18% | Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3. | ||||||||||||||||||||
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