1. Apoptosis
    Immunology/Inflammation
  2. Caspase
    Pyroptosis
  3. Ac-FLTD-CMK

Ac-FLTD-CMK 

Cat. No.: HY-111675 Purity: 99.53%
Handling Instructions

Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is potent against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3.

For research use only. We do not sell to patients.

Ac-FLTD-CMK Chemical Structure

Ac-FLTD-CMK Chemical Structure

CAS No. : 2376255-48-8

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is potent against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3[1].

IC50 & Target[1]

Caspase-1

46.7 nM (IC50)

Caspase-4

1.49 μM (IC50)

Caspase-5

329 nM (IC50)

Caspase-11

 

In Vitro

Ac-FLTD-CMK, inhibits GSDMD cleavage by caspases-1, -4, -5, and -11 in vitro, suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages. By contrast, Ac-FLTD-CMK does not target caspase-3 or apoptotic cell death. Crystal structure of caspase-1 in complex with Ac-FLTD-CMK reveals extensive enzyme-inhibitor interactions involving both hydrogen bonds and hydrophobic contacts[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

569.05

Formula

C₂₆H₃₇ClN₄O₈

CAS No.

2376255-48-8

SMILES

ClCC([[email protected]](CC(O)=O)NC([[email protected]]([[email protected]](O)C)NC([[email protected]](CC(C)C)NC([[email protected]@H](NC(C)=O)CC1=CC=CC=C1)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

References
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Keywords:

Ac-FLTD-CMKCaspasePyroptosisGSDMDinflammatorycaspases-1caspases-4caspases-5caspases-11IL-1βNLRP3Inhibitorinhibitorinhibit

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Ac-FLTD-CMK
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