Search Result
Results for "
inflammatory
" in MCE Product Catalog:
2313
Inhibitors & Agonists
11
Biochemical Assay Reagents
207
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
-
- HY-146421
-
|
Anti-inflammatory agent 21
|
NO Synthase
NF-κB
Reactive Oxygen Species
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 21 (compound 9o) is an orally active and low cytotoxic anti-inflammatory agent, with an IC50 value of 0.76 μM for NO. Anti-inflammatory agent 21 acts via accumulation ROS and blocks the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 21 can ameliorate cartilage destruction and inflammatory cell infiltration in arthritis rats model.
|
-
- HY-146547
-
|
Anti-inflammatory agent 17
|
TNF Receptor
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 17 is a potent and orally active anti-inflammatory agent. Anti-inflammatory agent 17 inhibits the release of IL-6 and TNF-α in vitro experiments without cytotoxicity. Anti-inflammatory agent 17 exhibits anti-inflammatory activity in vivo. Anti-inflammatory agent 17 has the potential for the research of Acute lung injury (ALI).
|
-
- HY-148553
-
-
- HY-147769
-
|
Anti-inflammatory agent 23
|
Others
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 23 (Compound 4m) is an anti-inflammatory agent. Anti-inflammatory agent 23 inhibits the production of NO activated by LPS with an IC50 of 0.449 μM. Anti-inflammatory agent 23 has a good affinity for p65 protein.
|
-
- HY-148552
-
|
Anti-inflammatory agent 35
|
p38 MAPK
ERK
NF-κB
Interleukin Related
TNF Receptor
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 35 (compound 5a27) is an orally active curcumin analogue with anti-inflammatory activity. Anti-inflammatory agent 35 blocks mitogen-activated protein kinase (MAPK) signaling and p65 nuclear translocation of NF-kB. Anti-inflammatory agent 35 also inhibits yellow neutrophil infiltration and pro-inflammatory cytokine production. Anti-inflammatory agent 35 significantly attenuates lipopolysaccharide (LPS)-induced acute lung injury (ALI) in vivo.
|
-
- HY-146435
-
|
Anti-inflammatory agent 22
|
TNF Receptor
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 22 (compound 14a) is an orally active anti-inflammatory agent. Anti-inflammatory agent 22 inhibits LPS-induced TNF-α production with an IC50 value of 14.6 μM. Anti-inflammatory agent 22 has preventive effects on lymphedematous tissue via suppression of adipogenesis. Anti-inflammatory agent 22 suppresses limb lymphedema volume in mice.
|
-
- HY-151921
-
|
Anti-inflammatory agent 33
|
p38 MAPK
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 33 is a potent p38α inhibitor. Anti-inflammatory agent 33 inhibits NO production. Anti-inflammatory agent 33 inhibits LPS-induced iNOS, COX-2, p-p38α, p-MK2 protein expression. Anti-inflammatory agent 33 shows anti-inflammatory activity.
|
-
- HY-145869
-
|
Anti-inflammatory agent 12
|
Others
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 12 (Compound 2) is a pentacyclic triterpene compound. Anti-inflammatory agent 12 shows a significant bias in the LPS-induced inflammatory response with an IIC50 value of 2.22 μM. Anti-inflammatory agent 12 has the potential for the research of inflammation disease.
|
-
- HY-N10436
-
-
- HY-N10435
-
-
- HY-N10434
-
-
- HY-150156
-
-
- HY-143410
-
-
- HY-148456
-
-
- HY-U00273
-
-
- HY-146419
-
|
Anti-inflammatory agent 20
|
NF-κB
COX
TNF Receptor
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 20 (compound 5a) is a potent inhibitor of NO activity. Anti-inflammatory agent 20 shows anti-inflammatory activity. Anti-inflammatory agent 20 suppresses LPS-induced inflammation via inhibiting the activation of NF-κB and MAPK signaling and thereby reducing IL-6, TNF-α, iNOS, and COX-2 upregulation.
|
-
- HY-153579
-
-
- HY-145870
-
|
Anti-inflammatory agent 13
|
Others
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 13 (Compound 3) is a pentacyclic triterpene compound. Anti-inflammatory agent 13 exhibits a considerable inhibitory effect on inflammation models. Anti-inflammatory agent 13 has the potential for the research of either DAMPs or PAMPs triggered inflammation.
|
-
- HY-115922
-
|
Anti-inflammatory agent 10
|
COX
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 10 (compound 30) is a tilomisole-based benzimidazothiazole derivative. Anti-inflammatory agent 10 expresses activity on COX-2 enzyme more than COX-1. Anti-inflammatory agent 10 is orally active.
|
-
- HY-115921
-
|
Anti-inflammatory agent 9
|
COX
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 9 (compound 28) is a tilomisole-based benzimidazothiazole derivative. Anti-inflammatory agent 9 expresses activity on COX-2 enzyme more than COX-1. Anti-inflammatory agent 9 is orally active.
|
-
- HY-144737
-
|
Anti-inflammatory agent 15
|
Bacterial
TNF Receptor
|
Infection
Inflammation/Immunology
|
|
Anti-inflammatory agent 15 (compound 29) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 15 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 2.3 and 7.8 μM, respectively. Anti-inflammatory agent 15 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 15 can be used for tuberculosis (TB) research.
|
-
- HY-144727
-
|
Anti-inflammatory agent 11
|
Bacterial
TNF Receptor
|
Infection
Inflammation/Immunology
|
|
Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research.
|
-
- HY-150587
-
|
Anti-inflammatory agent 31
|
ERK
NF-κB
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 31 (enone 17) is a kind of andrographolide derivatives, is a anti-inflammatory agent. Anti-inflammatory agent 31 inhibits NF-κB activation by upstream blockade of PI3K/Akt and ERK1/2 MAPK activation. Anti-inflammatory agent 31 shows recovery effective of the intracellular GSH levels and protective effect on liver.
|
-
- HY-115920
-
|
Anti-inflammatory agent 8
|
COX
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 8 (compound 13) is a tilomisole-based benzimidazothiazole derivative. Anti-inflammatory agent 8 expresses activity on COX-2 enzyme more than COX-1 with an IC50 of 0.09 nM. Anti-inflammatory agent 8 is orally active.
|
-
- HY-144735
-
-
- HY-143457
-
|
Anti-inflammatory agent 19
|
Others
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 19 (compound 2b) shows NO inhibitory activity, with an IC50 of 36.00 μM. Anti-inflammatory agent 19 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 19 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc.
|
-
- HY-143456
-
|
Anti-inflammatory agent 18
|
Others
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 18 (compound 3b) shows NO inhibitory activity, with an IC50 of 15.94 μM. Anti-inflammatory agent 18 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 18 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc.
|
-
- HY-139833
-
-
- HY-N10066
-
-
- HY-146971
-
-
- HY-139844
-
-
- HY-N0976
-
|
1,11b-Dihydro-11b-hydroxymedicarpin
11b-Hydroxy-11b,1-dihydromedicarpin
|
Interleukin Related
|
Inflammation/Immunology
|
|
1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice.
|
-
- HY-146220
-
-
- HY-N8241
-
-
- HY-18541
-
-
- HY-132882
-
|
ARN19689
|
Others
|
Inflammation/Immunology
|
|
ARN19689 is a potent, selective, orally active and non-covalent inhibitor of N‑Acylethanolamine-Hydrolyzing Acid Amidase (NAAA), with an IC50 of 42 nM. ARN19689 is a promising pharmacological tool to be further investigated in the field of inflammatory conditions.
|
-
- HY-N3408
-
|
Lamiide
|
Others
|
Inflammation/Immunology
|
|
Lamiide, an orally active iridoid compound, can be found in Bouchea fluminensis leaves. Lamiide exhibits anti-inflammatory and anti-lipoperoxidative activity.
|
-
- HY-12909
-
-
- HY-138501
-
-
- HY-147527
-
|
CDK8-IN-5
|
CDK
|
Inflammation/Immunology
|
|
CDK8-IN-5 is a potent CDK8 inhibitor with an IC50 of 72 nM. CDK8-IN-5 shows anti-inflammatory activities with 43% IL-10 enhancement rate. CDK8-IN-5 has the potential for the research of inflammatory bowel disease.
|
-
- HY-137245
-
-
- HY-137245A
-
-
- HY-N2905
-
|
Aurantiamide acetate
Asperglaucide
|
Cathepsin
|
Inflammation/Immunology
|
|
Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases.
|
-
- HY-P1717B
-
|
AMY-101 acetate
Cp40 acetate
|
Complement System
SARS-CoV
|
Inflammation/Immunology
|
|
AMY-101 acetate (Cp40 acetate), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 acetate (Cp40 acetate) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation.
|
-
- HY-P1717A
-
|
AMY-101 TFA
Cp40 TFA
|
Complement System
SARS-CoV
|
Inflammation/Immunology
|
|
AMY-101 TFA (Cp40 TFA), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation.
|
-
- HY-W013812
-
|
Ethyl linoleate
Linoleic Acid ethyl ester; Mandenol
|
Others
|
Cardiovascular Disease
|
Ethyl linoleate (Linoleic Acid ethyl ester) inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators.
|
-
- HY-P99520
-
|
Vilobelimab
CaCP-29, IFX-1
|
Complement System
SARS-CoV
|
Infection
Inflammation/Immunology
|
|
Vilobelimab (CaCP-29, IFX-1) is a monoclonal anti-C5a antibody to the allergen C5a, a pro-inflammatory complement division product that plays a central role in mediating organ dysfunction. Vilobelimab acts as a C5a inhibitor, inhibiting neutrophil activation, chemotaxis, and reducing inflammatory signalling, and may be used in studies related to sepsis, COVID-19, etc.
|
-
- HY-102075B
-
|
TMP780
|
ROR
|
Inflammation/Immunology
|
|
TMP780 is an inverse agonist of RORγt with an IC50 of 13 nM. RORγt is a tractable agent target for the treatment of cutaneous inflammatory disorders.
|
-
- HY-110292
-
-
- HY-143480
-
-
- HY-N0268
-
|
Irisflorentin
|
NO Synthase
|
Inflammation/Immunology
|
|
Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity.
|
-
- HY-137789
-
|
Tazofelone
LY 213829
|
COX
|
Cancer
|
|
Tazofelone (LY 213829) is a cyclooxygenase-II (COX-II) inhibitor. Tazofelone transform into sulfoxide and quinol metabolites is primarily mediated by CYP3A. Tazofelone can be used for the research of inflammatory bowel disease.
|
-
- HY-32135
-
-
- HY-B1365
-
-
- HY-N10317
-
-
- HY-16640
-
|
TCJL37
|
JAK
|
Inflammation/Immunology
|
|
TCJL37 is a potent, selective, and orally bioavailable TYK2 inhibitor with a Ki of 1.6 nM. TCJL37 can be used for the research of inflammatory bowel diseases (IBD).
|
-
- HY-111570
-
|
AZ2
|
PI3K
|
Inflammation/Immunology
|
|
AZ2 is a highly selective PI3Kγ inhibitor (The pIC50 value for PI3Kγ is 9.3). AZ2 can be used for the research of inflammatory and immune diseases.
|
-
- HY-105484
-
-
- HY-149282
-
-
- HY-149281
-
-
- HY-W281862
-
-
- HY-132269
-
|
Isoflupredone
|
Others
|
Inflammation/Immunology
|
|
Isoflupredone belongs to the class of corticosteroids and exerts its effect by binding to glucocorticoid and mineralocorticoid receptors of animals, such as horses. Isoflupredone can be used in wide range of conditions, such as infection and inflammatory diseases.
|
-
- HY-P3648
-
-
- HY-N2258
-
|
Poncirin
|
Apoptosis
|
Inflammation/Immunology
|
|
Poncirin is isolated from Poncirus trifoliata with anti-inflammory activites. Poncirin significantly reduces mechanical hyperalgesia and allodynia in Complete Freund’s Adjuvant (CFA)-induced inflammatory pain models.
|
-
- HY-103344
-
|
ZJ43
|
Aminopeptidase
mGluR
|
Inflammation/Immunology
Neurological Disease
|
|
ZJ43 is a potent NAAG peptidase inhibitor, with an IC50 of 2.4 nM and a Ki of 0.8 nM. ZJ43 sufficiently activates group II mGluR and reduces some of the behavioral effects of PCP. ZJ43 shows an analgesic effect in neuropathic and inflammatory and pain models.
|
-
- HY-108644
-
-
- HY-N3007
-
|
Naringenin chalcone
|
Others
|
Inflammation/Immunology
|
|
Naringenin chalcone is an intermediate in flavonol biosynthesis and is spontaneously metabolized into naringenin (NAR) by chalcone isomerase. Naringenin chalcone has anti-inflammatory and antiallergic activities.
|
-
- HY-148531
-
|
PF-07054894
|
CCR
|
Inflammation/Immunology
|
|
PF-07054894 is a potent CCR6 antagonist. PF-07054894 targets G protein-coupled receptor (GPCR). PF-07054894 can be used in research of inflammatory bowel disease.
|
-
- HY-137881
-
-
- HY-139557
-
|
Zastaprazan
JP-1366
|
Proton Pump
|
Inflammation/Immunology
|
|
Zastaprazan (JP-1366) is a proton pump inhibitor (WO2018008929). Zastaprazan can be used for the research of gastrointestinal inflammatory diseases or gastric acid-related diseases.
|
-
- HY-150215
-
-
- HY-150216
-
-
- HY-142940
-
|
RORγt modulator 5
|
ROR
|
Inflammation/Immunology
|
|
RORγt modulator 5 is a RORγt modulator with a Ki value of <100 nM. RORγt modulator 5 has the potential for inflammatory, metabolic, autoimmune and other diseases mediated by RORy study (WO2017132432A1; compound 2).
|
-
- HY-103018
-
|
Gusacitinib
ASN-002
|
JAK
Syk
|
Cancer
Inflammation/Immunology
|
|
Gusacitinib (ASN-002) is an orally active dual SYK/JAK kinase inhibitor with IC50 values of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively. Gusacitinib rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma.
|
-
- HY-N3323
-
-
- HY-153279
-
-
- HY-N8658
-
-
- HY-17480
-
|
Bendazac
|
Others
|
Inflammation/Immunology
|
|
Bendazac is an oxyacetic acid with anti-inflammatory, antinecrotic, choleretic and antilipidaemic properties. Bendazac acts by preventing protein denaturation and delays the cataractogenic process.
|
-
- HY-N2555
-
-
- HY-P3612
-
|
CTCE-0214
|
CXCR
|
Inflammation/Immunology
|
|
CTCE-0214 is a chemokine CXC receptor 4 (CXCR4) agonist, SDF-1α (stromal cell-derived factor-1α) peptide analog. CTCE-0214 shows anti-inflammatory activity, and can be used in inflammation sepsis and systemic inflammatory syndromes research.
|
-
- HY-12358
-
-
- HY-142843
-
-
- HY-120441
-
-
- HY-108966
-
|
Kushenol C
|
Beta-secretase
|
Inflammation/Immunology
|
|
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC50 of 5.45 µM.
|
-
- HY-149102
-
-
- HY-P1717
-
|
AMY-101
Cp40
|
Complement System
SARS-CoV
|
Inflammation/Immunology
|
|
AMY-101 (Cp40), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation.
|
-
- HY-108346
-
|
JX401
|
p38 MAPK
|
Inflammation/Immunology
|
|
JX401 is a potent inhibitor of p38alpha, containing a 4-benzylpiperidine motif. p38alpha is hyperactive in inflammatory diseases, and various indications suggest that its inhibition would reverse inflammation. JX401 has the potential for the research of inflammation.
|
-
- HY-136741
-
|
BOT-64
|
IKK
|
Inflammation/Immunology
|
|
BOT-64 is an inhibitory κB (IκB) kinase β (IKKβ) inhibitor with an IC50 of 1 µM. BOT-64 blocks lipopolysaccharide-induced nuclear factor-κB activation and nuclear factor-κB-regulated inflammatory gene transcription.
|
-
- HY-N2597
-
-
- HY-117714
-
-
- HY-112763
-
|
CLinDMA
|
Liposome
|
Inflammation/Immunology
|
|
CLinDMA, a cationic lipid, can cause inflammatory response. CLinDMA can be used for the synthesis LNP201. LNP201 is a liposome assembly for systemic delivery of siRNA.
|
-
- HY-P3499
-
|
Dolcanatide
|
Guanylate Cyclase
|
Inflammation/Immunology
|
|
Dolcanatide is an orally active GC-C (guanylate cyclase-C) agonist. Dolcanatide shows laxative, anti-nociceptive and anti-inflammatory activity. Dolcanatide can be used in inflammatory bowel disease research.
|
-
- HY-147235
-
|
RIPK2-IN-2
|
RIP kinase
PROTACs
|
Infection
|
|
RIPK2-IN-2 (example 25) is a RIP2 kinase PROTAC inhibitor. RIPK2-IN-2 can block RIP2-dependent proinflammatory signaling, regulated RIP2 kinase activity in auto inflammatory diseases.
|
-
- HY-N9451
-
-
- HY-133907
-
-
- HY-121467
-
|
Acotiamide
Z-338 free base; YM443 free base
|
Cholinesterase (ChE)
|
Metabolic Disease
Inflammation/Immunology
|
|
Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.
|
-
- HY-121467A
-
|
Acotiamide hydrochloride
Z-338; YM443
|
Cholinesterase (ChE)
|
Metabolic Disease
Inflammation/Immunology
Others
|
|
Acotiamide hydrochloride is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide hydrochloride can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide hydrochloride has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.
|
-
- HY-N8487
-
|
7-Methoxyflavone
|
Others
|
Inflammation/Immunology
Neurological Disease
|
|
7-Methoxyflavone is a compound isolated from Zornia brasiliensis. 7-Methoxyflavone has peripheral antinociceptive activity. 7-Methoxyflavone inhibits paw-licking time in the neurogenic phase of the formalin pain response (65.6%) and did not decrease the nociceptive response in the inflammatory phase.
|
-
- HY-132133
-
-
- HY-A0213
-
|
Tiludronate
Tiludronic acid
|
Proton Pump
|
Inflammation/Immunology
|
|
Tiludronate (Tiludronic Acid), an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties.
|
-
- HY-P99244
-
-
- HY-A0221
-
|
Ridogrel
R 68070
|
Prostaglandin Receptor
|
Inflammation/Immunology
|
|
Ridogrel (R 68070) is an orally active combined thromboxane A2 synthetase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor blocker. Ridogrel is potent antiplatelet agent. Anti-inflammatory activities.
|
-
- HY-A0213A
-
|
Tiludronate disodium
Tiludronic acid disodium
|
Proton Pump
|
Inflammation/Immunology
|
|
Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties.
|
-
- HY-103165
-
|
PSB-0788
|
Adenosine Receptor
|
Cancer
Infection
|
|
PSB-0788 is a new selective high-affinity A2B antagonist with IC50 value of 3.64 nM and Ki value of 0.393 nM, respeactively. PSB-0788 can be used for the research for chronic inflammatory lung diseases.
|
-
- HY-136979
-
|
RBN012759
|
PARP
|
Cancer
Inflammation/Immunology
|
|
RBN012759 is a potent, selective and orally active inhibitor of PARP14, with an IC50 of <3 nM. RBN012759 displays 300-fold selectivity over the monoPARPs and 1000-fold selectivity over the polyPARPs. RBN012759 decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants.
|
-
- HY-142699
-
|
SSTR4 agonist 2
|
Somatostatin Receptor
|
Inflammation/Immunology
|
|
SSTR4 agonist 2 is a potent agonist of somatostatin receptor subtype 4 (SSTR4). SSTR4 pathway inhibits nociceptive and inflammatory processes. SSTR4 agonist 2 has the potential for the research of medical disorders related to SSTR4 (extracted from patent WO2014184275A1, compound 107).
|
-
- HY-150232
-
|
MALT1-IN-11
|
MALT1
|
Cancer
Inflammation/Immunology
|
|
MALT1-IN-11 (Example 151 in reference Patent) is a MALT1 protease inhibitor (IC50 < 10 nM). MALT1-IN-11 inhibits IL10 secretion with an IC50 of 10-100 nM. MALT1-IN-11 can be used for the research of cancer, autoimmune and inflammatory disorders.
|
-
- HY-120438
-
|
TASP0415914
|
PI3K
Akt
|
Inflammation/Immunology
|
|
TASP0415914 is a potent and orally active PI3Kγ inhibitor with an IC50 of 29 nM. TASP0415914 also shows potent Akt inhibitory activities with an IC50 of 294 nM. TASP0415914 can be used for inflammatory diseases research.
|
-
- HY-A0213B
-
|
Tiludronate disodium hemihydrate
Tiludronic acid disodium hemihydrate
|
Proton Pump
|
Metabolic Disease
|
|
Tiludronate (Tiludronic Acid) disodium hemihydrate, an orally active bisphosphonate, can act an osteoregulator. Tiludronate disodium hemihydrate is used for the research of the metabolic bone disorders. Tiludronate disodium hemihydrate is a potent inhibitor of the osteoclast vacuolar H +-ATPase. Antiresorptive and anti-inflammatory properties.
|
-
- HY-115770
-
-
- HY-145640
-
|
Vimnerixin
AZD4721; RIST4721
|
CXCR
|
Inflammation/Immunology
|
|
Vimnerixin (AZD4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2). Vimnerixin has the potential for the research of inflammatory disease.
|
-
- HY-145010
-
|
SN-011
|
STING
|
Inflammation/Immunology
|
|
SN-011 is a potent and selective mouse and human STING inhibitor, with an IC50 of 76 nM for STING signaling. SN-011 competes with cyclic dinucleotide (CDN) for the binding pocket of the STING dimer, blocking CDN binding and STING activation. SN-011 can be used for the research of STING-driven autoimmune and inflammatory disease.
|
-
- HY-111366
-
|
CD12681
|
ROR
|
Inflammation/Immunology
|
|
CD12681 (compound 14) is a potent and selective RORγ inverse agonist with IC50 of 19 nM and 10 nM for RORγ GAL4 and CD4-IL-17 cells, respectively. CD12681 decreases the IL-17 inflammatory cell recruitment. CD12681 has the potential for the research of psoriasis.
|
-
- HY-151952
-
|
NLRP3-IN-12
|
NOD-like Receptor (NLR)
|
Inflammation/Immunology
|
|
NLRP3-IN-12 is a specific NLRP3 inflammasome inhibitor. NLRP3-IN-12 reduces the release of IL-1β by targeting the NLRP3 protein, with an IC50 of 0.45 μM. NLRP3-IN-12 can be used for the research of inflammatory bowel disease.
|
-
- HY-149006
-
|
CK156
|
DAPK
|
Inflammation/Immunology
Cancer
|
|
CK156 is a highly selective death-associated protein kinase (DAPK) inhibitor with IC50s of 182 nM,34 μM, and 39 μM in the DRAK1 NanoBRET assay for DRAK1, CK2a1, and CK2a2, respectively. CK156 can be used for the research of autoimmune and inflammatory diseases.
|
-
- HY-142834
-
-
- HY-B0712B
-
|
Ceftriaxone sodium salt
Disodium ceftriaxone
|
Bacterial
Antibiotic
|
Infection
Cancer
|
|
Ceftriaxone sodium salt (Disodium ceftriaxone) is a third-generation cephalosporin antibiotic with excellent activity against many gram-negative, and reasonable activity against most gram-positive microorganisms. Anti-inflammatory and antioxidant characteristics.
|
-
- HY-145307
-
|
DATPT
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
DATPT is a 12WLVSKF17 peptide-mimetic molecule. DATPT blocks the SNX9-p47phox interaction in the endosome and suppresses reactive oxygen species and inflammatory cytokine production. DATPT with anti-inflammatory and antibacterial functions has the potential for the research of sepsis.
|
-
- HY-151188
-
|
DHU-Se1
|
NO Synthase
TNF Receptor
|
Inflammation/Immunology
|
|
DHU-Se1 is a potent anti-inflammatory agent. DHU-Se1 can stimulate macrophages to release the reactive selenium compound and reduce the expression of cellular inflammatory factors (eg: iNOS and TNF-α). DHU-Se1 alleviate the process of inflammation by blocking the polarization of macrophages from M0 to M1.
|
-
- HY-B0712A
-
|
Ceftriaxone sodium hydrate
Ceftriaxone disodium hemiheptahydrate
|
Bacterial
Antibiotic
|
Infection
Cancer
|
|
Ceftriaxone sodium hydrate (Ceftriaxone disodium hemiheptahydrate) is a third-generation cephalosporin antibiotic with excellent activity against many gram-negative, and reasonable activity against most gram-positive microorganisms. Anti-inflammatory and antioxidant characteristics.
|
-
- HY-118795
-
|
SC-22716
|
Aminopeptidase
|
Inflammation/Immunology
|
|
SC-22716 is a potent, competitive, reversible inhibitor of human LTA4 hydrolase, with an IC50 of 0.20 µM. SC-22716 has potential for the research of inflammatory bowel disease (IBD) and psoriasis.
|
-
- HY-137976
-
|
Penehyclidine hydrochloride
Penequinine hydrochloride
|
mAChR
NF-κB
|
Inflammation/Immunology
|
|
Penehyclidine (Penequinine) hydrochloride, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine hydrochloride activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine hydrochloride can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation.
|
-
- HY-142119
-
|
Penehyclidine
|
mAChR
NF-κB
|
Inflammation/Immunology
|
|
Penehyclidine, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation.
|
-
- HY-108342
-
|
PF-00956980
|
JAK
|
Inflammation/Immunology
|
|
PF-00956980 is a reversible pan-JAK inhibitor with IC50 values of 2.2, 23.1 and 59.9 μM for JAK1, JAK2 and JAK3, respectively. PF-00956980 can be used in the research of lung and skin inflammatory diseases.
|
-
- HY-N6624
-
|
Skullcapflavone II
|
Bacterial
|
Inflammation/Immunology
|
|
Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG.
|
-
- HY-147585
-
|
C5aR-IN-1
|
Complement System
|
Inflammation/Immunology
|
|
C5aR-IN-1 is a potent inhibitor of C5aR. Increased level of C5a has been associated with disorders such as autoimmune disorders and inflammatory disorders. C5aR-IN-1 has the potential for the research of inflammation diseases (extracted from patent WO2022028586A1, compound 47).
|
-
- HY-147587
-
|
C5aR-IN-3
|
Complement System
|
Inflammation/Immunology
|
|
C5aR-IN-3 is a potent inhibitor of C5aR. Increased level of C5a has been associated with disorders such as autoimmune disorders and inflammatory disorders. C5aR-IN-3 has the potential for the research of inflammation diseases (extracted from patent WO2022028586A1, compound 89).
|
-
- HY-14904A
-
|
Umifenovir hydrochloride
|
Influenza Virus
SARS-CoV
|
Infection
|
|
Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells. Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity.
|
-
- HY-77048
-
|
IRAK-4 protein kinase inhibitor 2
|
IRAK
|
Inflammation/Immunology
|
|
IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC50 of 4 μM. IRAK-4 protein kinase inhibitor 2 can be used for the research of inflammatory and immune-related conditions or disorders.
|
-
- HY-147586
-
|
C5aR-IN-2
|
Complement System
|
Inflammation/Immunology
|
|
C5aR-IN-2 is a potent inhibitor of C5aR. Increased level of C5a has been associated with disorders such as autoimmune disorders and inflammatory disorders. C5aR-IN-2 has the potential for the research of inflammation diseases (extracted from patent WO2022028586A1, compound 49).
|
-
- HY-N2543
-
-
- HY-144032
-
|
Tyk2-IN-9
|
JAK
|
Inflammation/Immunology
|
|
Tyk2-IN-9 (Compound 26) is a selective Tyk-2 inhibitor with IC50s of 0.076 and 1.8 nM for TYK2-JH2 and JAK1-JH2, respectively. Tyk2-IN-9 can be used for the research of inflammatory or autoimmune disease.
|
-
- HY-131670
-
|
(±)9,10-DiHOME
|
Others
|
Inflammation/Immunology
|
|
(±)9,10-DiHOME is the racemate of 9,10-DiHOME. 9,10-DiHOME is a leukotoxin derivative of linoleic acid diol that has been reported to be toxic in human's tissue preparations, and is produced by inflammatory leukocytes such as neutrophils and macrophages.
|
-
- HY-W013812S2
-
|
Ethyl linoleate-d2
Linoleic Acid ethyl ester-d2; Mandenol-d2
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
Ethyl linoleate-d2 (Linoleic Acid ethyl ester-d2; Mandenol-d2) is the deuterium labeled Ethyl linoleate (HY-W013812). Ethyl linoleate (Linoleic Acid ethyl ester) inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators.
|
-
- HY-115977
-
|
Aldose reductase-IN-3
|
Aldose Reductase
|
Inflammation/Immunology
|
|
Aldose reductase-IN-3 (Compound 5) is a potent and moderately selective inhibitor of aldose reductase (AR) with an IC50 of 3.99 μM. Aldose reductase has recently emerged as a molecular target that is involved in various inflammatory diseases, including sepsis. Aldose reductase-IN-3 has the potential for the research of sepsis.
|
-
- HY-N1346
-
|
Robinin
|
Toll-like Receptor (TLR)
|
Inflammation/Immunology
|
|
Robinin is present in flavonoid fraction of Vigna unguiculata leaf. Robinin inhibits upregulated expression of TLR2 and TLR4. Robinin ameliorates oxidized low density lipoprotein (Ox-LDL) induced inflammatory insult through TLR4/NF-κB pathway.
|
-
- HY-146405
-
-
- HY-N7696
-
|
Physalin F
|
Apoptosis
|
Inflammation/Immunology
|
|
Physalin F is a secosteroid with potent anti-inflammatory and immunomodulatory activities. Physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by Human T-lymphotropic virus type 1 (HTLV-1) infection.
|
-
- HY-147263
-
-
- HY-105174
-
|
BPC 157
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
BPC 157 is a stable gastric pentadecapeptide and a partial sequence of the human gastric juice protein BPC. BPC 157 is an anti-ulcer peptidergic agent with no reported toxicity. BPC 157 links inflammatory bowel disease and multiple sclerosis.
|
-
- HY-148141
-
|
JPE-1375
|
Complement System
|
Inflammation/Immunology
|
|
JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization (EC50=6.9 µM) and reduces TNF levels (EC50=4.5 µM) in mice. JPE-1375 can be used in studies of autoimmune and inflammatory diseases.
|
-
- HY-14904
-
|
Umifenovir
|
SARS-CoV
Influenza Virus
|
Infection
|
|
Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro. Umifenovir shows anti-inflammatory activity.
|
-
- HY-144087
-
|
TYK2-IN-11
|
JAK
|
Inflammation/Immunology
|
|
TYK2-IN-11 (Compound 5B) is a selective Tyk-2 inhibitor with IC50s of 0.016 and 0.31 nM for TYK2-JH2 and JAK1-JH2, respectively. TYK2-IN-11 can be used for the research of inflammatory or autoimmune disease.
|
-
- HY-15337
-
|
Hesperidin
Hesperetin 7-rutinoside
|
Apoptosis
Autophagy
Reactive Oxygen Species
Endogenous Metabolite
|
Cancer
|
|
Hesperidin (Hesperetin 7-rutinoside), a flavanone glycoside, is isolated from citrus fruits. Hesperidin has numerous biological properties, such as decreasing inflammatory mediators and exerting significant antioxidant effects. Hesperidin also exhibits antitumor and antiallergic activities.
|
-
- HY-128348
-
|
PK68
|
RIP kinase
|
Cancer
Inflammation/Immunology
|
|
PK68 is a potent orally active and specifical type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90 nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and can be used for the research of inflammatory disorders and cancer metastasis.
|
-
- HY-P99335
-
|
Vunakizumab
Anti-Human IL17A Recombinant Antibody
|
Interleukin Related
|
Inflammation/Immunology
|
|
Vunakizumab (Anti-Human IL17A Recombinant Antibody) is a recombinant human IgGκ monoclonal antibody that targets IL-17A and inhibits its interaction with the IL-17 receptor. Vunakizumab can be used to study autoimmune diseases such as psoriatic arthritis, ankylosing spondylitis, multiple sclerosis and inflammatory arthritis.
|
-
- HY-15781
-
|
Morinidazole
|
Bacterial
|
Infection
|
|
Morinidazole is an orally active and 5-nitroimidazole antimicrobial agent that undergoes extensive metabolism in humans via N +-glucuronidation and sulfation. Morinidazole can be used for bacterial infections research including appendicitis and pelvic inflammatory disease (PID) caused by anaerobic bacteria.
|
-
- HY-N7652
-
|
Terminolic acid
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
Terminolic acid is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum. Terminolic acid can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. Terminolic acid also exhibits moderate antibacterial activity.
|
-
- HY-147105
-
|
LRH-1 modulator-1
|
Others
|
Inflammation/Immunology
|
|
LRH-1 modulator-1 (compound 6N) is a potent LRH-1 (liver receptor homolog-1) modulator/agonist. LRH-1 modulator-1 shows anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 induces anti-inflammatory cytokine IL-10, and reduces inflammatory cytokine IL-1b and TNFa.
|
-
- HY-N1162
-
|
Tetrahydroamentoflavone
Amentoflavanone
|
Xanthine Oxidase
|
Infection
Inflammation/Immunology
|
|
Tetrahydroamentoflavone (Amentoflavanone) is a potent xanthine oxidase (XO) inhibitor. Tetrahydroamentoflavone has inhibitory activity for XO with IC50 and Ki values of 92 nM and 0.982 μM, respectively. Tetrahydroamentoflavone can be used for the research of inflammatory disorders and gout.
|
-
- HY-N8680
-
-
- HY-137298
-
|
LTA4H-IN-1
|
Aminopeptidase
|
Inflammation/Immunology
|
|
LTA4H-IN-1 is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) extracted from patent WO2015092740A1, example 29, has an IC50 of 2 nM. LTA4H-IN-1 can be used for the research of inflammatory and autoimmune disorders.
|
-
- HY-145564A
-
-
- HY-15781A
-
|
(R)-Morinidazole
|
Bacterial
|
Infection
|
|
(R)-Morinidazole is an orally active and 5-nitroimidazole antimicrobial agent that undergoes extensive metabolism in humans via N +-glucuronidation and sulfation. (R)-Morinidazole can be used for bacterial infections research including appendicitis and pelvic inflammatory disease (PID) caused by anaerobic bacteria.
|
-
- HY-148068
-
|
STING agonist-20
|
STING
|
Cancer
Inflammation/Immunology
|
|
STING agonist-20 (compound 95) is a potent STING agonist used in the synthesis of XMT-2056. STING agonist-20 can be used as a vaccine adjuvant in the study of cancer and other inflammatory, immune diseases.
|
-
- HY-137941
-
|
Roxatidine
|
Histamine Receptor
|
Inflammation/Immunology
|
|
Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is a histamine H2-receptor antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect.
|
-
- HY-117426
-
|
MO-I-500
|
Others
|
Cancer
|
|
MO-I-500 is a pharmacological of FTO inhibitor with an IC50 of 8.7 μM for the inhibition of purified FTO demethylase catalyzing demethylation of an artificial small methylated substrate. MO-I-500 can be used for the research of rare panresistant triple-negative inflammatory breast cancer.
|
-
- HY-16726
-
|
Polmacoxib
CG100649
|
COX
Carbonic Anhydrase
|
Cancer
|
|
Polmacoxib (CG100649) is a first-in-class, orally active nonsteroidal anti-inflammatory agent (NSAID) which is a dual inhibitor of COX-2 (IC50 around 0.1 μg/ml) and carbonic anhydrase. Polmacoxib inhibits colorectal adenoma and tumor growth in mouse models.
|
-
- HY-144373
-
-
- HY-136427
-
-
- HY-B1616
-
-
- HY-W013164
-
|
SC-58125
|
COX
|
Cancer
Inflammation/Immunology
|
|
SC-58125 is a potent and selective inhibitor of cyclooxygenase 2 (COX-2), with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo. SC-58125 also can inhibit edema at the inflammatory site and has analgesic effect.
|
-
- HY-D0861
-
|
EGTA
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca 2+ over Mg 2+ (Mg 2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages.
|
-
- HY-151391
-
|
LPA5 antagonist 1
|
Others
|
Neurological Disease
|
|
LPA5 antagonist 1 (Compound 66) is a potent and selective lysophosphatidic acid receptor 5 (LPA5) antagonist (IC50=32 nM). LPA5 antagonist 1 shows high brain permeability and anti-nociceptive activity. LPA5 antagonist 1 can be used in inflammatory and neuropathic pain research.
|
-
- HY-142980
-
|
Dioleoylphosphatidylglycerol
DOPG
|
Liposome
|
Inflammation/Immunology
|
|
Dioleoylphosphatidylglycerol (DOPG) is a naturally occurring phospholipid that can be produced by the combined action of aquaporin 3 (AQP3) and phospholipase D2 (PLD2). Dioleoylphosphatidylglycerol inhibits macrophage inflammatory mediator production in response to heat shock protein B4 (HSPB4) activation of toll-like receptor 2 (TLR2) .
|
-
- HY-117066
-
|
CL075
3M002
|
Toll-like Receptor (TLR)
|
Inflammation/Immunology
|
|
CL075 (3M002) is a selective TLR8 agonist with immunomodulating properties. CL075 triggers a MyD88-dependent signaling pathway to elicit production of inflammatory cytokines and type I interferons (IFNs) via activation of NF-κB and IRF7, respectively.
|
-
- HY-17474A
-
|
Parecoxib Sodium
SC 69124A
|
COX
|
Inflammation/Immunology
Cancer
|
|
Parecoxib Sodium (SC 69124A) is a highly selective?and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib Sodium can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.
|
-
- HY-17474
-
|
Parecoxib
SC 69124
|
COX
|
Cancer
Inflammation/Immunology
|
|
Parecoxib (SC 69124) is a highly selective?and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.
|
-
- HY-15707
-
|
NS6180
|
Potassium Channel
|
Inflammation/Immunology
|
|
NS6180 is a new orally active KCa3.1 channel inhibitor. NS6180 inhibits cloned human KCa3.1 channels with an IC50value of 9 nM. NS6180 can be used for the research of inflammatory bowel disease (IBD) .
|
-
- HY-13507
-
|
Lumiracoxib
COX-189
|
COX
|
Cancer
Metabolic Disease
Inflammation/Immunology
|
|
Lumiracoxib is a potent,selective and orally active COX-2 inhibitor with a Ki value of 0.06 μM. Lumiracoxib acts as a nonselective NSAID with anti-inflammatory, analgesic and antipyretic activities. Lumiracoxib can be used for osteoarthritis and bone cancer research.
|
-
- HY-Q45780
-
|
ZINC00640089
|
Akt
|
Cancer
|
|
ZINC00640089 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00640089 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. ZINC00640089 has good potential for research in inflammatory breast cancer (IBC).
|
-
- HY-148364
-
|
ZINC00784494
|
Others
|
Cancer
|
|
ZINC00784494 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00784494 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. ZINC00784494 has good potential for research in inflammatory breast cancer (IBC).
|
-
- HY-D0861A
-
|
EGTA tetrasodium
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca 2+ over Mg 2+ (Mg 2+ Kd 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages.
|
-
- HY-109143
-
|
Elsubrutinib
ABBV-105
|
Btk
|
Inflammation/Immunology
|
|
Elsubrutinib (ABBV-105) is an orally active, potent, selective and irreversible Bruton's tyrosine kinase (BTK) inhibitor。The IC50 of Elsubrutinib for BTK catalytic domain is 0.18 μM. Elsubrutinib can be used for the research of inflammatory disease.
|
-
- HY-146334
-
|
DFBTA
|
Chloride Channel
|
Inflammation/Immunology
|
|
DFBTA is an orally active, potent and little brain penetrated ANO1 (Calcium-activated chloride channel anoctamin-1) inhibitor, with an IC50 of 24 nM. DFBTA shows analgesic efficacy for inflammatory pain.
|
-
- HY-107426
-
|
Verrucarin A
Muconomycin A
|
Apoptosis
Reactive Oxygen Species
|
Cancer
|
|
Verrucarin A (Muconomycin A), a Type D macrocyclic mycotoxin derived from the pathogen fungus Myrothecium verrucaria, is an inhibitor of protein synthesis. Verrucarin A inhibits growth of leukemia cell lines and activates caspases and apoptosis and inflammatory signaling in macrophages. Verrucarin A effectively increased the phosphorylation of p38 MAPK and diminished the phosphorylation of ERK/Akt. Verrucarin A caused cell cycle deregulation through the induction of p21 and p53.
|
-
- HY-133130
-
|
JNJ-42226314
|
MAGL
|
Neurological Disease
|
|
JNJ-42226314 is a competitive, highly selective and reversible non-covalent monoacylglycerol lipase (MAGL) inhibitor. JNJ-42226314 demonstrates dose-dependent enhancement of the major endocannabinoid 2-arachidonoylglycerol (2-AG) as well as efficacy in models of neuropathic and inflammatory pain.
|
-
- HY-P99450
-
|
Avdoralimab
IPH 5401; Anti-C5aR1 mAb
|
Complement System
|
Cancer
Inflammation/Immunology
|
|
Avdoralimab (IPH 5401) is a fully human IgGκ monoclonal antibody that targets the complement C5a receptor 1 (C5aR1) that prevents its binding to C5a. Avdoralimab can be used for complement-driven inflammatory diseases and solid tumours research.
|
-
- HY-117616
-
|
Laurotetanine
(+)-Laurotetanine
|
NF-κB
|
Cancer
|
|
Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways.
|
-
- HY-N6894
-
|
Pseudocoptisine acetate
Isocoptisine acetate
|
Cholinesterase (ChE)
|
Inflammation/Immunology
|
|
Pseudocoptisine (Isocoptisine) acetate is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine acetate inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects.
|
-
- HY-P1116
-
|
PBP10
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects.
|
-
- HY-143485
-
|
IRAK4-IN-9
|
IRAK
|
Cancer
Inflammation/Immunology
|
|
IRAK4-IN-9 (compound 73) is a potent IRAK4 inhibitor with an IC50 of 1.5 nM. IRAK4-IN-9 blocks MyD88 dependent signaling. IRAK4-IN-9 has the potential for the research of inflammatory diseases, autoimmune diseases, and cancer.
|
-
- HY-143486
-
|
IRAK4-IN-10
|
IRAK
|
Cancer
Inflammation/Immunology
|
|
IRAK4-IN-10 (compound 75) is a potent IRAK4 inhibitor with an IC50 of 1.5 nM. IRAK4-IN-10 blocks MyD88 dependent signaling. IRAK4-IN-9 has the potential for the research of inflammatory diseases, autoimmune diseases, and cancer.
|
-
- HY-144276
-
|
RIPK1-IN-11
|
RIP kinase
|
Inflammation/Immunology
|
|
RIPK1-IN-11 is a potent and orally active RIPK1 inhibitor (Kd=9.2 nM; IC50=67 nM). RIPK1-IN-11 inhibits necroptosis in both human and mouse cells (EC50=17-30 nM). Anti-inflammatory activity.
|
-
- HY-129421
-
|
PA-9
|
Others
|
Inflammation/Immunology
Neurological Disease
|
|
PA-9 is a pituitary adenylate cyclase-activating polypeptide (PACAP) type I (PAC1) receptor antagonist. PA-9 dose dependently inhibits PACAP-induced cAMP elevation with an IC50 of 5.6 nM. PA-9 can be used for the research of neuropathic and/or inflammatory pain.
|
-
- HY-16990
-
|
Ac-YVAD-cmk
Caspase-1 Inhibitor II
|
Caspase
|
Inflammation/Immunology
|
|
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases.
|
-
- HY-17589
-
-
- HY-17589B
-
-
- HY-146155
-
-
- HY-17589A
-
-
- HY-101293
-
-
- HY-P99519
-
|
Vixarelimab
KPL-716
|
Interleukin Related
|
Inflammation/Immunology
|
|
Vixarelimab (KPL-716) is a human anti-oncostatin M (OSM) monoclonal antibody that binds to the beta chain of the OSM receptor and inhibits IL-31 and OSM signalling. Vixarelimab can be used in studies of inflammatory skin diseases such as atopic dermatitis and itchy nodular rash.
|
-
- HY-12820
-
|
Sibofimloc
Antibiotic-202
|
Bacterial
Antibiotic
|
Infection
|
|
Sibofimloc (Antibiotic-202) is a first-in-class, gut-restricted, orally active FimH adhesion inhibitor extracted from patent WO2014100158A1, Compound Example 202. Sibofimloc has anti-bacterial infective activity. Sibofimloc is developed for inflammatory bowel disease (IBD).
|
-
- HY-147240
-
-
- HY-11109
-
-
- HY-111675
-
|
Ac-FLTD-CMK
|
Caspase
Pyroptosis
|
Inflammation/Immunology
|
|
Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3.
|
-
- HY-129113
-
|
α-Chaconine
|
COX
|
Inflammation/Immunology
|
|
α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects.
|
-
- HY-145855
-
|
J-1063
|
TGF-β Receptor
|
Inflammation/Immunology
|
|
J-1063 is a potent, selective and orally active ALK5 inhibitor with an IC50 of 0.039 µM. J-1063 shows anti-fibrotic effect by the inhibition of inflammatory infiltration, collagen deposition, and hepatocytes necrosis. J-1063 has the potential for the research of liver fibrosis.
|
-
- HY-15178
-
|
Oglemilast
GRC 3886
|
Phosphodiesterase (PDE)
|
Inflammation/Immunology
|
|
Oglemilast (GRC 3886) is a potent and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 0.5 nM for PDE4D3. Oglemilast inhibits pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast has the potential for inflammatory airway diseases.
|
-
- HY-151174
-
|
PDE4-IN-12
|
Phosphodiesterase (PDE)
|
Inflammation/Immunology
|
|
PDE4-IN-12 is a potent pan-PDE4 inhibitor, with IC50s of 3.5 and 15 nM for PDE4 and PDE7, respectively (SI=2.71 and 4.27, respectively). PDE4-IN-12 shows well tolerated, can be used in study of inflammatory bowel diseases (IBDs).
|
-
- HY-114883A
-
|
Homocarnosine TFA
L-Homocarnosine TFA; γ-Aminobutyryl-L-histidine TFA
|
GABA Receptor
Endogenous Metabolite
|
Neurological Disease
|
|
Homocarnosine TFA is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine TFA is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects. Homocarnosine TFA has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation.
|
-
- HY-13723
-
-
- HY-144041
-
|
CSF1R-IN-5
|
c-Fms
|
Cancer
|
|
CSF1R-IN-5 is a potent inhibitor of CSF1R. CSF-1R is expressed in macrophages, and the survival and differentiation of macrophages depends on the CSF-1/CSF-1R signaling pathway. CSF1R-IN-5 affects the exchange of inflammatory factors between TAMs and glioma cells. CSF1R-IN-5 has the potential for the research of cancer disease (extracted from patent WO2021197276A1, compound 11).
|
-
- HY-144040
-
|
CSF1R-IN-4
|
c-Fms
|
Cancer
|
|
CSF1R-IN-4 is a potent inhibitor of CSF1R. CSF-1R is expressed in macrophages, and the survival and differentiation of macrophages depends on the CSF-1/CSF-1R signaling pathway. CSF1R-IN-4 affects the exchange of inflammatory factors between TAMs and glioma cells. CSF1R-IN-4 has the potential for the research of cancer disease (extracted from patent WO2021197276A1, compound 104).
|
-
- HY-144042
-
|
CSF1R-IN-6
|
c-Fms
|
Cancer
|
|
CSF1R-IN-6 is a potent inhibitor of CSF1R. CSF-1R is expressed in macrophages, and the survival and differentiation of macrophages depends on the CSF-1/CSF-1R signaling pathway. CSF1R-IN-6 affects the exchange of inflammatory factors between TAMs and glioma cells. CSF1R-IN-6 has the potential for the research of cancer disease (extracted from patent WO2021197276A1, compound 5).
|
-
- HY-147584
-
|
BTK-IN-14
|
Btk
|
Cancer
Inflammation/Immunology
|
|
BTK-IN-14 is a potent inhibitor of BTK. BTK plays an important role in signaling mediated by B cell antigen receptor (BCR) and Fcγreceptor (FcγR) in B cells and myeloid cells, respectively. BTK-IN-14 has the potential for the research of related diseases, especially autoimmune diseases, inflammatory diseases or cancer (extracted from patent WO2022057894A1, compound 1).
|
-
- HY-110133
-
|
JTE-607
|
Interleukin Related
|
Inflammation/Immunology
|
|
JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including TNF-α, IL-1β, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607.
|
-
- HY-145564
-
|
Emprumapimod
PF-07265803
|
p38 MAPK
|
Inflammation/Immunology
Cardiovascular Disease
|
|
Emprumapimod (PF-07265803) is a potent, orally active and selective inhibitor of p38α MAPK directly inhibits LPS-induced IL-6 production from RPMI-8226 cell (IC50=100 pM). Emprumapimod can be used for the research of dilated cardiomyopathy and acute inflammatory pain.
|
-
- HY-145909
-
|
BRD4 Inhibitor-17
|
Epigenetic Reader Domain
|
Cancer
|
|
BRD4 Inhibitor-17 (Compound 5i) is a potent inhibitor of BRD4 with an IC50 of 0.33 μM. BRD4 Inhibitor-17 plays crucial role in regulating transcription of inflammatory, proliferation and cell cycle genes. BRD4 Inhibitor-17 serves as potential antidotes for arsenicals.
|
-
- HY-N6934
-
-
- HY-124651
-
|
SEMBL
|
NF-κB
MMP
|
Cancer
Inflammation/Immunology
|
|
SEMBL is a potent NF-κB inhibitor. SEMBL can inhibit NF-κB-DNA binding, and also inhibits NF-κB-dependent inflammatory cytokine secretions. SEMBL inhibits cancer cell migration and invasion via decreasing MMP expression. SEMBL can be used for researching anticancer.
|
-
- HY-144738
-
|
Dual FAAH/sEH-IN-1
|
Epoxide Hydrolase
FAAH
|
Inflammation/Immunology
|
|
Dual FAAH/sEH-IN-1 (compound 3) is a high affinity dual sEH (soluble epoxide hydrolase) and FAAH (fatty acid amide hydrolase) inhibitor, with IC50 values of 9.6 and 7 nM, respectively. Dual FAAH/sEH-IN-1 shows antinociception against the inflammatory phase.
|
-
- HY-147581
-
|
BTK-IN-11
|
Btk
|
Cancer
Inflammation/Immunology
|
|
BTK-IN-11 is a potent inhibitor of BTK. BTK plays an important role in signaling mediated by B cell antigen receptor (BCR) and Fcγreceptor (FcγR) in B cells and myeloid cells, respectively. BTK-IN-11 has the potential for the research of related diseases, especially autoimmune diseases, inflammatory diseases or cancer (extracted from patent WO2022063101A1, compound Z2).
|
-
- HY-145801
-
|
XT2
|
Others
|
Inflammation/Immunology
|
|
XT2 is a potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK) with an IC50 of 9.1 nM. XT2 suppresses CCl4-induced upregulation of ALT, a key biomarker of acute liver injury. XT2 also decreases immune cell infiltration into the injured liver tissue. XT2 has the potential for the research of liver inflammatory diseases.
|
-
- HY-P1832
-
|
PTD-p65-P1 Peptide
|
NF-κB
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
PTD-p65-P1 Peptide is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis.
|
-
- HY-P1217
-
|
[D-Trp8]-γ-MSH
|
Melanocortin Receptor
|
Inflammation/Immunology
|
|
[D-Trp8]-γ-MSH is a potent and selective agonist of melanocortin 3 (MC3) receptor, with IC50s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4 and hMC5, respectively in CHO cells. [D-Trp8]-γ-MSH could provide protection against multiple inflammatory disorders such as rheumatoid arthritis and colitis.
|
-
- HY-147808
-
-
- HY-146478
-
|
A1/A3 AR antagonist 1
|
Adenosine Receptor
|
Inflammation/Immunology
Neurological Disease
|
|
A1/A3 AR antagonist 1 (compound 10) is a potent adenosine 1 (A1) and adenosine 3 (A3) receptor dual antagonist with Kis of 36.7 nM, 25.4 nM and 1.47 nM for human A1, human A3 and rat A1, respectively. A1/A3 AR antagonist 1 can be used for researching kidney failure, inflammatory pulmonary diseases, and Alzheimer’s disease.
|
-
- HY-131019
-
|
JF-NP-26
|
mGluR
|
Neurological Disease
|
|
JF-NP-26, an inactive photocaged derivative of raseglurant, is the first caged mGlu5 receptor negative allosteric modulator. Uncaging of JF-NP-26 is elicited with light pulses in the visible spectrum (405 nm). JF-NP-26 induces light-dependent analgesia in models of inflammatory and neuropathic pain in freely behaving animals.
|
-
- HY-114981
-
|
SRTCX1002
|
Sirtuin
|
Inflammation/Immunology
|
|
SRTCX1002 is a potent activator of SIRT1 (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC50s of 0.71 and 7.58 µM, respectively.
|
-
- HY-P1832A
-
|
PTD-p65-P1 Peptide TFA
|
NF-κB
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis.
|
-
- HY-P1217A
-
|
[D-Trp8]-γ-MSH TFA
|
Melanocortin Receptor
|
Inflammation/Immunology
|
|
[D-Trp8]-γ-MSH TFA is a potent and selective agonist of melanocortin 3 (MC3) receptor, with IC50s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4 and hMC5, respectively in CHO cells. [D-Trp8]-γ-MSH TFA could provide protection against multiple inflammatory disorders such as rheumatoid arthritis and colitis.
|
-
- HY-P99486
-
|
Briakinumab
ABT-874
|
Interleukin Related
|
Inflammation/Immunology
|
|
Briakinumab (ABT-874) is a fully human anti-IL-12/23p40 monoclonal antibody. Briakinumab targets and neutralizes IL-12 and IL-23. Briakinumab can be used for the research of rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis.
|
-
- HY-101402
-
|
Cyclo(his-pro)
Cyclo(histidyl-proline); Histidylproline diketopiperazine
|
NF-κB
Endogenous Metabolite
|
Inflammation/Immunology
Neurological Disease
|
|
Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses.
|
-
- HY-W001174
-
-
- HY-W181102
-
|
NFAT Inhibitor-2
|
Others
|
Inflammation/Immunology
Neurological Disease
Cardiovascular Disease
|
|
NFAT Inhibitor-2 is a potent inhibitor of calcineurin NFAT signalling. Calcineurin is a serine/threonine protein phosphatase regulated by Ca2+ and calmodulin. NFAT Inhibitor-2 has the potential for the research of inflammatory disease, an autoimmune disorder, a cardiovascular disease, a neurodegenerative disease, a disease occurring with uncontrolled cell proliferation and/or differentiation, an angiogenesis-related disease, an allergy, anaphylaxis and alopecia (extracted from patent WO2016207212A1, compound 17).
|
-
- HY-148382
-
-
- HY-P99184
-
-
- HY-B0446
-
-
- HY-118140
-
|
ZCZ011
|
Cannabinoid Receptor
|
Inflammation/Immunology
Neurological Disease
|
|
ZCZ011 is a potent and brain penetrant cannabinoid 1 (CB1) receptor positive allosteric modulator. ZCZ011 potentiates binding of CP55,940 to the CB1 receptor, enhances anandamide (AEA)-stimulated GTPγS binding in mouse brain membranes. ZCZ011 increases β-arrestin recruitment and ERK phosphorylation in hCB1 cells. ZCZ011 can be used for researching neuropathic and inflammatory pain.
|
-
- HY-145578
-
|
Linaprazan glurate
X842
|
Others
|
Inflammation/Immunology
|
|
Linaprazan glurate inhibits exogenously or endogenously stimulated gastric acid secretion. Linaprazan glurate exhibits several advantageous properties, such as fast onset, high in vivo potency and/or long duration of action. Linaprazan glurate is useful in the research of gastrointestinal inflammatory diseases and peptic ulcer diseases (extracted from patent WO2010063876A1).
|
-
- HY-13591
-
|
Piclidenoson
IB-MECA; CF-101
|
Adenosine Receptor
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Piclidenoson (IB-MECA) is a first-in-class, orally active and selective A3 adenosine receptor (A3AR) agonist. Piclidenoson exhibits antiproliferative effect and induces apoptosis in different cancer cell types like melanoma, leukemia. Piclidenoson can be used for the research of autoimmune inflammatory diseases and COVID-19.
|
-
- HY-B2155
-
|
Acotiamide monohydrochloride trihydrate
|
Cholinesterase (ChE)
|
Metabolic Disease
Inflammation/Immunology
|
|
Acotiamide monohydrochloride trihydrate is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with IC50 of 1.79 μM. Acotiamide monohydrochloride trihydrate can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide monohydrochloride trihydrate has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory .
|
-
- HY-N3480
-
|
Isogosferol
(+)-Isogospherol; Isogospherol
|
Others
|
Inflammation/Immunology
|
|
Isogosferol ((+)-Isogospherol; Isogospherol) is a potent anti-inflammatory agent. Isogosferol decreases LPS (HY-D1056)-stimulated NO and IL-1β expression. Isogosferol decreases the LPS (HY-D1056)-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2.
|
-
- HY-143423A
-
|
(S)-MALT1-IN-5
|
MALT1
|
Cancer
Inflammation/Immunology
|
|
(S)-MALT1-IN-5 is a potent inhibitor of MALT1 protease. (S)-MALT1-IN-5 inhibits the activity of MALT1 is expected to be able to correct the enhancement of MALT1 activity due to abnormality of T cell receptor signal or B cell receptor signal, and cancer or inflammatory disease caused by MALT1 activity is expected. (S)-MALT1-IN-5 has the potential for the research of MALT1-related diseases (extracted from patent WO2020111087A1, compound 1).
|
-
- HY-101402A
-
|
Cyclo(his-pro) TFA
Cyclo(histidyl-proline) TFA; Histidylproline diketopiperazine TFA
|
NF-κB
Endogenous Metabolite
|
Inflammation/Immunology
Neurological Disease
|
|
Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) TFA could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses.
|
-
- HY-151392
-
-
- HY-P99031
-
|
Mavrilimumab
CAM 3001
|
c-Fms
|
Inflammation/Immunology
Cardiovascular Disease
|
|
Mavrilimumab (CAM 3001) is a monoclonal antibody that binds to the α subunit of the granulocyte-macrophage colony stimulating factor (GM-CSF) receptor and blocks intracellular signalling downstream of GM-CSF. GM-CSF might be a mediator of the hyperactive inflammatory response associated with respiratory failure and death.
|
-
- HY-152254
-
|
CB2R/FAAH modulator-3
|
FAAH
Cannabinoid Receptor
|
Cancer
Infection
Inflammation/Immunology
Neurological Disease
|
|
CB2R/FAAH modulator-3 (compound 27) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-3 are 20.1 and 67.6 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 3.4 μM. CB2R/FAAH modulator-3 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection.
|
-
- HY-152253
-
|
CB2R/FAAH modulator-2
|
FAAH
Cannabinoid Receptor
|
Cancer
Infection
Inflammation/Immunology
Neurological Disease
|
|
CB2R/FAAH modulator-2 (compound 26) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-2 are 10.8 and 152.9 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection.
|
-
- HY-11079
-
|
A-803467
|
Sodium Channel
|
Inflammation/Immunology
Neurological Disease
|
|
A-803467 is a potent and selective tetrodotoxin-resistant Nav1.8 sodium channel blocker (IC50=8 nM). A-803467 has shown significant anti-nociception in neuropathic and inflammatory pain models. A-803467 enhances the chemosensitivity of conventional anticancer agents through interaction with the ATP-binding cassette subfamily G member 2 (ABCG2) transporter.
|
-
- HY-15509A
-
|
Semapimod tetrahydrochloride
CNI-1493; CPSI-2364 tetrahydrochloride
|
TNF Receptor
Interleukin Related
p38 MAPK
|
Inflammation/Immunology
|
|
Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC50≈0.3 μM). Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders.
|
-
- HY-114011
-
-
- HY-11048
-
|
NS11394
|
GABA Receptor
|
Neurological Disease
|
|
NS11394 is an orally active and unique subtype-selective GABAA positive allosteric receptor (PAM), with a Ki of ~0.5 nM. NS11394 shows a selectivity profile in the order of GABAA-5 > α3 > α2 > α1-containing receptors. NS11394 has anxiolytic and anti-inflammatory properties.
|
-
- HY-N10504
-
|
Galactofucan
Fucogalactan
|
HSV
|
Cancer
Inflammation/Immunology
|
|
Galactofucan (Fucogalactan) is a sulfated polysaccharide. Galactofucan can be extracted from brown seaweed Saccharina longicruris with anticoagulant, anti-tumor, anti-thrombosis, anti-inflammatory and antiviral properties. Galactofucan shows antiviral activities to HSV-1 and HSV-2 with IC50s of 0.76 and 1.34 µg/mL, respectively. Galactofucan can be used for the research of cancer and inflammation.
|
-
- HY-19269
-
|
FK706
|
Elastase
|
Inflammation/Immunology
|
|
FK706 is a potent, slow-binding and competitive inhibitor of human neutrophil elastase with an IC50 of 83 nM and a Ki of 4.2 nM. FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase with IC50s of 22 nM and 100 nM, respectively, and has no inhibitory activity against other serine proteinases such as human pancreatic trypsin, human pancreatic α-chymotrypsin and human leukocyte cathepsin G. FK706 has anti-inflammatory effect.
|
-
- HY-141547
-
|
Nav1.7-IN-8
|
Sodium Channel
Cytochrome P450
|
Inflammation/Immunology
|
|
Nav1.7-IN-8 is a potent blockage of NaV1.7 with high selectivity for the inhibition of NaV1.7 over the subtypes hNaV1.1 and hNaV1.5. Nav1.7-IN-8 inhibits CYP2C9 and CYP3A4 with an IC50 of 0.17 μM and 0.077 μM, respectively. Nav1.7-IN-8 displays significant analgesic effects in rodent models of acute and inflammatory pain.
|
-
- HY-147579
-
|
Axl-IN-12
|
TAM Receptor
|
Cancer
Infection
Inflammation/Immunology
|
|
Axl-IN-12 (Example 2) is a potent AXL inhibitor. Axl-IN-12 can be used for the research of proliferative diseases, autoimmune diseases, allergic diseases, inflammatory diseases, transplant rejection, cancers, viral infectious diseases or other diseases of mammals.
|
-
- HY-13499
-
|
CCR2 antagonist 5
|
CCR
|
Inflammation/Immunology
|
|
CCR2 antagonist 5 is a selective, orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM). CCR2 antagonist 5 displays a Ki of 9.6 µM for mCCR2 binding. CCR2 antagonist 5 can be used in the research of inflammatory disease.
|
-
- HY-113919
-
|
Nothofagin
|
Calcium Channel
|
Inflammation/Immunology
|
|
Nothofagin, a dihydrochalcone, is isolated from rooibos (Aspalathus linearis). Nothofagin downregulates NF-κB translocation through blocking calcium influx. Nothofagin has antioxidant activity and ameliorates various inflammatory responses such as the septic response and vascular inflammation.
|
-
- HY-15701
-
|
Leukadherin-1
|
Integrin
Complement System
|
Inflammation/Immunology
|
|
Leukadherin-1, a specific agonist of the leukocyte surface integrin CD11b/CD18, increases CD11b/CD18-dependent cell adhesion to fibrinogen with an EC50 of 4 μM. Leukadherin-1 enhances leukocyte adhesion to ligands (such as ICAM-1) and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites. Leukadherin-1 suppresses innate inflammatory signaling.
|
-
- HY-P3507
-
|
Dalazatide
ShK-186
|
Potassium Channel
|
Metabolic Disease
Inflammation/Immunology
|
|
Dalazatide (ShK-186) is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease.
|
-
- HY-142701
-
|
SSTR4 agonist 4
|
Somatostatin Receptor
|
Neurological Disease
|
|
SSTR4 agonist 4 is a potent agonist of SSTR4. SSTR4 is expressed at relatively high levels in the hippocampus and neocortex, memory and learning regions, and Alzheimer's disease pathology. SSTR4 agonists are potent in rodent models of pain associated with acute and chronic associated anti-peripheral nociceptive and anti-inflammatory activity. SSTR4 agonist 4 has the potential for the research of pain (extracted from patent WO2021233428A1, compound 14).
|
-
- HY-142700
-
|
SSTR4 agonist 3
|
Somatostatin Receptor
|
Neurological Disease
|
|
SSTR4 agonist 3 is a potent agonist of SSTR4. SSTR4 is expressed at relatively high levels in the hippocampus and neocortex, memory and learning regions, and Alzheimer's disease pathology. SSTR4 agonists are potent in rodent models of pain associated with acute and chronic associated anti-peripheral nociceptive and anti-inflammatory activity. SSTR4 agonist 3 has the potential for the research of pain (extracted from patent WO2021233427A1, compound 14).
|
-
- HY-147578
-
|
Axl-IN-11
|
TAM Receptor
|
Cancer
Infection
Inflammation/Immunology
|
|
Axl-IN-11 (Example 1) is a potent AXL inhibitor. Axl-IN-11 can be used for the research of proliferative diseases, autoimmune diseases, allergic diseases, inflammatory diseases, transplant rejection, cancers, viral infectious diseases or other diseases of mammals.
|
-
- HY-151873
-
|
SZM679
|
RIP kinase
|
Inflammation/Immunology
|
|
SZM679 is a potent, orally active and selective RIPK1 inhibitor with Kd values of 8.6 nM and >5000 nM for RIPK1 and RIPK3, respectively. SZM679 reverses the tumor necrosis factor-induced systemic inflammatory response. SZM679 decreases the Tau hyperphosphorylation, neuroinflammation, and the RIPK1 phosphorylation level in the hippocampus and cortex. SZM679 can be used in research of Alzheimer's disease (AD).
|
-
- HY-19344
-
|
Lifitegrast
SAR 1118; SHP-606
|
Integrin
|
Inflammation/Immunology
|
|
Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease.
|
-
- HY-19344A
-
|
Lifitegrast sodium
SAR 1118 sodium; SHP-606 sodium
|
Integrin
|
Inflammation/Immunology
|
|
Lifitegrast (SAR 1118) sodium is a potent integrin antagonist. Lifitegrast sodium blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast sodium inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast sodium can be used for researching dry eye disease.
|
-
- HY-142444
-
|
SSAO/VAP-1 inhibitor 1
|
AP-1
|
Metabolic Disease
|
|
SSAO/VAP-1 inhibitor 1 is a potent inhibitor of SSAO/VAP-1. SSAO/VAP-1 promotes the transfer of Glucose transport 4 (GLUT 4) from adipocytes to the cell membrane, thereby regulating glucose transport. In endothelial cells, SSAO/VAP-1 can mediate the adhesion and exudation of leukocytes and endothelial cells, and participate in inflammatory responses. SSAO/VAP-1 inhibitor 1 has the potential for the research of inflammation and/or inflammation-related disease or diabetes and/or diabetes-related disease (extracted from patent WO2021102774A1, compound E3).
|
-
- HY-W033577
-
|
Tricarbonyldichlororuthenium(II) dimer
CORM-2
|
Others
|
Inflammation/Immunology
|
|
Tricarbonyldichlororuthenium(II) dimer is a pharmacological donor of CO releasing. CO releases from Tricarbonyldichlororuthenium(II) dimer prevents gastric mucosal oxidative damage induced by ischemia/reperfusion (I/R) improving gastric blood flow (GBF), decreasing DNA oxidation and inflammatory response on systemic level.
|
-
- HY-P3507A
-
|
Dalazatide TFA
ShK-186 TFA
|
Potassium Channel
|
Metabolic Disease
Inflammation/Immunology
|
|
Dalazatide (ShK-186) TFA is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide TFA can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease.
|
-
- HY-44809
-
|
Izilendustat
|
HIF/HIF Prolyl-Hydroxylase
|
Inflammation/Immunology
Cardiovascular Disease
|
|
Izilendustat is a potent inhibitor of prolyl hydroxylase which can stabilize hypoxia inducible factor- 1 alpha (HIF- lα) and hypoxia inducible factor-2 (HIF-2). Izilendustat has the potential for researching diseases that relate to the body’s inmmune response like colitis and other inflammatory bowel diseases (extracted from patent WO2011057115A1 and WO2011057121A1).
|
-
- HY-W107464
-
|
G6PDi-1
|
PDI
|
Metabolic Disease
Inflammation/Immunology
|
|
G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50 of 0.07 μM. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells.
|
-
- HY-114504
-
|
RVX-297
|
Epigenetic Reader Domain
|
Inflammation/Immunology
|
|
RVX-297 is a potent, orally active BET bromodomain inhibitor with selectivity for BD2. RVX-297 shows IC50s of 0.08, 0.05, and 0.02 μM for BRD2(BD2), BRD3(BD2), and BRD4(BD2), respectively. RVX-297 suppresses inflammatory gene expression in multiple immune cell types. RVX-297 is effective in acute inflammation and autoimmunity models.
|
-
- HY-N6588
-
|
3,4,5-Tricaffeoylquinic acid
3,4,5-triCQA
|
Akt
NF-κB
|
Inflammation/Immunology
|
|
3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases.
|
-
- HY-15568A
-
|
A-317491 sodium salt hydrate
|
P2X Receptor
|
Inflammation/Immunology
Neurological Disease
|
|
A-317491 sodium salt hydrate is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively. A-317491 sodium salt hydrate is highly selective (IC50>10 μM) over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes. A-317491 sodium salt hydrate reduces inflammatory and neuropathic pain by blocking P2X3 and P2X2/3 receptor-mediated calcium flux.
|
-
- HY-15568
-
|
A-317491
|
P2X Receptor
|
Inflammation/Immunology
Neurological Disease
|
|
A-317491 is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively. A-317491 is highly selective (IC50>10 μM) over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes. A-317491 reduces inflammatory and neuropathic pain by blocking P2X3 and P2X2/3 receptor-mediated calcium flux.
|
-
- HY-123986
-
|
CTPI-2
|
Mitochondrial Metabolism
|
Cancer
Inflammation/Immunology
|
|
CTPI-2 is a third-generation mitochondrial citrate carrier SLC25A1 inhibitor with a KD of 3.5 μM. CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet. Antitumor activity.
|
-
- HY-19618
-
|
BRD3308
|
HDAC
HIV
Apoptosis
|
Infection
Metabolic Disease
|
|
BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM. BRD3308 is 23-fold selectivity for HDAC3 over HDAC1 (IC50 of 1.26 μM) or HDAC2 (IC50 of 1.34 μM). BRD3308 suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines or glucolipotoxic stress, and increases functional insulin release. BRD3308 activates HIV-1 transcription and disrupts HIV-1 latency.
|
-
- HY-147576
-
|
Axl-IN-9
|
TAM Receptor
|
Cancer
Inflammation/Immunology
|
|
Axl-IN-9 (Example 10) is a potent AXL inhibitor, with an IC50 of 26 nM. Axl-IN-9 has excellent transmembrane properties. Axl-IN-9 exhibits excellent pharmacokinetic properties in an animal body. Axl-IN-9 can be used for the research of proliferative diseases, autoimmune diseases, allergic diseases, inflammatory diseases, transplant rejection, cancer, or other diseases in mammals.
|
-
- HY-147577
-
|
Axl-IN-10
|
TAM Receptor
|
Cancer
Inflammation/Immunology
|
|
Axl-IN-10 (Example 1) is a potent AXL inhibitor, with an IC50 of 5 nM. Axl-IN-10 has excellent transmembrane properties.Axl-IN-10 exhibits excellent pharmacokinetic properties in an animal body. Axl-IN-10 can be used for the research of proliferative diseases, autoimmune diseases, allergic diseases, inflammatory diseases, transplant rejection, cancer, or other diseases in mammals.
|
-
- HY-103461
-
|
FAAH-IN-6
|
FAAH
|
Neurological Disease
|
|
FAAH-IN-6 (compound 21d) is a potent, orally active and cross the blood-brain barrier fatty acid amide hydrolase (FAAH) inhibitor with IC50s of 0.72, 0.28 nM for hFAAH, rFAAH, respectively. FAAH-IN-6 shows dose-dependent analgesic efficacy in animal models of both neuropathic and inflammatory pain.
|
-
- HY-146346
-
|
HD-TAC7
|
PROTACs
HDAC
|
Inflammation/Immunology
|
|
HD-TAC7 is a potent PROTAC HDAC degrader with IC50 values of 3.6 μM, 4.2 μM and 1.1 μM for HDAC1, HDAC2 and HDAC3, respectively. HD-TAC7 can decreases NF-κB p65 in RAW 264.7 macrophages. HD-TAC7 can be used for the research of inflammatory diseases like asthma and chronic obstructive pulmonary disease (COPD).
|
-
- HY-111303
-
|
CHIC35
|
Sirtuin
|
Inflammation/Immunology
Neurological Disease
|
|
CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC50=0.124 µM). CHIC35 shows potential selective inhibition against SIRT1 over SIRT2 (IC50=2.8 µM) or SIRT3 (IC50>100 µM). CHIC35 has anti-inflammatory effects and can be used for CHARGE syndrome research.
|
-
- HY-142949
-
|
ALK5-IN-7
|
TGF-β Receptor
|
Cancer
Inflammation/Immunology
|
|
ALK5-IN-7 is a potent inhibitor of ALK5. Transforming growth factor beta (TGF-β) is a multifunctional cytokine that is involved in regulating cell proliferation, differentiation and apoptosis through complex receptor signaling pathways on the cell surface in an autocrine, paracrine and endocrine manner. ALK5-IN-7 has the potential for the research of TGF-β-related diseases and conditions, including but not limited to tumors, fibrotic diseases, inflammatory diseases, autoimmune diseases, etc (extracted from patent WO2021129621A1, compound 4).
|
-
- HY-142950
-
|
ALK5-IN-6
|
TGF-β Receptor
|
Cancer
Inflammation/Immunology
|
|
ALK5-IN-6 is a potent inhibitor of ALK5. Transforming growth factor beta (TGF-β) is a multifunctional cytokine that is involved in regulating cell proliferation, differentiation and apoptosis through complex receptor signaling pathways on the cell surface in an autocrine, paracrine and endocrine manner. ALK5-IN-6 has the potential for the research of TGF-β-related diseases and conditions, including but not limited to tumors, fibrotic diseases, inflammatory diseases, autoimmune diseases, etc (extracted from patent WO2021129621A1, compound 1).
|
-
- HY-19999A
-
|
PF-CBP1 hydrochloride
|
Epigenetic Reader Domain
Histone Acetyltransferase
|
Neurological Disease
|
|
PF-CBP1 hydrochloride is a highly selective inhibitor of the CREB binding protein bromodomain (CBP BRD). PF-CBP1 inhibits CREBBP and EP300 bromodomains with IC50 of 125 nM and 363 nM respectively. PF-CBP1 hydrochloride reduces LPS-induced inflammatory cytokines expression (IL-1β, IL-6 and IFN-β) in primary macrophages. PF-CBP1 hydrochloride also downregulates RGS4 expression cortical neurons and can be used for the research of neurological disorders, including epilepsy and parkinson's disease, et al.
|
-
- HY-151262
-
|
JAK-IN-23
|
JAK
STING
NF-κB
STAT
|
Inflammation/Immunology
|
|
JAK-IN-23 is an orally active double inhibitor of JAK/STAT and NF-κB. JAK-IN-23 can inhibit JAK1/2/3 with IC50 values of 8.9 nM, 15 nM and 46.2 nM, respectively. JAK-IN-23 has potent inhibitory activities against interferon-stimulated genes (ISG) and NF-κB pathways with IC50 values of 3.3 nM and 150.7 nM, respectively. JAK-IN-23 has great anti-inflammatory that decreases the release of various proinflammatory factors. JAK-IN-23 can be used for the research of inflammatory bowel disease (IBD).
|
-
- HY-P0063
-
|
Copper tripeptide
GHK-Cu
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Copper tripeptide (GHK-Cu) is a tripeptide. During wound healing, copper tripeptide may be freed from existing extracellular proteins via proteolysis and serves as a chemoattractant for inflammatory and endothelial cells. Copper tripeptide has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. Copper tripeptide is a natural modulator of multiple cllular pathways in skin regeneration.
|
-
- HY-N0664
-
|
Aucubin
|
Bacterial
|
Cancer
Infection
Inflammation/Immunology
Neurological Disease
|
|
Aucubin, an iridoid glucoside, is isolated from Plantago asiatica, Eucommia ulmoides, the leaves of Aucuba japonica and more recently from butterfly larva. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects.
|
-
- HY-P9984
-
|
Etrolizumab
rhuMAb Beta7; RG7413; PRO145223
|
Integrin
|
Cancer
|
|
Etrolizumab (rhuMAb Beta7) is a gut-selective, anti-β7 integrin monoclonal antibody. Etrolizumab is specific targeting of the β7 subunit of α4β7 and αEβ7 integrins with Ki values of 18 nM and 1800 pM for Human α4β7 and Human αEβ7-293, respectively. Etrolizumab can be used in research of inflammatory bowel disease (IBD).
|
-
- HY-147108
-
-
- HY-101283
-
|
HCH6-1
|
Formyl Peptide Receptor (FPR)
|
Inflammation/Immunology
|
|
HCH6-1 is a potent and competitive dipeptide antagonist of Formyl peptide receptor 1 (FPR1). HCH6-1 inhibits chemotaxis, superoxide anion generation, and elastase release in human neutrophils specifically activated by fMLF (an FPR1 agonist). HCH6-1 has protective effects against acute lung injury (ALI) in vivo and can be used for the research of FPR1-involved inflammatory lung diseases.
|
-
- HY-136535
-
|
Anizatrectinib
hTrkA-IN-1
|
Trk Receptor
|
Inflammation/Immunology
|
|
Anizatrectinib (hTrkA-IN-1) is a potent and orally active inhibitor of TrkA kinase with an IC50 of 1.3 nM, compound 2 extracted from patent WO2015175788. Anizatrectinib can be used for the study of inflammatory disease, such as prostatitis, pelvic, et al.
|
-
- HY-P4040
-
-
- HY-115620
-
|
AQX-016A
|
Phosphatase
PI3K
TNF Receptor
|
Inflammation/Immunology
|
|
AQX-016A is an orally active and potent SHIP1 agonist. AQX-016A can activate recombinant SHIP1 enzyme in vitro and stimulate SHIP1 activity. AQX-016A also can inhibit the PI3K pathway and TNFa production, can be useful for various inflammatory diseases research.
|
-
- HY-P1220
-
|
Huwentoxin-IV
|
Sodium Channel
|
Neurological Disease
|
|
Huwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV has analgesic effects on animal models of inflammatory and neuropathic pain.
|
-
- HY-15800
-
|
CZC-25146 hydrochloride
|
LRRK2
|
Inflammation/Immunology
Neurological Disease
|
|
CZC-25146 hydrochloride is a potent LRRK2 inhibitor with IC50 values of 4.76 nM and 6.87 nM for wild-type LRRK2 and G2019S LRRK2, respectively. CZC-25146 hydrochloride inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2C as well. CZC-25146 hydrochloride prevents mutant LRRK2-induced injury of neurons in vitro. CZC-25146 hydrochloride exhibits relatively favorable pharmacokinetic properties in mice. CZC-25146 hydrochloride can increase normal α-1-antitrypsin (AAT) secretion and reduce inflammatory cytokines. CZC-25146 hydrochloride can be used to research Parkinson's disease and liver diseases.
|
-
- HY-143885
-
|
JAK1/TYK2-IN-3
|
JAK
|
Inflammation/Immunology
|
|
JAK1/TYK2-IN-3 is a potent, selective and orally active dual TYK2/JAK1 inhibitor with IC50 values of 6 and 37 nM, respectively. JAK1/TYK2-IN-3 also shows selectively relative to JAK2 (IC50=140 nM) and JAK3 (IC50=362 nM). JAK1/TYK2-IN-3 shows anti-inflammatory effect by regulating the expression of related TYK2/JAK1-regulated genes, as well as the formation of Th1, Th2, and Th17 cells.
|
-
- HY-P1220A
-
|
Huwentoxin-IV TFA
|
Sodium Channel
|
Neurological Disease
|
|
Huwentoxin-IV TFA is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV TFA preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV TFA has analgesic effects on animal models of inflammatory and neuropathic pain.
|
-
- HY-15800A
-
|
CZC-25146
|
LRRK2
|
Inflammation/Immunology
Neurological Disease
|
|
CZC-25146 is a potent and orally active LRRK2 inhibitor with IC50 values of 4.76 nM and 6.87 nM for wild-type LRRK2 and G2019S LRRK2, respectively. CZC-25146 inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2C as well. CZC-25146 prevents mutant LRRK2-induced injury of neurons in vitro. CZC-25146 exhibits relatively favorable pharmacokinetic properties in mice. CZC-25146 can increase normal α-1-antitrypsin (AAT) secretion and reduce inflammatory cytokines. CZC-25146 can be used to research Parkinson's disease and liver diseases.
|
-
- HY-136233
-
|
PSB 0777 ammonium
|
Adenosine Receptor
|
Inflammation/Immunology
|
|
PSB 0777 ammonium is a potent and selective adenosine A2A receptor full agonist with Ki values of 44.4 nM, 360 nM for rat and human A2A receptors, respectively. PSB 0777 ammonium has Ki values of ≥10000 nM, 541 nM for rat and human A1 receptors, respectively. PSB 0777 ammonium shows poor brain penetrant and perorally non-absorbable effect. PSB 0777 ammonium has the potential for inflammatory bowel disease (IBS) research research.
|
-
- HY-115497
-
|
BRD5529
|
E1/E2/E3 Enzyme
|
Infection
Inflammation/Immunology
|
|
BRD5529 is an effective dose-dependent CARD9-TRIM62 protein–protein interaction (PPI) inhibitor with an IC50 value of 8.6 μM. BRD5529 has potency and complete inhibition of CARD9 ubiquitinylation in vitro, also has favorable solubility. BRD5529 can be used for the research of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC).
|
-
- HY-N8423
-
|
α-Amyrin
|
Others
|
Inflammation/Immunology
|
|
α-Amyrin is a pentacyclic triterpenoid. α-Amyrin has long-lasting antinociceptive and anti-inflammatory properties. α-Amyrin can be used for the research of inflammatory.
|
-
- HY-148264
-
-
- HY-B0174
-
-
- HY-14908
-
|
Vidofludimus
4sc-101; SC12267
|
Dihydroorotate Dehydrogenase
Interleukin Related
FXR
|
Infection
Inflammation/Immunology
|
|
Vidofludimus is an orally active inhibitor for dihydroorotate dehydrogenase (DHODH) and also is a novel modulator for farnesoid X receptor (FXR). Vidofludimus, as an immunomodulatory agent, can be used for the research of autoimmune disorders such as inflammatory bowel disease (IBD). Vidofludimus also can be used for the research of fatty liver by targeting FXR.
|
-
- HY-131997
-
|
2'MeO6MF
|
GABA Receptor
|
Inflammation/Immunology
Neurological Disease
|
|
2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors. 2'MeO6MF also can directly activate α2β2/3 and α2β2/3γ2L GABAA receptors. 2'MeO6MF has anxiolytic and psychomotor stabilizing properties. 2'MeO6MF offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response.
|
-
- HY-149052
-
-
- HY-131688
-
|
2-Chlorohexadecanoic acid
|
Others
|
Inflammation/Immunology
|
|
2-Chlorohexadecanoic acid, an inflammatory lipid mediator, interferes with protein palmitoylation,induces ER-stress markers, reduced the ER ATP content, and activates transcription and secretion of IL-6 as well as IL-8.2-Chlorohexadecanoic acid disrupts the mitochondrial membrane potential and induces procaspase-3 and PARP cleavage.2-Chlorohexadecanoic acid can across blood-brain barrier (BBB) and compromises ER- and mitochondrial functions in the human brain endothelial cell line hCMEC/D3.
|
-
- HY-146486
-
|
P2Y2R/GPR17 antagonist 1
|
P2Y Receptor
|
Inflammation/Immunology
|
|
P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R and GPR17 antagonist with IC50 values of 3.17 µM and 1.67 µM against P2Y2R and GPR17, respectively. P2Y2R/GPR17 antagonist 1 shows excellent metabolic stability in human liver microsomes.
|
-
- HY-111135
-
-
- HY-141645
-
|
IMM-H007
WS070117
|
AMPK
TGF-β Receptor
NF-κB
JNK
AP-1
|
Metabolic Disease
Inflammation/Immunology
Cardiovascular Disease
|
|
IMM-H007 (WS070117) is an orally active and potent AMPK (AMP-activated protein kinase) activator and TGFβ1 (transforming growth factor β1) antagonist. IMM-H007 has protective effects in cardiovascular diseases via activation of AMPK. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 degradation. IMM-H007 resolves hepatic steatosis in HFD-fed hamsters by the regulation of lipid metabolism. IMM-H007 can be used for the research of nonalcoholic fatty liver disease (NAFLD) and inflammatory atherosclerosis.
|
-
- HY-P1626
-
|
Acetyl tetrapeptide-15
|
Opioid Receptor
|
Neurological Disease
|
|
Acetyl tetrapeptide-15 is a synthetic peptide used in the cosmetics for sensitive skin. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway.
|
-
- HY-107831
-
-
- HY-111284
-
|
Kebuzone
Ketazone; Ketophenylbutazone
|
Others
|
Inflammation/Immunology
|
Kebuzone is a non-steroidal anti-inflammatory substance that may be studied in inflammatory diseases such as thrombophlebitis and rheumatoid arthritis.
|
-
- HY-P99496
-
|
Cendakimab
RPC 4046; ABT 308; CC-93538
|
Interleukin Related
|
Inflammation/Immunology
|
|
Cendakimab (RPC4046; ABT 308; CC-93538) is a selective, humanized, recombinant monoclonal antibody against the IL-13 molecule. Cendakimab has a high affinity and potency for both human wild-type and variant IL-13 and blocks binding of IL-13 to both IL-13Rα1 and IL-13Rα2 with IC50s of 352 pM and 631 pM by ELISA, respectively. Cendakimab recognizes both wild-type human IL-13 and the common polymorphic variant R110Q, with binding affinities of 52 and 50 pM, respectively. Cendakimab has the potential for IL-13-related allergic/inflammatory diseases (e.g., asthma and eosinophilic esophagitis).
|
-
- HY-17361
-
|
Etofenamate
|
COX
|
Inflammation/Immunology
|
|
Etofenamate, a non-steroid anti-inflammatory agent (NSAID) and a non-selective COX inhibitor, possesses analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties. Etofenamate is used in the research for osteoarthritis, arthritis and other inflammatory diseases.
|
-
- HY-N10114
-
-
- HY-14908A
-
|
Vidofludimus hemicalcium
4sc-101 hemicalcium; SC12267 hemicalcium
|
Dihydroorotate Dehydrogenase
Interleukin Related
FXR
|
Infection
Inflammation/Immunology
|
|
Vidofludimus (4sc-101; SC12267) hemicalcium is an orally active inhibitor for dihydroorotate dehydrogenase (DHODH) and also is a novel modulator for farnesoid X receptor (FXR). Vidofludimus hemicalcium, as an immunomodulatory agent, can be used for the research of autoimmune disorders such as inflammatory bowel disease (IBD). Vidofludimus hemicalcium also can be used for the research of fatty liver by targeting FXR.
|
-
- HY-151093
-
-
- HY-N1388
-
|
Tussilagone
|
Others
|
Inflammation/Immunology
|
|
Tussilagone, a major active component in Tussilago farfara, has anti-inflammatory effect. Tussilagone ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Tussilagone inhibits the inflammatory response and improves survival in cecal ligation and puncture (CLP)-induced septic mice.
|
-
- HY-N9312
-
-
- HY-105939
-
|
Isofezolac
LM 22070
|
PGE synthase
|
Inflammation/Immunology
|
|
Isofezolac (LM 22070) is a non-steroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin-synthetase. Isofezolac anti-inflammatory, and antipyretic properties.
|
-
- HY-N7700
-
-
- HY-P99775
-
|
Placulumab
ART621; CEP-37247; PN0621
|
TNF Receptor
|
Inflammation/Immunology
|
|
Placulumab (ART621) is an anti-TNF α monoclonal antibody. Placulumab has anti-inflammatory activity and has potential applications in inflammatory diseases such as arthritis.
|
-
- HY-B1137
-
|
Ramifenazone
Isopropylaminoantipyrine
|
Bacterial
|
Inflammation/Immunology
|
|
Ramifenazone (Isopropylaminoantipyrine) is a pyrazole derivative and acts as a non-steroidal anti-inflammatory agent (NSAID). Ramifenazone has analgesic, antipyretic, anti-inflammatory and antimicrobial activities.
|
-
- HY-17361S
-
|
Etofenamate-d4
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
|
|
Etofenamate-d4 is the deuterium labeled Etofenamate. Etofenamate, a non-steroid anti-inflammatory agent (NSAID) and a non-selective COX inhibitor, possesses analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties. Etofenamate is used in the research for osteoarthritis, arthritis and other inflammatory diseases[1][2][3].
|
-
- HY-N2083
-
|
Handelin
|
NF-κB
|
Inflammation/Immunology
|
|
Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating NF-κB signaling and pro-inflammatory cytokine production.
|
-
- HY-17488
-
|
Morniflumate
UP 164
|
Others
|
Inflammation/Immunology
|
|
Morniflumate (UP 164) is an orally active nonsteroidal anti-inflammatory agent. Morniflumate can be used in the study of inflammatory diseases such as osteoarthritis, painful musculoskeletal disorders and soft tissue inflammation.
|
-
- HY-N0474
-
-
- HY-103595
-
|
Epirizole
Mepirizole; DA-398
|
Others
|
Inflammation/Immunology
|
|
Epirizole (Mepirizole) is an orally active NSAID (nonsteroidal anti-inflammatory agent). Epirizole shows anti-inflammatory activity, and can be used in chronic rheumatoid arthritis research.
|
-
- HY-112809
-
|
GSK2646264
|
Syk
Src
LRRK2
GSK-3
JAK
VEGFR
Aurora Kinase
|
Inflammation/Immunology
|
|
GSK2646264 (Compound 44) is a potent and selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.1. GSK2646264 also inhibits other kinases with pIC50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 against LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B and Aurora A, respectively. GSK2646264 is penetrable into the epidermis and dermis of the skin.
|
-
- HY-B2113
-
-
- HY-101751
-
-
- HY-U00081
-
-
- HY-B0634
-
|
Aceclofenac
|
COX
|
Inflammation/Immunology
|
|
Aceclofenac is an orally active nonsteroidal anti-inflammatory agent (NSAID), with analgesic and anti-inflammatory properties. Aceclofenac is used for the research of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis.
|
-
- HY-134116
-
|
Isoflupredone acetate
|
Others
|
Infection
Inflammation/Immunology
|
|
Isoflupredone acetate is a corticosteroids with anti-inflammatory activity. Isoflupredone acetate can be used for research ketosis, musculoskeletal disorders, hypersensitivity, infections, inflammatory diseases in cows, horse, pigs, et al..
|
-
- HY-148224
-
|
Pifoxime
|
COX
|
Inflammation/Immunology
|
|
Pifoxime is a COX-1/2 inhibitor, a non-steroidal anti-inflammatory agent (NSAID). Pifoxime shows anti-inflammatory activity, and can be used in neuropsychiatric research.
|
-
- HY-106215
-
|
Etiprednol dicloacetate
BNP 166; Etiprednol dichloroacetate
|
Others
|
Inflammation/Immunology
|
|
Etiprednol dicloacetate (BNP 166) is an anti-inflammatory agent. Etiprednol dicloacetate inhibits eosinophil accumulation. Etiprednol dicloacetate can be used in the research of inflammatory airway diseases, such as asthma.
|
-
- HY-129060
-
|
Flutrimazole
|
Fungal
|
Infection
|
|
Flutrimazole is an imidazole antifungal with dual anti-inflammatory and antifungal activity. Flutrimazole shows scarce transdermal penetration. Flutrimazole has the advantageous in the research of topical fungal infections with an inflammatory component.
|
-
- HY-100146
-
-
- HY-111392
-
-
- HY-B1203
-
-
- HY-100286
-
-
- HY-U00100
-
-
- HY-B1047
-
-
- HY-144773A
-
-
- HY-W015820
-
|
Phthalide
|
Bacterial
|
Inflammation/Immunology
|
|
Phthalide is a promising chemical scaffold with a potent anti-inflammatory efficacy. Phthalide can be used to synthesize a variety of phthalide derivatives including anti-inflammatory agent, antimicrobial, antioxidant.
|
-
- HY-23119
-
-
- HY-101655
-
|
COX-2-IN-2
|
COX
|
Inflammation/Immunology
|
|
COX-2-IN-2 is a selective and inducible COX2 inhibitor with an IC50 of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.
|
-
- HY-119684
-
|
Maresin 2
|
Others
|
Inflammation/Immunology
|
|
Maresin 2 is an anti-inflammatory and pro-resolving mediator from human macrophages. Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages.
|
-
- HY-B0619
-
|
Zaltoprofen
CN100
|
COX
|
Inflammation/Immunology
|
|
Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain.
|
-
- HY-109098
-
-
- HY-17476
-
-
- HY-B0288B
-
-
- HY-N2988A
-
-
- HY-B0288A
-
-
- HY-N10276
-
-
- HY-14937
-
-
- HY-N3587
-
-
- HY-W050088
-
|
Isoxepac
HP 549
|
Others
|
Inflammation/Immunology
|
|
Isoxepac (HP 549) is a nonsteroidal anti-inflammatory agent (NSAID) with anti-inflammatory, analgesic and antipyretic activity. Isoxepac has been studied in rat, rabbit, dog, rhesus monkey, etc.
|
-
- HY-144237
-
|
BRP-201
|
PGE synthase
|
Inflammation/Immunology
|
|
Brp-201 is considered as a promising therapeutic target for the next generation of anti-inflammatory drugs in the research of inflammatory diseases. It is a new, effective and selective inhibitor of mPGES-1 with an IC50 value of 0.42 μM.
|
-
- HY-152670
-
|
JC2-11
|
NOD-like Receptor (NLR)
AIM2
|
Inflammation/Immunology
|
|
JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1.
|
-
- HY-144238
-
|
mPGES-1-IN-1
|
PGE synthase
|
Inflammation/Immunology
|
|
MPGES-1 is considered as a promising therapeutic target of the next generation anti-inflammatory drugs in the research of inflammatory diseases. The < b > IC < sub > 50 < / sub > < / b > value of mPGES-1-IN-1 is 0.03 μ M。
|
-
- HY-106579
-
|
Tiaprofenic acid
|
COX
|
Inflammation/Immunology
|
|
Tiaprofenic acid is an orally active nonsteroidal anti-inflammatory agent (NSAID) with anti-inflammatory and analgesic potency. Tiaprofenic acid inhibits prostaglandin synthesis by suppressing cyclo-oxygenase (COX). Tiaprofenic acid can be used in the treatment of rheumatic diseases.
|
-
- HY-128695
-
-
- HY-13571
-
-
- HY-U00278
-
|
Deloxolone
(3β,20β)-3-(3-Carboxy-1-oxopropoxy)olean-9(11)-en-29-oic acid
|
Others
|
Inflammation/Immunology
|
|
Deloxolone has the potential for inflammatory, ischemic and proliferative diseases treatment.
|
-
- HY-U00350
-
-
- HY-N0213
-
-
- HY-W011954
-
-
- HY-B0645
-
-
- HY-U00043
-
-
- HY-B1383
-
-
- HY-N2030
-
-
- HY-17485
-
|
Alminoprofen
EB-382
|
Phospholipase
COX
|
Inflammation/Immunology
|
|
Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory agent (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A2 (sPLA2) and COX-2.
|
-
- HY-106628
-
|
Sudoxicam
|
COX
|
Inflammation/Immunology
|
|
Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory drug (NSAID) from the enol-carboxamide class. Sudoxicam has potent anti-inflammatory, anti-edema and antipyretic activity.
|
-
- HY-B1137S
-
-
- HY-116015
-
-
- HY-N1965
-
|
Gaultherin
|
Others
|
Inflammation/Immunology
|
|
Gaultherin, a natural salicylate derivative, is isolated from Gaultheria yunnanensis. Gaultherin is a non-steroidal anti-inflammatory drug (NSAID). Gaultherin has analgesic and anti-inflammatory effects and lack gastric ulcerogenic effect compared to Aspirin.
|
-
- HY-17629
-
|
Dapansutrile
OLT1177
|
NOD-like Receptor (NLR)
|
Inflammation/Immunology
|
|
Dapansutrile (OLT1177) is a potent, orally active and selective NLRP3 inflammasome inhibitor. Dapansutrile has anti-inflammatory activity and decreases immune factor levels. Dapansutrile can be used for research of inflammatory diseases.
|
-
- HY-N0110
-
-
- HY-N0110A
-
-
- HY-128583
-
|
G150
|
Cyclic GMP-AMP Synthase
|
Inflammation/Immunology
|
|
G150 is a highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with an IC50 of 10.2 nM. G150 represses dsDNA-triggered interferon expression, and G150 can be used for the research of inflammatory.
|
-
- HY-115502A
-
|
BCI hydrochloride
(E)-BCI hydrochloride
|
Phosphatase
|
Inflammation/Immunology
|
|
BCI ((E)-BCI) hydrochloride is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI hydrochloride shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI hydrochloride can be used in inflammatory disease research.
|
-
- HY-109011
-
|
Rosiptor
AQX-1125
|
Phosphatase
|
Cancer
|
|
Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro.
|
-
- HY-N8435
-
-
- HY-111950
-
|
(-)-Ibuprofenamide
(R)-Ibuprofenamide
|
Others
|
Inflammation/Immunology
|
|
(-)-Ibuprofenamide is an amide proagent of Ibuprofen with anti-inflammatory activity. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.
|
-
- HY-B0634S
-
|
Aceclofenac-d4
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
|
|
Aceclofenac-d4 is the deuterium labeled Aceclofenac. Aceclofenac is an orally active nonsteroidal anti-inflammatory agent (NSAID), with analgesic and anti-inflammatory properties. Aceclofenac is used for the research of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis[1][2].
|
-
- HY-118752
-
|
Fentiazac
|
Others
|
Inflammation/Immunology
|
|
Fentiazac, alkanoic acid derivative, is an orally active non-steroidal anti-inflammatory agent, with analgesic, antipyretic and platelet anti-aggregation activity. Fentiazac can be used to research inflammatory diseases such as rheumatoid arthritis, osteoarthritis and tendinitis.
|
-
- HY-115502
-
|
BCI
(E)-BCI
|
Phosphatase
|
Inflammation/Immunology
|
|
BCI ((E)-BCI) is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI can be used in inflammatory disease research.
|
-
- HY-17463
-
-
- HY-B0248
-
-
- HY-N0875
-
-
- HY-U00298
-
-
- HY-N4312
-
-
- HY-W173309
-
-
- HY-N0725
-
-
- HY-B1900
-
-
- HY-130365
-
-
- HY-103025
-
|
Methylprednisolone aceponate
ZK 91588; MPA
|
Glucocorticoid Receptor
|
Inflammation/Immunology
|
|
Methylprednisolone aceponate (ZK 91588) is a glucocorticoid and anti-inflammatory agent with weak systemic effects. Methylprednisolone aceponate is a selective glucocorticoid receptor Ligand.Methylprednisolone aceponate can be used for research of eczema and other inflammatory skin disorders.
|
-
- HY-N0110B
-
-
- HY-13545
-
|
ABT-510
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
ABT-510 is an anti-angiogenic TSP peptide (Thrombospondin-1 analogue) that induces apoptosis and inhibits ovarian tumour growth in an orthotopic, syngeneic model of epithelial ovarian cancer. ABT-510 also reduces angiogenesis and inflammatory responses in a murine model of inflammatory bowel disease. ABT-510 can be used in studies of cancer (particularly epithelial ovarian cancer) and inflammatory bowel disease (IBD).
|
-
- HY-P99256
-
|
Tildrakizumab
SCH 900222; MK 3222; Anti-Human IL23 Recombinant Antibody
|
Interleukin Related
|
Inflammation/Immunology
|
|
Tildrakizumab (SCH 900222) is a humanized anti-IL-23 (p19 subunit) monoclonal antibody. IL-23 is a critical cytokine to maintain the Th17 cell phenotype. Tildrakizumab has high-affinity for single-chain IL-23 (Kd: 136 pM). Tildrakizumab is effective against moderate to severe plaque psoriasis.
|
-
- HY-144168A
-
-
- HY-144277
-
-
- HY-101251
-
-
- HY-N7645
-
|
Prunetrin
Trifoside; Prunetin 4′-O-β-D-glucopyranoside
|
Others
|
Others
|
|
Prunetrin (Trifoside) is a soflavonoid found in above-ground and below-ground organs of red clover.
|
-
- HY-114180
-
|
RU.521
RU320521
|
Cyclic GMP-AMP Synthase
|
Metabolic Disease
|
|
RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS).
|
-
- HY-144168
-
-
- HY-147817
-
-
- HY-N7887
-
-
- HY-106583
-
|
Piroxicam cinnamate
Cinnoxicam; SPA-S-510; Sinartol
|
COX
|
Inflammation/Immunology
|
|
Piroxicam cinnamate (Cinnoxicam) is a cyclooxygenase (COX) inhibitor, with anti-inflammatory activity. Piroxicam cinnamate is stable under gastric conditions, can be used for inflammatory-degenerative osteoarticular diseases, rheumatic disorders, and varicocele (VC) associated oligoasthenospermia research.
|
-
- HY-17486
-
-
- HY-N5116
-
-
- HY-148791
-
-
- HY-N0212
-
|
Peimine
Verticine; Dihydroisoimperialine
|
Others
|
Inflammation/Immunology
|
|
Peimine(Dihydroisoimperialine; Verticine) is a natural compound with good anti-inflammatory effects in vivo.
|
-
- HY-103672
-
-
- HY-N6941
-
-
- HY-N0741A
-
-
- HY-N2123
-
-
- HY-N0741
-
-
- HY-U00169
-
-
- HY-B0270
-
-
- HY-N1101
-
-
- HY-107939
-
-
- HY-148187
-
-
- HY-151435
-
|
CCR6 antagonist 1
|
CCR
|
Inflammation/Immunology
|
|
CCR6 antagonist 1 is a CCR6 antagonist that inhibits the CCL20/CCR6 axis. CCR6 antagonist 1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs).
|
-
- HY-N7012
-
|
7,3',4'-Tri-O-methylluteolin
5-Hydroxy-3',4',7-trimethoxyflavone
|
TNF Receptor
Interleukin Related
COX
|
Inflammation/Immunology
|
|
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2.
|
-
- HY-B0619S1
-
|
Zaltoprofen-13C,d3
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
|
|
Zaltoprofen- 13C,d3 is the 13C- and deuterium labeled Zaltoprofen. Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain[1][2][3].
|
-
- HY-150060
-
|
PDE4-IN-11
|
Phosphodiesterase (PDE)
|
Inflammation/Immunology
|
|
PDE4-IN-11 is an inhibitor of phosphodiesterase isoenzyme 4 (PDE4). PDE4-IN-11 displays highly effective bronchodilatory and anti-inflammatory properties, can be used for obstructive or inflammatory airway diseases research.
|
-
- HY-152034
-
|
STING-IN-5
|
STING
|
Inflammation/Immunology
|
|
STING-IN-5 is a potent STING inhibitor, inhibiting LPS-induced NO synthesis in macrophages with an IC50 value of 1.15 μM. STING-IN-5 inhibits the inflammatory response. STING-IN-5 can be used to research anti-inflammatory diseases and sepsis.
|
-
- HY-100977
-
-
- HY-109182
-
-
- HY-N0559
-
-
- HY-14164A
-
-
- HY-P1539
-
-
- HY-N10125
-
-
- HY-N0181
-
-
- HY-N0056
-
-
- HY-N3472
-
-
- HY-17484
-
-
- HY-B1013
-
-
- HY-N10210
-
-
- HY-N0813
-
-
- HY-U00083
-
-
- HY-14579
-
-
- HY-N2352A
-
-
- HY-N2271
-
-
- HY-103385
-
|
NCX4040
NO-Aspirin
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
NCX4040 (NO-Aspirin), a non-steroidal anti-inflammatory drug (NSAID), is a nitric oxide (NO) releasing form of Aspirin. NCX4040 induces apoptosis in PC3 metastatic prostate cancer cells. NCX4040 has anti-inflammatory and anti-cancer effects.
|
-
- HY-131502
-
|
Taspine
|
P2X Receptor
|
Inflammation/Immunology
|
|
Taspine is a natural product with anti-inflammatory activity. Taspine suppresses P2X4 receptor activity via PI3K inhibition. Taspine inhibits pro-inflammatory signalling via inhibition of P2X4 receptors in macrophage.
|
-
- HY-N7176
-
|
Kaempferol 3-O-β-D-glucuronide
Kaempferol-3-glucuronide; Kaempferol-3-O-glucuronide
|
Interleukin Related
|
Inflammation/Immunology
|
|
Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide), one conjugated kaempferol metabolite, has anti-inflammatory effect. Kaempferol 3-O-β-D-glucuronide significantly inhibits various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. Kaempferol 3-O-β-D-glucuronide upregulates the secretion of anti-inflammatory cytokine IL-10.
|
-
- HY-B0641
-
-
- HY-122267A
-
-
- HY-B0482
-
|
Acemetacin
TVX 1322
|
COX
|
Inflammation/Immunology
|
|
Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
|
-
- HY-N2516
-
-
- HY-17481
-
-
- HY-N0007
-
-
- HY-N7700A
-
-
- HY-B1179
-
-
- HY-N8534
-
-
- HY-N3891
-
-
- HY-14857
-
-
- HY-N8197
-
-
- HY-N2854
-
-
- HY-B1104
-
-
- HY-108281
-
-
- HY-107208
-
-
- HY-N10120
-
-
- HY-N2151
-
-
- HY-N9400
-
-
- HY-111354
-
-
- HY-124670
-
-
- HY-101581
-
|
Bucloxic acid
804CB; Bucloxonic acid; Esfar
|
Others
|
Inflammation/Immunology
|
|
Bucloxic acid is an anti-inflammatory pyrrazole derivative. Bucloxic acid can be used in the treatment of chronic glomerular nephropathies.
|
-
- HY-14916
-
-
- HY-U00048
-
-
- HY-N2152
-
-
- HY-N2154
-
-
- HY-P99336
-
|
Enlimomab
BI-RR 0001; Anti-Human IL6 Recombinant Antibody
|
Integrin
|
Inflammation/Immunology
Neurological Disease
|
|
Enlimomab (BI-RR 0001), a murine IgG2a monoclonal antibody to the human ICAM-1, inhibits leukocyte adhesion to the vascular endothelium, thereby decreasing leukocyte extravasation and inflammatory tissue injury. Enlimomab has anti-inflammatory effects, and can be used for stroke research .
|
-
- HY-17463S
-
|
Prednisolone-d8
|
Glucocorticoid Receptor
Endogenous Metabolite
|
Endocrinology
|
|
Prednisolone-d8 is the deuterium labeled Prednisolone. Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research[1][2].
|
-
- HY-148591
-
|
GSK761
|
Epigenetic Reader Domain
|
Inflammation/Immunology
|
|
GSK761 is a selective inhibitor of speckled 140 kDa (SP140) with an IC50 value of 77.79 nM. GSK761 reduces monocyte-to-inflammatory macrophage differentiation and lipopolysaccharide (LPS)-induced inflammatory activation. GSK761 induces the production of CD206 + regulatory macrophages by inhibiting SP140.
|
-
- HY-120824
-
|
Mofezolac
|
COX
|
Inflammation/Immunology
|
|
Mofezolac, a non-steroidal anti-inflammatory drug (NSAID), is a selective, reversible and orally active COX-1 inhibitor with an IC50 of 1.44 nM. Mofezolac shows weak inhibitory activity on COX-2 (IC50 of 447 nM). Mofezolac can relieve pain and has anti-inflammatory activities.
|
-
- HY-19384
-
|
Enflicoxib
E 6087
|
COX
|
Inflammation/Immunology
|
|
Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2). Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models.
|
-
- HY-N3125
-
-
- HY-W173220
-
-
- HY-N0101
-
-
- HY-B1203S
-
-
- HY-B1079
-
-
- HY-N8038
-
|
Isoanthricin
(Rac)-Deoxypodophyllotoxin
|
Others
|
Others
|
|
Isoanthricin ((Rac)-Deoxypodophyllotoxin) is the racemate of Deoxypodophyllotoxin. Deoxypodophyllotoxin is a potent antitumor and anti-inflammatory agent.
|
-
- HY-N10112
-
-
- HY-N8149
-
-
- HY-N0272
-
-
- HY-B0485
-
-
- HY-150002
-
-
- HY-B1203S1
-
|
Fludrocortisone-d2
9α-Fludrocortisone-d2; 9α-Fluorcortisol-d2
|
Mineralocorticoid Receptor
|
|
|
Fludrocortisone-d2 is the deuterium labeled Fludrocortisone. Fludrocortisone, a synthetic mineralocorticoid with anti-inflammatory activity.
|
-
- HY-N10746
-
-
- HY-N4290
-
-
- HY-N6804
-
-
- HY-117960
-
-
- HY-U00103
-
-
- HY-N10747
-
-
- HY-U00331
-
-
- HY-105198
-
-
- HY-U00282
-
-
- HY-B0878
-
|
Halobetasol (propionate)
BMY-30056; CGP-14458; Ulobetasol propionate
|
Others
|
Others
|
|
Halobetasol propionate is a synthetic corticosteroid for topical dermatological use; exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties.
|
-
- HY-N9375
-
-
- HY-105283
-
-
- HY-N7976
-
-
- HY-N2052
-
-
- HY-N3295
-
-
- HY-N6948
-
-
- HY-101831
-
-
- HY-N7903
-
-
- HY-126390
-
|
(E/Z)-BCI
NSC 150117
|
Phosphatase
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
(E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway.
|
-
- HY-117469
-
|
Triptohypol C
|
Others
|
Inflammation/Immunology
|
|
Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an Kd value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1.
|
-
- HY-12521
-
|
GSK-5498A
|
CRAC Channel
|
Inflammation/Immunology
|
|
GSK-5498A is a selective CARC channel inhibitor (IC50: 1 μM). GSK-5498A inhibits mediators release from mast cells and pro-inflammatory cytokines release from T cells. GSK-5498A can be used in the research of inflammatory disorders.
|
-
- HY-N0314
-
-
- HY-10582
-
|
Flurbiprofen
dl-Flurbiprofen
|
COX
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer.
|
-
- HY-145854
-
|
GA-O-06
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
GA-O-06, a 18β-Glycyrrhetinic acid derivative, is a potent antimicrobial and anti-inflammatory agent. GA-O-06 exerts anti-inflammation through the inhibition of NO, pro-inflammatory cytokines and chemokines. GA-O-06 displays a high antimicrobial activity against Gram-positive bacteria.
|
-
- HY-N2855
-
|
Alphitolic acid
Aophitolic acid
|
Apoptosis
Autophagy
TNF Receptor
Akt
NF-κB
|
Cancer
Inflammation/Immunology
|
|
Alphitolic acid (Aophitolic acid) is an anti-inflammatory triterpene could found in quercus aliena. Alphitolic acid blocks Akt–NF-κB signaling to induce apoptosis. Alphitolic acid induces autophagy. Alphitolic acid has anti-inflammatory activity and down-regulates the NO and TNF-α production. Alphitolic acid can be used for cancer and inflammation research.
|
-
- HY-145853
-
|
GA-O-02
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
GA-O-02, a 18β-Glycyrrhetinic acid derivative, is a potent antimicrobial and anti-inflammatory agent. GA-O-02 exerts anti-inflammation through the inhibition of NO, pro-inflammatory cytokines and chemokines. GA-O-02 displays a high antimicrobial activity against Gram-positive bacteria.
|
-
- HY-146032
-
-
- HY-135119
-
|
Salmeterol-D3
|
Adrenergic Receptor
|
Endocrinology
Inflammation/Immunology
|
|
Salmeterol-d3 is a deuterium labeled Salmeterol. Salmeterol is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively[1].
|
-
- HY-108323
-
|
CCR2 antagonist 4
Teijin compound 1
|
CCR
|
Inflammation/Immunology
|
|
CCR2 antagonist 4 (Teijin compound 1) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 potently inhibits MCP-1-induced chemotaxis with an IC50 of 24 nM.
|
-
- HY-120689
-
-
- HY-103362
-
|
CCR2 antagonist 4 hydrochloride
Teijin compound 1 hydrochloride
|
CCR
|
Inflammation/Immunology
|
|
CCR2 antagonist 4 hydrochloride (Teijin compound 1 hydrochloride) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 hydrochloride potently inhibits MCP-1-induced chemotaxis with an IC50 of 24 nM.
|
-
- HY-122586
-
|
BRD6989
|
CDK
Interleukin Related
|
Inflammation/Immunology
|
|
BRD6989, an analog of the natural product cortistatin A (dCA), inhibits CDK8 and upregulates IL-10. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes.
|
-
- HY-107589A
-
|
BIO5192 hydrate
|
Integrin
|
Inflammation/Immunology
|
|
BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 hydrate selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 hydrate results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels.
|
-
- HY-14302
-
-
- HY-17453
-
-
- HY-107589
-
|
BIO5192
|
Integrin
|
Inflammation/Immunology
|
|
BIO5192 is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels.
|
-
- HY-135373
-
-
- HY-120823
-
-
- HY-116099
-
-
- HY-B1214
-
-
- HY-N0759
-
-
- HY-N6039
-
-
- HY-B0494
-
-
- HY-U00352
-
-
- HY-N3017
-
-
- HY-Y1362
-
-
- HY-N1198
-
-
- HY-N6827
-
-
- HY-N2965
-
-
- HY-17509
-
-
- HY-76225
-
|
Ammonium glycyrrhizinate
Monoammonium glycyrrhizinate; Glycyrrhizic acid ammonium salt; Ammonium glycyrrhizate
|
Others
|
Inflammation/Immunology
|
|
Ammonium glycyrrhizinate (Monoammonium glycyrrhizinate) has various pharmacological actions such as anti-inflammatory, antiallergic, antigastriculcer, and antihepatitis activities.
|
-
- HY-N2441
-
-
- HY-131118
-
-
- HY-W505771
-
-
- HY-125131
-
-
- HY-N3544
-
-
- HY-147247
-
-
- HY-N0423
-
-
- HY-121235
-
-
- HY-B0808S
-
|
Oxaprozin-d4
Wy-21743-d4
|
COX
|
Others
|
|
Oxaprozin-d4 is the deuterium labeled Oxaprozin, which is a non-steroidal anti-inflammatory agent (NSAID).
|
-
- HY-124240
-
-
- HY-N2437
-
-
- HY-B0775
-
-
- HY-B1087
-
-
- HY-101482
-
-
- HY-N2302
-
-
- HY-139567
-
-
- HY-N0370
-
-
- HY-N0408
-
|
Picroside II
|
NF-κB
Reactive Oxygen Species
Apoptosis
Influenza Virus
|
Cancer
Infection
Inflammation/Immunology
Neurological Disease
|
|
Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities.
picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways.
Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood-brain barrier (BBB) after cerebral ischemia-reperfusion (CI/R) injury. Picroside II has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.
|
-
- HY-Y0189
-
|
Methyl Salicylate
Salicylic acid methyl ester
|
COX
|
Inflammation/Immunology
|
|
Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products. A systemic acquired resistance (SAR) signal in tobacco. A topical nonsteroidal anti-inflammatory agent (NSAID). Methyl salicylate lactoside is a COX inhibitor.
|
-
- HY-109567
-
|
Gemcabene
PD-72953
|
Others
|
Metabolic Disease
Inflammation/Immunology
|
|
Gemcabene (PD-72953), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity.
|
-
- HY-N0313
-
|
Euphol
|
Endogenous Metabolite
MAGL
|
Inflammation/Immunology
|
|
Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain.
|
-
- HY-147404
-
-
- HY-N2035
-
-
- HY-N1981
-
-
- HY-N9834
-
-
- HY-N2393
-
-
- HY-N0719
-
-
- HY-B0625
-
-
- HY-N2114
-
-
- HY-13075
-
-
- HY-N1089
-
-
- HY-119517
-
-
- HY-N7083
-
|
Citral
Citral, mixture of cis and trans
|
Others
|
Inflammation/Immunology
Cancer
|
|
Citral is a monoterpene found in Cymbopogon citratus essential oil, with antihyperalgesic, anti-nociceptive and anti-inflammatory effects.
|
-
- HY-14398
-
-
- HY-139703
-
-
- HY-104015
-
-
- HY-N0576
-
-
- HY-148798A
-
-
- HY-130046
-
-
- HY-B0367
-
-
- HY-B1832
-
-
- HY-N0228
-
-
- HY-101481
-
-
- HY-N5010
-
-
- HY-N9388
-
-
- HY-U00063
-
-
- HY-14938
-
-
- HY-132892
-
-
- HY-128703
-
-
- HY-P1572
-
-
- HY-104025
-
-
- HY-N2714
-
-
- HY-N5025
-
|
Bullatine A
|
P2X Receptor
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A is a potent P2X7 antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed.
|
-
- HY-147748
-
|
COX-2-IN-17
|
COX
|
Inflammation/Immunology
|
|
COX-2-IN-17 (compound 10) is a potent and BBB-penetrated COX-2 (cyclooxygenase-2) inhibitor, with an IC50 of 0.02 μM. COX-2-IN-17 shows anti-inflammatory and analgesic activities. COX-2-IN-17 attenuates hyperalgesia in the neurogenic phase as well as the inflammatory phase.
|
-
- HY-105028
-
|
Tenidap
CP-66248
|
COX
|
Inflammation/Immunology
|
|
Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties. Tenidap is also a specific SLC26A3 inhibitor.
|
-
- HY-N0831
-
|
Jaceosidin
|
Bcl-2 Family
COX
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression. Jaceosidin exhibits anti-cancer, anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation.
|
-
- HY-P2320
-
|
IDR-1
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
IDR-1 is an antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria. IDR-1 counters infection by selective modulation of innate immunity without obvious toxicities. IDR-1 has anti-inflammatory and anti-infective properties, enhances the levels of monocyte chemokines, and attenuates pro-inflammatory cytokine release.
|
-
- HY-109567A
-
|
Gemcabene calcium
PD-72953 calcium
|
Others
|
Metabolic Disease
Inflammation/Immunology
|
|
Gemcabene calcium (PD-72953 calcium), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity.
|
-
- HY-120007
-
-
- HY-139710
-
-
- HY-146479
-
-
- HY-133159
-
-
- HY-N4137
-
-
- HY-114771
-
-
- HY-N4146
-
-
- HY-N0516
-
|
Casticin
Vitexicarpin
|
STAT
|
Inflammation/Immunology
|
|
Casticin is a methyoxylated flavonol isolated from Vitex rotundifolia, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3.
|
-
- HY-N2263
-
|
Skimmin
Umbelliferone glucoside
|
Others
|
Inflammation/Immunology
|
|
Skimmin (Umbelliferone glucoside) is a coumarin found in Hydrangea paniculata, inhibits immune complex deposition, with anti-inflammatory activity.
|
-
- HY-N2012
-
-
- HY-N0628
-
-
- HY-W008613
-
-
- HY-W013331
-
-
- HY-N1178
-
-
- HY-U00187
-
|
NCX1022
|
Others
|
Inflammation/Immunology
|
|
NCX1022 is an NO-releasing derivative of Hydrocortisone, which is the most widely used anti-inflammatory agent for the treatment of skin inflammation.
|
-
- HY-B1153A
-
-
- HY-N2053
-
-
- HY-15029S
-
-
- HY-122915
-
-
- HY-N0184A
-
-
- HY-139709
-
-
- HY-109082A
-
-
- HY-N0180
-
-
- HY-N2401
-
-
- HY-N5022
-
|
Evolitrine
7-Methoxydictamnine; Evolitrin
|
Others
|
Inflammation/Immunology
|
|
Evolitrine (7-Methoxydictamnine; Evolitrin) is isolated from Acronychia pedunculata and show anti-inflammatory and antifeedant activities.
|
-
- HY-115870
-
-
- HY-109082
-
|
Cevidoplenib
SKI-O-703
|
Syk
|
Inflammation/Immunology
|
|
Cevidoplenib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities.
|
-
- HY-N8091
-
|
Lehmannine
|
Bacterial
|
Cancer
Infection
|
|
Lehmannine is a quinolizidine bioalkaloid isolated from S. alopecuroides L, has antibacterial, anti-inflammatory and anti-tumor activities.
|
-
- HY-N1625
-
-
- HY-12384
-
|
Tenosal
|
Others
|
Inflammation/Immunology
|
|
Tenosal is a new compound obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid and displays anti-inflammatory, analgesic and antipyretic properties.
|
-
- HY-U00022
-
-
- HY-105808
-
-
- HY-N0246
-
-
- HY-108297
-
-
- HY-N2842
-
-
- HY-N9694
-
-
- HY-N2082
-
|
Isorhamnetin 3-O-galactoside
Cacticin
|
Others
|
Inflammation/Immunology
Cardiovascular Disease
|
|
Isorhamnetin 3-O-galactoside (Cacticin), a flavonoid glycoside isolated from Artemisia capillaris Thunberg, which ameliorates CCl4-induced hepatic damage by enhancing the anti-oxidative defense system and reducing the inflammatory signaling pathways. Isorhamnetin 3-O-galactoside (Cacticin) has antithrombotic and anti-inflammatory activities.
|
-
- HY-14648
-
-
- HY-10582S
-
|
Flurbiprofen-d3
dl-Flurbiprofen-d3
|
COX
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Flurbiprofen-d3 is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].
|
-
- HY-10582S1
-
|
Flurbiprofen-d5
dl-Flurbiprofen-d5
|
COX
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Flurbiprofen-d5 is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].
|
-
- HY-147697
-
-
- HY-N6246
-
|
Asperulosidic Acid
|
NF-κB
ERK
|
Cancer
Inflammation/Immunology
|
|
Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities.
ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways.
|
-
- HY-Y0038
-
|
2-Bromo-6-methoxynaphthalene
|
Trk Receptor
|
Cancer
|
|
2-Bromo-6-methoxynaphthalene is an active intermediate in the production of anti-inflammatory agents like Naproxen and Nabumetone by Heck reaction. 2-Bromo-6-methoxynaphthalene has potential anti-inflammatory properties and Tyrosine-protein inhibitor properties. 2-Bromo-6-methoxynaphthalene can be used for the research of cancer.
|
-
- HY-N0512
-
|
Loganin
Loganoside
|
Apoptosis
|
Cancer
|
|
Loganin, a major iridoid glycoside obtained from Corni fructus, has been shown to have anti-inflammatory and anti-shock effects.
|
-
- HY-15097
-
-
- HY-N0625A
-
-
- HY-133588
-
-
- HY-N7937
-
-
- HY-116442
-
|
Azapropazone
|
Others
|
Inflammation/Immunology
|
|
Azapropazone is a nonsteroidal anti-inflammatory agent (NSAID). Azapropazone can be used for the research of rheumatoid arthritis and other rheumatoid conditions.
|
-
- HY-B1015
-
|
Etosalamide
Ethosalamide
|
Others
|
Inflammation/Immunology
|
|
Etosalamide (Ethosalamide) is an antipyretic and analgesic agent. Etosalamide has anti-inflammatory activity and can be used for allergic disease research.
|
-
- HY-13571S
-
-
- HY-N7036
-
-
- HY-N0472
-
-
- HY-108528
-
-
- HY-N4006
-
-
- HY-N0114
-
|
Evodiamine
(+)-Evodiamine; d-Evodiamine
|
Others
|
Cancer
|
|
Evodiamine is an alkaloid isolated from the fruit of Evodia rutaecarpa Bentham with diverse biological activities including anti-inflammatory, anti-obesity, and antitumor.
|
-
- HY-P0206
-
-
- HY-N2488
-
-
- HY-139578
-
-
- HY-121711
-
-
- HY-B0493
-
-
- HY-N0891
-
|
Tubeimoside II
Tubeimoside-B
|
Others
|
Cancer
|
|
Tubeimoside II(Tubeimoside-B) is a natural analogue of oleanane type of triterpenoid saponin; show anti-inflammatory, antitumor, and antitumor-promoting effects.
|
-
- HY-N0028
-
-
- HY-N7694
-
-
- HY-135658
-
-
- HY-107456
-
-
- HY-N2542
-
-
- HY-B1153
-
|
Glafenine
Glafenin
|
Others
|
Inflammation/Immunology
|
|
Glafenine is a non-steroidal anti-inflammatory drug (NSAID), is a non-narcotic analgesic agent, widely used for the treatment of pains of various origins.
|
-
- HY-N7924
-
-
- HY-N0362
-
-
- HY-B0729
-
|
Polaprezinc
Zinc L-carnosine
|
Others
|
Inflammation/Immunology
|
|
Polaprezinc is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities.
|
-
- HY-N1037
-
-
- HY-N0661
-
-
- HY-N2604
-
-
- HY-A0273
-
|
Propyphenazone
4-Isopropylantipyrine; Isopropylphenazone
|
COX
|
Inflammation/Immunology
|
|
Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.
|
-
- HY-W031757
-
-
- HY-N0400
-
-
- HY-U00382
-
-
- HY-121292
-
-
- HY-148798
-
|
Rovadicitinib
|
JAK
|
Cancer
|
|
Rovadicitinib is a Janus kinase (JAK) inhibitor with an IC50 value <20 nM. Rovadicitinib also exhibits anti-inflammatory activity.
|
-
- HY-N1408
-
-
- HY-78131B
-
-
- HY-N0271
-
-
- HY-14648A
-
-
- HY-17474S
-
|
Parecoxib-d3
SC 69124-d3
|
Isotope-Labeled Compounds
COX
|
Cancer
Inflammation/Immunology
|
|
Parecoxib-d3 is the deuterium labeled Parecoxib. Parecoxib (SC 69124) is a highly selective?and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.
|
-
- HY-151252
-
|
NIC-0102
|
Proteasome
NOD-like Receptor (NLR)
|
Inflammation/Immunology
|
|
NIC-0102 is an orally active proteasome inhibitor (pIC50=7.55) that specifically inhibits NLRP3 inflammatory vesicle activation. NIC-0102 shows potent anti-inflammatory effects in a model of dextran sulfate sodium (DSS)-induced ulcerative colitis. NIC-0102 also inhibits production of pro-IL-1β.
|
-
- HY-18263C
-
|
Elubrixin tosylate
SB-656933 tosylate
|
CXCR
Interleukin Related
|
Inflammation/Immunology
|
|
Elubrixin tosylate (SB-656933 tosylate) is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin tosylate inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin tosylate has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation.
|
-
- HY-12383
-
|
Pelubiprofen
|
COX
|
Inflammation/Immunology
Neurological Disease
|
|
Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects.
|
-
- HY-N10587
-
|
Catechin 7-O-β-D-glucopyranoside
|
Others
|
Inflammation/Immunology
|
|
Catechin 7-O-beta-D-glucopyranoside is an orally active natural product found in Ulmus davidiana and Paeonia obovata. Catechin 7-O-β-D-glucopyranoside shows antioxidant and anti-inflammatory activities, and attenuates mitochondrial dysfunction. Catechin 7-O-beta-D-glucopyranoside can be used in intestinal inflammatory disease research.
|
-
- HY-18263A
-
|
Elubrixin
SB-656933
|
CXCR
Interleukin Related
|
Inflammation/Immunology
|
|
Elubrixin (SB-656933) is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation.
|
-
- HY-107794
-
|
Clodronate disodium tetrahydrate
Disodium clodronate tetrahydrate
|
Others
|
Inflammation/Immunology
Neurological Disease
|
|
Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl - competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain.
|
-
- HY-10656
-
|
SB-657510
|
Urotensin Receptor
|
Inflammation/Immunology
|
|
SB-657510 is a selective urotensin II (UII) receptor (UT) antagonist. The Ki values are 61, 17, 30, 65 and 56 nM for human, monkey, cat, rat and mouse receptors, respectively. SB-657510 exerts anti-inflammatory effects by inhibiting UII-induced upregulation of inflammatory mediators such as adhesion molecules, cytokines, and tissue factor in human vascular endothelial cells.
|
-
- HY-113527
-
-
- HY-114519
-
-
- HY-108249
-
|
Tribenoside
|
Others
|
Inflammation/Immunology
|
|
Tribenoside is a vasoprotective agent, can be used for the research of hemorrhoids. Tribenoside has mild anti-inflammatory, analgesic, and wound healing properties.
|
-
- HY-N0763
-
|
Angelicin
Isopsoralen
|
Apoptosis
Virus Protease
|
Cancer
|
|
Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity.
|
-
- HY-N0924
-
|
(±)-Stylopine
Tetrahydrocoptisine
|
Parasite
|
Inflammation/Immunology
|
|
(±)-Stylopine (Tetrahydrocoptisine) is an alkaloid compound originally isolated from Corydalis tubers that exhibits anti-inflammatory and anti-parasitic activities.
|
-
- HY-132405S
-
-
- HY-N0476
-
|
Wilforlide A
Regelide; Abruslactone A
|
Others
|
Inflammation/Immunology
|
|
Wilforlide A is a bioactive triterpene isolated from Tripterygium wilfordii Hook f. Wilforlide A has anti-inflammatory and immune suppressive effects.
|
-
- HY-113442
-
-
- HY-15204
-
-
- HY-N0940
-
-
- HY-N7138
-
-
- HY-N10844
-
-
- HY-N0924A
-
-
- HY-76251
-
-
- HY-121323
-
-
- HY-105092
-
-
- HY-19217
-
-
- HY-N7697A
-
-
- HY-W050088S
-
-
- HY-N1433
-
-
- HY-B0580A
-
-
- HY-132807
-
-
- HY-105014
-
-
- HY-13609
-
-
- HY-121076
-
-
- HY-123763
-
|
MLN3126
|
CCR
|
Inflammation/Immunology
|
|
MLN3126 is an orally active and potent CCR9 antagonist. MLN3126 inhibits CCL25-induced calcium mobilization and chemotaxis of mouse primary thymocytes, wiht an IC50 value of 6.3 nM for calcium influx.
|
-
- HY-131064
-
|
RIPK3-IN-1
|
RIP kinase
|
Inflammation/Immunology
|
|
RIPK3-IN-1 is a RIPK3 type II DFG-out inhibitor with an IC50 of 9.1 nM. RIPK3-IN-1 inhibits RIPK1 and RIPK2 with IC50s of 5.5 and >10 μM. RIPK3-IN-1 is also a c-Met kinase inhibitor with an IC50 of 1.1 μM.
|
-
- HY-145990
-
|
FABPs ligand 6
MF6
|
FABP
|
Inflammation/Immunology
|
|
FABPs ligand 6 (MF6) is an FABP5 and FABP7 inhibitor with KD values of 874 nM and 20 nM, respectively. FABPs ligand 6 can be used for multiple sclerosis research.
|
-
- HY-144452
-
|
Immunoproteasome inhibitor 1
|
Proteasome
|
Cancer
|
|
Immunoproteasome inhibitor 1 is a potent, reversible, time-independent immunoproteasome and proteasome inhibitor (Kis of 1.18, 0.27, 1.91 μM in β5c, β1i, β5i submits, respectively). Immunoproteasome inhibitor 1 can be used for the research of certain neoplastic diseases.
|
-
- HY-N7038
-
|
Phytohemagglutinin
PHA-M
|
Others
|
Inflammation/Immunology
|
|
Phytohemagglutinin (PHA-M), the major seed lectin of the common bean, Phaseolus vulgaris, accumulates in the parenchyma cells of the cotyledons. Phytohemagglutinin is a T-cell activator. Stimulation of human mononuclear leukocytes by Phytohemagglutinin induces the expression of ChAT mRNA, and potentiated ACh synthesis.
|
-
- HY-151621
-
-
- HY-138542
-
-
- HY-15724A
-
|
Vercirnon sodium
GSK-1605786 sodium; CCX282-B sodium; Traficet-EN sodium
|
CCR
|
Inflammation/Immunology
Endocrinology
|
|
Vercirnon (GSK1605786A) sodium is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon sodium inhibits CCR9-mediated Ca 2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon sodium is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 µM for all). Vercirnon sodium is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively.
|
-
- HY-146456
-
|
A1AR antagonist 3
|
Adenosine Receptor
|
Neurological Disease
|
|
A1AR antagonist 3 (compound 13) is a selective adenosine 1 (A1) receptor antagonist with Kis of 9.69 nM and 0.529 nM for human A1 and rat A1, respectively. A1AR antagonist 3 can be used for researching neurological diseases.
|
-
- HY-107410
-
|
SC-26196
|
Others
|
Inflammation/Immunology
|
|
SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC50=0.2 µM in a rat liver microsomal assay). Antiinflammatory properties.
|
-
- HY-15724
-
|
Vercirnon
GSK-1605786; CCX282-B; Traficet-EN
|
CCR
|
Inflammation/Immunology
Endocrinology
|
|
Vercirnon (GSK1605786A) is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon inhibits CCR9-mediated Ca 2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 µM for all). Vercirnon is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively.
|
-
- HY-151100
-
|
GPR84 antagonist 3
|
GPR84
|
Inflammation/Immunology
|
|
GPR84 antagonist 3 (compound 42) is a potent GPR84 (G-protein-coupled receptor 84) antagonist. GPR84 antagonist 3 inhibits GTPγS, with a pIC50 of 8.28. GPR84 antagonist 3 has a favorable pharmacokinetic profile suitable.
|
-
- HY-17474AS
-
|
Parecoxib-d5 sodium
SC 69124A-d5
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
Cancer
|
|
Parecoxib-d5 (sodium) is the deuterium labeled Parecoxib sodium. Parecoxib Sodium (SC 69124A) is a highly selective?and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib Sodium can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo[1][2].
|
-
- HY-N2908
-
|
Atraric acid
Methyl atrarate
|
Androgen Receptor
NO Synthase
p38 MAPK
NF-κB
|
Cancer
Inflammation/Immunology
|
|
Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis of NO and cytokine, and suppress the MAPK-NFκB signaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases.
|
-
- HY-105028S
-
|
Tenidap-d3
CP-66248-d3
|
COX
|
Inflammation/Immunology
|
|
Tenidap-d3 is the deuterium labeled Tenidap. Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2]. Tenidap is also a specific SLC26A3 inhibitor[3].
|
-
- HY-123386
-
-
- HY-P1009
-
|
Z-YVAD-FMK
|
Caspase
|
Cancer
|
|
Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities.
|
-
- HY-N0263
-
|
Toosendanin
|
Others
|
Inflammation/Immunology
|
|
Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb et Zucc, possesses analgesic, insecticidal and anti-inflammatory activities.
|
-
- HY-N7931
-
-
- HY-N7643
-
-
- HY-N4231
-
-
- HY-121481
-
|
Cucurbitadienol
10α-Cucurbitadienol
|
Others
|
Inflammation/Immunology
|
|
Cucurbitadienol (10α-Cucurbitadienol) is a natural product that can be found in the seeds of Trichosanthes kirilowii. Cucurbitadienol exhibits anti-inflammatory effect.
|
-
- HY-N2909
-
|
Aurantiamide
|
Others
|
Inflammation/Immunology
|
|
Aurantiamide is an orally active constituent of Portulaca oleracea L and has various biological activities, including antioxidant, antiplatelet, anti-inflammatory, and antitumor activities.
|
-
- HY-B1893
-
-
- HY-B1026
-
-
- HY-137454
-
-
- HY-147811
-
-
- HY-B0214
-
-
- HY-B2191
-
|
Sodium gualenate
Guaiazulenesulfonate sodium
|
Others
|
Inflammation/Immunology
|
|
Sodium gualenate (Guaiazulenesulfonate sodium) is a hydrophilic derivative of guaiazulene with excellent anti-inflammatory and wound-healing effects mainly used for the treatment of duodenal ulcer, gastric ulcer and gastritis.
|
-
- HY-144773
-
-
- HY-N0007S
-
|
Bisdemethoxycurcumin-d8
Curcumin III-d8; Didemethoxycurcumin-d8
|
Apoptosis
Autophagy
|
Cancer
|
|
Bisdemethoxycurcumin-d8 is the deuterium labeled Bisdemethoxycurcumin. Bisdemethoxycurcumin(Curcumin III; Didemethoxycurcumin) is a natural derivative of curcumin with anti-inflammatory and anti-cancer activities.
|
-
- HY-U00366
-
-
- HY-N0570
-
-
- HY-N0748
-
-
- HY-103325
-
-
- HY-N6244
-
|
Isolindleyin
|
Tyrosinase
|
Inflammation/Immunology
|
|
Isolindleyin, a butyrophenone, is a tyrosinase inhibitor, with a Kd of 54.8 μM for human tyrosinase. Isolindleyin exhibits anti-inflammatory, analgesic and anti-melanogenic activities.
|
-
- HY-135301
-
-
- HY-P3466
-
-
- HY-N7993
-
-
- HY-N0006S1
-
|
Demethoxycurcumin-d4
Curcumin II-d4; Desmethoxycurcumin-d4; Monodemethoxycurcumin-d4
|
Bacterial
Autophagy
Apoptosis
|
Cancer
|
|
Demethoxycurcumin-d4 is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin (Curcumin II) is a major active curcuminoid; possess anti-inflammatory properties[1].
|
-
- HY-N10782
-
-
- HY-N3509
-
|
Hyponine E
(-)-Hyponine E
|
Others
|
Inflammation/Immunology
|
|
Hyponine E, a macrocyclic sesquiterpene pyridine alkaloid that could be isolated from from Tripterygium hypoglaucum, possesses anti-inflammatory effects.
|
-
- HY-142982
-
-
- HY-13219
-
-
- HY-N10423
-
|
Cubebin
(-)-Cubebin
|
Others
|
Inflammation/Immunology
|
|
Cubebin is a dibenzylbutyrolactone lignan isolated from the crude hexane extract of the leaves of Zanthoxyllum naranjillo. Cubebin shows a significant anti-inflammatory activity.
|
-
- HY-N2601
-
-
- HY-N2276
-
|
Nodakenetin
|
Others
|
Inflammation/Immunology
|
|
Nodakenetin, isolated from Angelica decursiva, possesses antioxidant anti-inflammatory activities. Nodakenetin has the potential to be an antiarthritic and nerve tonic.
|
-
- HY-114454
-
|
INH14
|
IKK
|
Cancer
Inflammation/Immunology
|
|
INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. INH14 inhibits the IKKα/β-dependent TLR inflammatory response. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity.
|
-
- HY-N0631
-
|
Cornuside
|
p38 MAPK
NF-κB
|
Inflammation/Immunology
|
|
Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis Sieb. et Zucc., which is a traditional oriental medicine for treating inflammatory diseases and invigorating blood circulation. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Cornuside has anti-allergic effects in vivo and in vitro which suggests a therapeutic application of this agent in inflammatory allergic diseases.
|
-
- HY-10582S2
-
|
Flurbiprofen-13C,d3
dl-Flurbiprofen-13C,d3
|
COX
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Flurbiprofen- 13C,d3 is the 13C- and deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].
|
-
- HY-B0559
-
|
Nabumetone
BRL14777
|
COX
|
Inflammation/Immunology
Cancer
|
|
Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metabolite 6MNA.
|
-
- HY-N11011
-
|
Withaphysalin A
|
Others
|
Inflammation/Immunology
|
|
Withaphysalin A is a withanolide-type compound. Withaphysalin A can be obtained from the anti-inflammatory fraction of P. minima. Withaphysalin A can be used for the research of inflammation.
|
-
- HY-N0006
-
-
- HY-N4150
-
-
- HY-30235A
-
-
- HY-N6864
-
|
Isovanillic acid
3-Hydroxy-4-methoxybenzoic acid
|
Others
|
Inflammation/Immunology
|
|
Isovanillic acid (3-Hydroxy-4-methoxybenzoic acid) is a phenolic acid isolated from isolated from Scrophularia ningpoensis, with Anti-inflammatory activity.
|
-
- HY-B1597
-
-
- HY-N4068
-
-
- HY-N5043
-
-
- HY-N7630
-
-
- HY-N2055
-
-
- HY-13236
-
-
- HY-D0803
-
-
- HY-N5042
-
-
- HY-111927
-
|
Pilloin
|
Others
|
Cancer
Inflammation/Immunology
|
|
Pilloin, a flavonoid isolated from Marrubium cylleneum, exerts a cytotoxic action targeted at the transformed lymphoblasts. Pilloin also possesses anti-inflammatory activity.
|
-
- HY-N0105
-
-
- HY-N5007
-
|
Galgravin
|
Apoptosis
|
Cancer
|
|
Galgravin is an active compound in Nectandra megapotamica, with anti-inflammatory activity. Galgravin displays in vitro cytotoxic activity and induce apoptosis in leukemia cells.
|
-
- HY-107961
-
|
Diflorasone diacetate
|
Others
|
Inflammation/Immunology
|
|
Diflorasone diacetate is an anti-inflammatory steroid compound used as locally or topically agent. Diflorasone diacetate is being used for skin disorders to control corticosteroid-responsive dermatoses.
|
-
- HY-N7275
-
-
- HY-N0648
-
|
Monotropein
|
Others
|
Inflammation/Immunology
|
|
Monotropein is an iridoid glycoside isolated Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model.
|
-
- HY-N1380
-
-
- HY-N2423
-
-
- HY-126196
-
|
Lumirubin
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Lumirubin, a structural isomer of bilirubin, is the main photooxidative product formed during photoresearch for the research of neonatal jaundice, and has a certain pro-inflammatory effect.
|
-
- HY-B1754
-
|
Rimexolone
Org 6216; Rimexel
|
Others
|
Inflammation/Immunology
|
|
Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation.
|
-
- HY-139555
-
|
Zectivimod
|
LPL Receptor
|
Inflammation/Immunology
|
|
Zectivimod is a sphingosine-1-phosphate receptor agonist. Zectivimod can be used for the research of autoimmune diseases, chronic inflammatory diseases and immunoregulation disorders.
|
-
- HY-N5015
-
|
Rosmanol
|
COX
|
Inflammation/Immunology
Cancer
|
|
Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.
|
-
- HY-N5089
-
-
- HY-N0021
-
-
- HY-W012634
-
-
- HY-N3968
-
|
Goniothalamin
GTN; (R)-(+)-Goniothalamin
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Goniothalamin (GTN) is styryllactone with anticancer, anti-inflammatory, immunosuppressive properties. Goniothalamin induces cytotoxicity, DNA damage and apoptosis of a variety of cancer cell lines.
|
-
- HY-N0207
-
-
- HY-117586
-
-
- HY-N0558
-
|
Alnustone
|
Others
|
Inflammation/Immunology
|
|
Alnustone, a non-phenolic diarylheptanoid found in herbs and spices, is a constituent of Alpiniae Katsumada. Alnustone displays anti-emetic and anti-inflammatory activities.
|
-
- HY-115744
-
-
- HY-136718
-
|
CLEFMA
|
Apoptosis
|
Cancer
|
|
CLEFMA is a curcuminoid with antitumor activity. CLEFMA inhibits tumor growth is associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
|
-
- HY-14648S2
-
-
- HY-14648S1
-
-
- HY-Y0189S
-
|
Methyl Salicylate-d4
Wintergreen oil-d4
|
COX
|
Inflammation/Immunology
|
|
Methyl Salicylate-d4 is the deuterium labeled Methyl Salicylate[1]. Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products[2]. A systemic acquired resistance (SAR) signal in tobacco[3]. A topical nonsteroidal anti-inflammatory agent (NSAID). Methyl salicylate lactoside is a COX inhibitor[5].
|
-
- HY-152576
-
|
CB2R agonist 1
|
Cannabinoid Receptor
|
Inflammation/Immunology
|
|
CB2R agonist 1 is a selective ligand of cannabinoid receptor subtype 2 (CB2R) with an EC50 value of 0.56 µM. CB2R agonist 1 has high affinity and excellent selectivity for human CB2R and CB1R respectively. CB2R agonist 1 regulates the production of pro-inflammatory cytokines and anti-inflammatory cytokines and play an immunomodulatory role.
|
-
- HY-129143
-
|
Delphinidin-3-sambubioside chloride
Dp3‐Sam chloride
|
Others
|
Metabolic Disease
Inflammation/Immunology
|
|
Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated from Hibiscus sabdariffa L..
|
-
- HY-106216
-
-
- HY-N0370S
-
|
Bergapten-d3
5-Methoxypsoralen-d3
|
Cytochrome P450
Autophagy
|
Cancer
|
|
Bergapten-d3 is deuterium labeled Bergapten. Bergapten is a natural anti-inflammatory and anti-tumor agent. Bergapten is inhibitory towards mouse and human CYP isoforms.
|
-
- HY-N10809
-
-
- HY-101114
-
-
- HY-N8174
-
-
- HY-N2406
-
-
- HY-P99515
-
-
- HY-N5003
-
-
- HY-121851
-
|
Revaprazan
SB 641257
|
Proton Pump
|
Inflammation/Immunology
|
|
Revaprazan (SB 641257) is a reversible proton pump inhibitor with significant anti-inflammatory effects. Revaprazan can be used for chronic gastric inflammation research.
|
-
- HY-N2883
-
|
Salipurpin
Apigenin 5-glucoside
|
Others
|
Inflammation/Immunology
|
Salipurpin (Apigenin 5-glucoside) is a flavonoid compound isolated from the branches and leaves of Cephalotaxus fortunei, which has certain anti-inflammatory activity.
|
-
- HY-N0783
-
-
- HY-112675
-
-
- HY-N0575
-
-
- HY-132196
-
-
- HY-138558
-
-
- HY-13570A
-
-
- HY-107617
-
|
PTIQ
|
MMP
|
Neurological Disease
|
|
PTIQ can suppress MMP-3 production, can enter the brain and provide neuroprotection. PTIQ has anti-inflammatory effects on microglial cells.
|
-
- HY-N0153
-
-
- HY-W013332
-
-
- HY-N0037
-
-
- HY-W013573
-
-
- HY-17482
-
|
Difenpiramide
Z-876
|
Others
|
Inflammation/Immunology
|
|
Difenpiramide (Z-876) is a bisphenylalcanoic derivative with marked anti-inflammatory, analgesic, antipyretic and uricosuric properties. Difenpiramide has platelet anti-aggregation activity.
|
-
- HY-102040
-
|
Hispidol
(Z)-Hispidol
|
TNF Receptor
|
Inflammation/Immunology
|
|
Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 µM.
|
-
- HY-134602
-
-
- HY-N6020A
-
|
(+)-Butin
|
Others
|
Others
|
|
(+)-Butin is the R enantiomer of Butin. Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera, with strong antioxidant, antiplatelet and anti-inflammatory activities.
|
-
- HY-125711
-
-
- HY-139787A
-
|
Donidalorsen sodium
|
Others
|
Others
|
|
Donidalorsen (sodium) is an antisense oligonucleotide designed to reduce the production of prekallikrein (PKK). PKK plays an important role in the activation of inflammatory mediators associated with acute attacks of Hereditary angioedema (HAE).
|
-
- HY-17509S
-
-
- HY-N3500
-
-
- HY-W013332A
-
-
- HY-N9615
-
-
- HY-126941
-
|
Hecogenin acetate
|
Opioid Receptor
|
Neurological Disease
|
|
Hecogenin acetate is a steroidal sapogenin-acetylated with anti-inflammatory and antinociceptive. Hecogenin acetate shows potential antihyperalgesic activity, inhibiting descending pain and acting in opioid receptors.
|
-
- HY-119960
-
|
AHR-10037
|
COX
|
Inflammation/Immunology
|
|
AHR-10037 is a non-steroidal anti-inflammatory agent with low gastric toxicity. AHR-10037 is a prodrug converted in vivo to a cyclooxygenase inhibitor.
|
-
- HY-N1121
-
|
Triptonodiol
|
Others
|
Cancer
|
|
Triptonodiol can be isolated from Trypterygium wilfordii. Triptonodiol has anti-inflammatory and anti-cancer activity. Triptonodiol inhibits the biological activity of GSK.
|
-
- HY-30152
-
-
- HY-106579S
-
|
Tiaprofenic acid-d3
|
COX
|
Inflammation/Immunology
|
|
Tiaprofenic acid-d3 is a deuterium labeled Tiaprofenic acid. Tiaprofenic acid is a nonsteroidal anti-inflammatory agent (NSAID) mainly used in the treatment of rheumatic diseases[1].
|
-
- HY-N2074
-
|
Picrinine
|
Lipoxygenase
|
Inflammation/Immunology
|
|
Picrinine, an akuammiline alkaloid, is isolated from the leaves of Alstonia scholaris. Picrinine exhibits anti-inflammatory activity through inhibition of the 5-lipoxygenase enzyme.
|
-
- HY-13570
-
-
- HY-N7292
-
-
- HY-103662
-
-
- HY-150521
-
-
- HY-13751
-
-
- HY-W013812S
-
-
- HY-N0697
-
-
- HY-139787
-
|
Donidalorsen
|
Others
|
Others
|
|
Donidalorsen is an antisense oligonucleotide designed to reduce the production of prekallikrein (PKK). PKK plays an important role in the activation of inflammatory mediators associated with acute attacks of Hereditary angioedema (HAE).
|
-
- HY-128934
-
-
- HY-104026B
-
-
- HY-101737
-
-
- HY-N7697C
-
-
- HY-N2807
-
-
- HY-105656
-
|
Hydrocortisone phosphate sodium
Hydrocortisone 21-phosphate sodium; Cortisol 21-phosphate sodium
|
Others
|
Infection
|
|
Hydrocortisone phosphate sodium is a soft steroid with low anti-inflammatory properties and a short duration of action. Hydrocortisone phosphate sodium can be used for the research for several ocular conditions and gastric ulcers.
|
-
- HY-15382
-
-
- HY-132810
-
|
Bevurogant
BI 730357
|
ROR
|
Inflammation/Immunology
|
|
Bevurogant (BI 730357) is a retinoid-related orphan receptor-gamma t (RORγt) antagonist. Bevurogant can be used for the research of chronic inflammatory diseases.
|
-
- HY-N10672
-
-
- HY-14648S
-
-
- HY-129611
-
|
Bromelain
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Bromelain is an anti-inflammatory agent derived from pineapple stem that acts through down-regulation of plasma kininogen, inhibition of Prostaglandin E2 expression, degradation of advanced glycation end product receptors and regulation of angiogenic biomarkers as well as antioxidant action upstream in the COX-pathway. Bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death.
|
-
- HY-B1671
-
|
(+)-Kavain
|
GABA Receptor
Sodium Channel
Calcium Channel
|
Metabolic Disease
Neurological Disease
|
|
(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na + and Ca 2+ channels. (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied.
|
-
- HY-P99738
-
|
Mirococept
APT070
|
Complement System
|
Inflammation/Immunology
Cardiovascular Disease
|
|
Mirococept (APT070) is an antibody targeting to complement system C3b/C4b, as well as a membrane-localizing C3 convertase inhibitor. Mirococept reduces the release of C-peptide and pro-inflammatory cytokines, and reduces the infiltration of inflammatory cells. Mirococept reduces intraislet inflammation, which is beneficial to islet transplantation. Mirococept also inhibits increased intestinal and pulmonary vascular permeability to reduce neutrophil influx.
|
-
- HY-106481
-
|
Bufrolin
|
GPR35
Histamine Receptor
|
Inflammation/Immunology
|
|
Bufrolin is a Cromoglycate (histamine release inhibitor) analog and a high potency agonist of GPR35. Bufrolin promotes interactions between β-arrestin-2 and either human GPR35a or rat GPR35. Bufrolin also serves as antiallergic mast cell stabilizer and inhibit an anti-inflammatory response inducible by the internalization peptide. Bufrolin acts as an anti-inflammatory agent to be used in research of delivering pharmacol linked with internalization peptide.
|
-
- HY-N7697D
-
-
- HY-147963
-
|
COX-2-IN-24
|
COX
|
Infection
|
|
COX-2-IN-24 is an orally active inhibitor of COX-2 with IC50 value of 0.17 μM, shows anti-inflammatory and low ulcerogenic activities.
|
-
- HY-139199
-
|
4-Hydroxyphenylbutazone
|
Drug Metabolite
|
Others
|
|
4-Hydroxyphenylbutazone is a metabolite of Phenylbutazone. Phenylbutazone, a nonsteroidal anti-inflammatory agent (NSAID), is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS).
|
-
- HY-N0068
-
-
- HY-B1453
-
-
- HY-120541
-
-
- HY-121046S
-
|
Flunixin-d3
|
COX
|
Inflammation/Immunology
|
|
Flunixin-d3 is the deuterium labeled Flunixin. Flunixin Meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity[1][2].
|
-
- HY-N6020
-
|
(-)-Butin
|
Others
|
Inflammation/Immunology
|
|
(-)-Butin is the S enantiomer of Butin. Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera, with strong antioxidant, antiplatelet and anti-inflammatory activities.
|
-
- HY-U00157
-
|
Meseclazone
W2395; NSC297623
|
Others
|
Inflammation/Immunology
|
|
Meseclazone (W2395;NSC297623) exhibits inhibitory potency of secondary phase ADP aggregation. Meseclazone possesses anti-inflammatory, analgesic and antipyretic activity.
|
-
- HY-17492
-
-
- HY-W019940
-
-
- HY-N9315
-
-
- HY-N0023
-
|
Cistanoside A
|
NO Synthase
|
Inflammation/Immunology
|
|
Cistanoside A is a phenylethanoid isolated from Cistanche deserticola, reduces NO accumulation, but shows no effect on iNOS mRNA, iNOS protein levels or iNOS activity. Anti-inflammatory effect.
|
-
- HY-N4322
-
-
- HY-N1981S1
-
|
Triolein-d5
|
MMP
Endogenous Metabolite
|
|
|
Triolein-d5 is the deuterium labeled Triolein. Triolein is a symmetrical triacylglycerol, reduces MMP-1 upregulation, with strong antioxidant and anti-inflammatory properties[1].
|
-
- HY-Z0548
-
-
- HY-B1214S
-
-
- HY-B0367S
-
-
- HY-D1005A
-
|
Poloxamer 188
|
Biochemical Assay Reagents
|
Others
|
|
Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models.
|
-
- HY-137992
-
|
Aucuparin
|
Others
|
Inflammation/Immunology
|
|
Aucuparin, a natural product found in Sorbus aucuparia, inhibits pulmonary fibrosis in a bleomycin (BLM)-induced lung fibrosis mouse model. Anti-inflammatory activity.
|
-
- HY-145587
-
-
- HY-N7067
-
|
Revaprazan hydrochloride
|
Bacterial
COX
|
Infection
|
|
Revaprazan hydrochloride is a novel acid pump antagonist (APA). Revaprazan hydrochloride reduces COX-2 expression and has significant anti-inflammatory actions activities in H. pylori infection.
|
-
- HY-120541A
-
-
- HY-107470
-
-
- HY-N0493
-
-
- HY-126296
-
-
- HY-B0625S
-
-
- HY-12866B
-
-
- HY-12840
-
-
- HY-N0436
-
|
Engeletin
|
NF-κB
|
Infection
Inflammation/Immunology
|
|
Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb. , inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.
|
-
- HY-N7190
-
|
Yadanzioside F
|
Parasite
|
Cancer
|
|
Yadanzioside F is one of the toxic components found in Brucea javanica. Brucea javanica has demonstrated a variety of antitumoral, antimalarial, and anti-inflammatory properties.
|
-
- HY-N2149A
-
-
- HY-133807A
-
-
- HY-32343S
-
-
- HY-N2149
-
-
- HY-P99704
-
-
- HY-N10454
-
-
- HY-N0812
-
-
- HY-N0826
-
-
- HY-N10453
-
-
- HY-N0344
-
-
- HY-100891
-
-
- HY-12914
-
|
V116517
|
TRP Channel
|
Inflammation/Immunology
Neurological Disease
|
|
V116517 is a potent, orally active transient receptor potential vanilloid (TRPV1) antagonist. V116517 shows potent activity in inhibiting both capsaicin (CAP)- and acid (pH 5)-induced currents in rat DRG neurons expressing native TRPV (IC50=423.2 nM for CAP; IC50=180.3 nM for acid). V116517 can be used for the research of pain.
|
-
- HY-13988
-
|
AT-56
|
PGE synthase
|
Inflammation/Immunology
|
|
AT-56 is a potent, selective and orally active inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS), with an IC50 of 95 μM and Ki of 75 μM. AT-56 could selectively suppress the drowsiness or pain reaction mediated by L-PGDS-catalyzed PGD2.
|
-
- HY-112742
-
|
CP-195543
|
Leukotriene Receptor
|
Inflammation/Immunology
|
|
CP-195543 is a potent, selective and orally active leukotriene B4 (LTB4) receptor antagonist with IC50s of 6.8, 37.0 nM for human neutrophils and murine spleen membranes, respectively. CP-195543 blocks CD11b up-regulation. CP-195543 inhibits LTB4-mediated neutrophil infiltration.
|
-
- HY-103166
-
|
PSB-603
|
Adenosine Receptor
|
Inflammation/Immunology
|
|
PSB-603 is a potent and highly selective A2B adenosine receptor antagonist exhibiting a Ki value of 0.553 nM and virtually no affinity for the human and rat A1 and A2A and the human A3 receptors up to a concentration of 10 μM.
|
-
- HY-109148
-
|
Izencitinib
TD-1473; JNJ-8398
|
JAK
|
Inflammation/Immunology
|
|
Izencitinib (TD-1473) is an orally active, non-selective and gut-restricted JAK inhibitor. Izencitinib (TD-1473) can be used in the study for ulcerative colitis.
|
-
- HY-108908
-
-
- HY-12152
-
|
PNU-120596
NSC 216666
|
nAChR
|
Inflammation/Immunology
Neurological Disease
|
|
PNU-120596 (NSC 216666) is a potent and selective α7 nAChR positive allosteric modulator (PMA) with an EC50 of 216 nM. PNU-120596 is inactive against α4β2, α3β4, and α9α10 nAChRs. PNU-120596 has the potential for psychiatric and neurological disorders research.
|
-
- HY-144111
-
|
PPARα/δ agonist 1
|
PPAR
|
Inflammation/Immunology
|
|
PPARα/δ agonist 1 is a potent PPARα/PPARδ dual agonist (PPARα EC50=7.0 nM; PPARδ EC50=8.4 nM). PPARα/δ agonist 1 is a high selectivity over PPARγ (PPARγ EC50=1316.1 nM). PPARα/δ agonist 1 has the potential for the research of nonalcoholic steatohepatitis.
|
-
- HY-N11451
-
-
- HY-124557
-
-
- HY-103439
-
|
GW583340 dihydrochloride
|
EGFR
|
Cancer
|
|
GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50: 0.01 and 0.014 μM respectively). GW 583340 dihydrochloride reverses ABCG2- and ABCB1-mediated drug resistance. GW 583340 dihydrochloride has anti-cancer activity.
|
-
- HY-N3977
-
-
- HY-114654
-
|
Fusafungine
Bioparox; Fusaloyos; Locabiotal
|
Bacterial
Antibiotic
|
Inflammation/Immunology
|
|
Fusafungine (Bioparox; Fusaloyos; Locabiotal) is a potent and orally active antibiotic and anti-inflammatory agent. Fusafungine has the potential for the research of upper respiratory airways disease (URAD).
|
-
- HY-B0972
-
|
Cinchophen
|
Bacterial
|
Inflammation/Immunology
|
|
Cinchophen is a potent and orally active non-steroidal anti-inflammatory agent, has analgesic and antimicrobial effects. Cinchophen can be used for the research of arthritis and some liver diseases.
|
-
- HY-N6829
-
|
Retusin
Quercetin-3,3',4',7-tetramethylether
|
Antibiotic
|
Infection
Inflammation/Immunology
|
|
Retusin (Quercetin-3,3',4',7-tetramethylether), a natural compound isolated from the leaves of Talinum triangulare, possesses antiviral and anti-inflammatory activities.
|
-
- HY-N0399
-
-
- HY-151354
-
|
Antibacterial agent 121
|
Bacterial
|
Infection
|
|
Antibacterial agent 121 (Compound 10) is an antibacterial agent. Antibacterial agent 121 shows anti-mycobacterial and anti-inflammatory activities and can be used in Tuberculosis (TB) research.
|
-
- HY-N1469
-
-
- HY-113689
-
-
- HY-N0779A
-
|
Silybin
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity.
|
-
- HY-N6878
-
|
Cauloside D
|
NO Synthase
|
Inflammation/Immunology
|
|
Cauloside D is a triterpene glycoside isolated from Caulophyllum robustum Max. Cauloside D exerts anti-inflammatory effects through the inhibition of expression of iNOS and proinflammatory cytokines.
|
-
- HY-B0935
-
|
Benzyl benzoate
Benzoic acid benzyl ester
|
Parasite
Endogenous Metabolite
|
Infection
|
|
Benzyl benzoate (Benzoic acid benzyl ester) is a fragrance ingredient in cosmetic products. Benzyl benzoate can be used for the research of Scabies and Demodex-associated inflammatory skin conditions.
|
-
- HY-N0804
-
|
Narirutin
|
Bacterial
|
Inflammation/Immunology
|
|
Narirutin, one of the active constituents isolated from citrus fruits, has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tubercular potency.
|
-
- HY-U00347
-
-
- HY-N1429
-
-
- HY-N3245
-
-
- HY-N0795
-
-
- HY-N3103
-
-
- HY-W004294
-
-
- HY-N2518
-
-
- HY-13693S
-
-
- HY-B1832S
-
-
- HY-119259
-
|
AZD8309
|
CXCR
|
Inflammation/Immunology
|
|
AZD8309 is an orally active antagonist of CXCR2. AZD8309 has the ability to regulate the transmigration of neutrophils. AZD8309 can be used in the study of inflammatory diseases.
|
-
- HY-P1676
-
|
cyclo(RLsKDK)
BK-1361
|
MMP
|
Cancer
|
|
cyclo(RLsKDK) (BK-1361) is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. cyclo(RLsKDK) has potential applications in inflammatory diseases and cancer.
|
-
- HY-N1181
-
-
- HY-N0564
-
-
- HY-N4111
-
-
- HY-N2189
-
-
- HY-B1046
-
-
- HY-N2027
-
-
- HY-N6919
-
|
Cauloside C
|
NO Synthase
|
Inflammation/Immunology
|
|
Cauloside C is a triterpene glycoside isolated from Caulophyllum robustum Max. Cauloside C exerts anti-inflammatory effects through the inhibition of expression of iNOS and proinflammatory cytokines.
|
-
- HY-107632
-
-
- HY-W086896
-
-
- HY-13751A
-
-
- HY-N0708
-
-
- HY-N2958
-
|
Braylin
|
Phosphodiesterase (PDE)
|
Inflammation/Immunology
|
Braylin, a coumarin, is a potent phosphodiesterase-4 (PDE4) inhibitor and is involved in anti-inflammatory and immunomodulation, which may serve as a potential target for the study of immunoinflammatory diseases.
|
-
- HY-Y0148
-
-
- HY-145628
-
|
CM398
|
Sigma Receptor
|
Inflammation/Immunology
Neurological Disease
|
|
CM398 is a highly selective, orally active sigma-2 receptor ligand (Ki=0.43 nM), with high sigma-1/sigma-2 selectivity rato (1000-fold). CM398 shows notable affinity for dopamine (Ki=32.90 nM) and serotonin transporters (Ki=244.2 nM). CM398 shows promising anti-inflammatory analgesic effects in the formalin model of inflammatory pain in mice.
|
-
- HY-B0808A
-
|
Oxaprozin potassium
Oxaprozinum potassium; Wy21743 potassium
|
COX
NF-κB
Akt
IKK
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Oxaprozin potassium is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin potassium also inhibits the activation of NF-κB. Oxaprozin potassium induces cell apoptosis. Oxaprozin potassium shows anti-inflammatory activity. Oxaprozin potassium-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties.
|
-
- HY-115319
-
|
CP-24879 hydrochloride
|
Ferroptosis
|
Inflammation/Immunology
|
|
CP-24879 (hydrochloride) is a potent, selective and combined delta5D/delta6D inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research.
|
-
- HY-12383S
-
|
Pelubiprofen-13C,d3
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
Neurological Disease
|
|
Pelubiprofen- 13C,d3 is the 13C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects[1].
|
-
- HY-113509
-
|
Lipoxin A4
LXA4
|
Interleukin Related
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM.
|
-
- HY-B0808
-
|
Oxaprozin
Oxaprozinum; Wy21743
|
COX
NF-κB
Akt
IKK
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Oxaprozin is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties.
|
-
- HY-P99420
-
|
Acazicolcept
ALPN-101
|
CD28
|
Inflammation/Immunology
|
|
Acazicolcept (ALPN-101), an Fc fusion protein, is a dual inducible T cell costimulator (ICOS)/CD28 antagonist. Acazicolcept has anti-inflammatory activities.
|
-
- HY-N0635
-
-
- HY-P99331
-
|
Vepalimomab
Anti-Human AOC3 Recombinant Antibody
|
AP-1
|
Inflammation/Immunology
|
|
Vepalimomab (Anti-Human AOC3 Recombinant Antibody) is a monoclonal antibody that blocks vascular adhesion protein 1 (VAP-1). Vepalimomab has anti-inflammatory effects.
|
-
- HY-18342
-
|
Diflunisal
MK-647
|
COX
|
Inflammation/Immunology
Cancer
|
|
Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.
|
-
- HY-B1121
-
-
- HY-B1042
-
|
Oxolamine citrate
SKF-9976 citrate; AF-438 citrate
|
Others
|
Inflammation/Immunology
|
|
Oxolamine citrate (SKF-9976 citrate) is a cough suppressant that can be used for the research of respiratory tract diseases. Oxolamine citrate also exhibits anti-inflammatory effect.
|
-
- HY-139196
-
-
- HY-32291
-
|
Methyl L-pyroglutamate
(S)-Methyl 5-oxopyrrolidine-2-carboxylate; L-Pyroglutamic acid methyl ester
|
Others
|
Others
|
|
Methyl L-pyroglutamate ((S)-Methyl 5-oxopyrrolidine-2-carboxylate;L-Pyroglutamic acid methyl ester) is isolated from P. oleracea and has anti-inflammatory activity.
|
-
- HY-Y0073
-
|
4-Hydroxyacetophenone
P-hydroxyacetophenone
|
HBV
|
Infection
Inflammation/Immunology
|
|
4-Hydroxyacetophenone (P-hydroxyacetophenone) is a key hepatoprotective and choleretic compound in Artemisia capillaris and A. morrisonensis, also has an anti-hepatitis B virus effect and anti-inflammatory effect.
|
-
- HY-N6049
-
-
- HY-N0363
-
|
(+)-Columbianetin
(S)-Columbianetin
|
Fungal
|
Infection
Inflammation/Immunology
|
|
(+)-Columbianetin is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity.
|
-
- HY-17490
-
|
Oxaceprol
N-Acetyl-L-hydroxyproline
|
Amino Acid Derivatives
|
Inflammation/Immunology
|
|
Oxaceprol (N-Acetyl-L-hydroxyproline), an orally active derivative of L-proline, possesses distinct anti-inflammatory activity. Oxaceprol is usually used for the research of osteoarthritis and rheumatoid arthritis.
|
-
- HY-136203
-
-
- HY-113556
-
-
- HY-B0289
-
-
- HY-N1981S
-
-
- HY-N0114A
-
-
- HY-N10297
-
-
- HY-121362
-
-
- HY-108017
-
|
Ferric maltol
|
Others
|
Metabolic Disease
|
|
Ferric maltol is an orally active complex of a single ferric ion (Fe 3+). Ferric maltol has tha potential for iron deficiency anemia treatment in inflammatory bowel disease.
|
-
- HY-103386
-
|
FR122047
|
COX
|
Inflammation/Immunology
|
|
FR122047 (hydrochloride) is a selective and oral active inhibitor of COX-1 with an IC50 of 28 nM. FR122047 hydrochloride has antiplatelet, analgesic and anti-inflammatory effects in vivo.
|
-
- HY-N1823
-
-
- HY-N2281
-
-
- HY-N8096
-
|
Raddeanoside R17
Pulchinenoside E3
|
Others
|
Inflammation/Immunology
|
|
Raddeanoside R17 (Pulchinenoside E3) is a saponin compound that can be isolated from the root of Pulsatilla koreana. Raddeanoside R17 shows anti-inflammatory effects.
|
-
- HY-N2460
-
-
- HY-N1109
-
|
Uvaol
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Uvaol, a triterpene present in olives and virgin olive oil, possesses anti-inflammatory properties and antioxidant effects. Uvaol attenuates pleuritis and eosinophilic inflammation in ovalbumin-induced allergy in mice.
|
-
- HY-116933
-
-
- HY-122402
-
|
Umirolimus
|
Bacterial
|
Inflammation/Immunology
|
|
Umirolimus, a macrocyclic triene lactone Rapamycin derivative, is powerful immunosuppressant and anti-inflammatory agent. Umirolimus has highly lipophilicity and can be used agent-eluting stent (DES) applications.
|
-
- HY-136204
-
-
- HY-B1130
-
|
Isoxicam
|
COX
|
Inflammation/Immunology
|
|
Isoxicam is an orally active, long-acting, non-steroidal anti-inflammatory agent for the research of arthritis. Isoxicam is a nonselective inhibitor of COX-1 and COX-2.
|
-
- HY-122208
-
|
SGA360
|
Others
|
Inflammation/Immunology
|
|
SGA360 suppress inflammatory SAA1 signaling in an AHR-dependent manner through a mechanism that does not require AHR binding to its cognate response element (partial antagonist).
|
