1. MAPK/ERK Pathway
    Stem Cell/Wnt
    PI3K/Akt/mTOR
  2. JNK
    ERK
    mTOR
  3. Rutin hydrate

Rutin hydrate (Synonyms: Rutoside hydrate; Quercetin 3-O-rutinoside hydrate)

Cat. No.: HY-N0148A
Handling Instructions

Rutin hydrate is a flavonol glycoside, able to cross the blood-brain barrier, and acts by inhibiting JNK and ERK1/2 activation and activating mTOR signalling.

For research use only. We do not sell to patients.

Rutin hydrate Chemical Structure

Rutin hydrate Chemical Structure

CAS No. : 207671-50-9

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Based on 1 publication(s) in Google Scholar

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Description

Rutin hydrate is a flavonol glycoside, able to cross the blood-brain barrier, and acts by inhibiting JNK and ERK1/2 activation and activating mTOR signalling.

IC50 & Target

JNK

 

ERK1

 

ERK2

 

mTOR

 

In Vivo

Rutin hydrate (100 mg/kg) significantly lowers MDA levels and concomitantly increases glutathione (GSH), GSH/oxidized glutathione (GSSG) ratio, total glutathione levels and activities of GPx in the brain of rats. Rutin hydrate alone or in combination with a-tocopherol to CdCl2 intoxicated rats inhibits the declines in the levels of Ach and ChAT activity and significantly inhibited the activities of AChE. Rutin hydrate also inhibits neural apoptosis by inhibiting JNK activation in the brain of control and CdCl2 intoxicated rats and of ERK1/2 activation in the brain of CdCl2 intoxicated rats. In addition, Rutin hydrate activates mTOR/Akt in the brain of control and CdCl2 intoxicated rats[1].

Molecular Weight

740.26

Formula

C₂₇H₃O₁₆.₃₆/₅ H₂O

CAS No.

207671-50-9

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (67.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3509 mL 6.7544 mL 13.5088 mL
5 mM 0.2702 mL 1.3509 mL 2.7018 mL
10 mM 0.1351 mL 0.6754 mL 1.3509 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.38 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.38 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.38 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

Rats[1]
(1) A control group receives of 0.01 g/mL carboxymethylcellulose (CMC) dissolved in distilled water; (2) α-tocopherol acetate treated group: control rats receive α-tocopherol (120 IU/rat) diluted in 0.1 mL of coconut oil; (3) Rutin hydrate treated control group (control + Rutin hydrate): control rats receive Rutin hydrate (100 mg/kg); (4) CdCl2 intoxicated group receives CdCl2 at a final dose of 5 mg/kg to induce neurotoxicity; (5) CdCl2 + Rutin hydrate treated group (CdCl2 + Rutin hydrate) receives CdCl2 (5 mg/kg) and receives a coincided dose of Rutin hydrate (100 mg/kg body weight); (6) CdCl2 + Rutin hydrate + α-tocopherol acetate-treated group receives CdCl2 (5 mg/kg) and receives concomitant dose of Rutin hydrate (100 mg/kg) in conjugation with α-tocopherol acetate (120 IU/rat) that is diluted in 0.1 mL of coconut oil. All treatments are given by orogastric gavage with a polyethylene catheter PE 190 daily for 30 days[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

RutinRutosideQuercetin 3-O-rutinosideJNKERKmTORc-Jun N-terminal kinaseExtracellular signal regulated kinasesMammalian target of RapamycinInhibitorinhibitorinhibit

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Rutin hydrate
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HY-N0148A
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