1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Roxatidine Acetate Hydrochloride

Roxatidine Acetate Hydrochloride (Synonyms: HOE 760)

Cat. No.: HY-B0305A Purity: 98.08%
Handling Instructions

Roxatidine Acetate Hydrochloride (HOE 760) is a selective histamine H2 receptor antagonist, can be used for the research of gastric and duodenal ulcers. Roxatidine Acetate Hydrochloride can be rapidly converted to its active metabolite, roxatidine, by esterases in the small intestine, plasma, and liver.

For research use only. We do not sell to patients.

Roxatidine Acetate Hydrochloride Chemical Structure

Roxatidine Acetate Hydrochloride Chemical Structure

CAS No. : 93793-83-0

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Solution
10 mM * 1 mL in DMSO USD 85 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Estimated Time of Arrival: December 31
Solid
500 mg USD 77 In-stock
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1 g USD 130 In-stock
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5 g USD 370 In-stock
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Description

Roxatidine Acetate Hydrochloride (HOE 760) is a selective histamine H2 receptor antagonist, can be used for the research of gastric and duodenal ulcers. Roxatidine Acetate Hydrochloride can be rapidly converted to its active metabolite, roxatidine, by esterases in the small intestine, plasma, and liver[1].

IC50 & Target[1]

H2 Receptor

 

In Vitro

Roxatidine Acetate Hydrochloride (6.25  μM, 12.5 μM, and 25 μM; pre-treatment for 30 min) suppresses the PMACI-induced activation of p38 MAPK, but does not affect the phosphorylation of ERK or JNK. The total ERK 1/2, JNK, and p38 MAPK levels are unaffected by roxatidine in human mast-cells-1 (HMC-1) cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Roxatidine Acetate Hydrochloride (oral gavage; 20 mg/kg; single dose) inhibits Compound 48/80-increased TNF-α, IL-6, and IL-1β production and mRNA expression. Additionally, Roxatidine decreases the compound 48/80-induced degradation of procaspase-1 and appearance of the corresponding cleaved bands in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR male mice (6 weeks old)[1]
Dosage: 20 mg/kg
Administration: Oral gavage; 20 mg/kg; single dose
Result: Suppressed compound 48/80-induced allergic inflammation in anaphylactic animal model.
Molecular Weight

384.90

Formula

C19H29ClN2O4

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (129.90 mM; Need ultrasonic)

H2O : ≥ 50 mg/mL (129.90 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5981 mL 12.9904 mL 25.9808 mL
5 mM 0.5196 mL 2.5981 mL 5.1962 mL
10 mM 0.2598 mL 1.2990 mL 2.5981 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 140 mg/mL (363.73 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
References
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Roxatidine Acetate Hydrochloride
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HY-B0305A
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