Cat. No.: HY-N2050

1,3,5,8-Tetrahydroxyxanthone

(Synonyms: Desmethylbellidifolin)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) is a natural xanthone extracted from Swertia chirata. 1,3,5,8-Tetrahydroxyxanthone has antispasmodic effect and anti-inflammatory activity.

For research use only. We do not sell to patients.

Purity: 99.92%
CAS No.: 2980-32-7
Formula: C₁₃H₈O₆
Molecular Weight:260.20

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

1,3,5,8-Tetrahydroxyxanthone Chemical Structure

CAS No.: 2980-32-7

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Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
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Biological Activity

Description

1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) is a natural xanthone extracted from Swertia chirata. 1,3,5,8-Tetrahydroxyxanthone has antispasmodic effect and anti-inflammatory activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
C6	IC₅₀	>100 μM Compound: 8	Antiproliferative activity against rat C6 cells assessed as cell number after 48 hrs by crystal violet assay Antiproliferative activity against rat C6 cells assessed as cell number after 48 hrs by crystal violet assay	[PMID: 18406151]
HT-22	IC₅₀	2.5 μM Compound: 40	Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 36876904]
U-251	IC₅₀	>100 μM Compound: 8	Antiproliferative activity against human U251 cells assessed as cell number after 48 hrs by crystal violet assay Antiproliferative activity against human U251 cells assessed as cell number after 48 hrs by crystal violet assay	[PMID: 18406151]

In Vitro

1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) attenuates lipopolysaccharide-induced nitric oxide release and proinflammatory cytokine expression in RAW264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin; orally; 5, 10, 20 mg/kg; 12 days) can inhibit trinitrobenzenesulfonic acid (TNBS)-induced ulcerative colitis (UC), reducing inflammatory response and alleviate colon muscle spasm^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2980-32-7
Appearance Solid
Molecular Weight 260.20
Formula C₁₃H₈O₆
Color Light yellow to green yellow
SMILES

O=C1C2=C(OC3=C1C(O)=CC=C3O)C=C(O)C=C2O
Synonyms

Desmethylbellidifolin
Structure Classification
- Phenols
- Polyphenols
- Phenols
- Xanthones
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Journal Impact Factor

J Med Chem

Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases. [Abstract]

2023 Mar 23;66(6):4106-4130. PMID: 36876904

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (384.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.8432 mL

19.2160 mL

38.4320 mL

5 mM

0.7686 mL

3.8432 mL

7.6864 mL

10 mM

0.3843 mL

1.9216 mL

3.8432 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ni Y, et al. Desmethylbellidifolin From Gentianella acuta Ameliorate TNBS-Induced Ulcerative Colitis Through Antispasmodic Effect and Anti-Inflammation. Front Pharmacol. 2019 Sep 20;10:1104. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.8432 mL	19.2160 mL	38.4320 mL	96.0799 mL
	5 mM	0.7686 mL	3.8432 mL	7.6864 mL	19.2160 mL
	10 mM	0.3843 mL	1.9216 mL	3.8432 mL	9.6080 mL
	15 mM	0.2562 mL	1.2811 mL	2.5621 mL	6.4053 mL
	20 mM	0.1922 mL	0.9608 mL	1.9216 mL	4.8040 mL
	25 mM	0.1537 mL	0.7686 mL	1.5373 mL	3.8432 mL
	30 mM	0.1281 mL	0.6405 mL	1.2811 mL	3.2027 mL
	40 mM	0.0961 mL	0.4804 mL	0.9608 mL	2.4020 mL
	50 mM	0.0769 mL	0.3843 mL	0.7686 mL	1.9216 mL
	60 mM	0.0641 mL	0.3203 mL	0.6405 mL	1.6013 mL
	80 mM	0.0480 mL	0.2402 mL	0.4804 mL	1.2010 mL
	100 mM	0.0384 mL	0.1922 mL	0.3843 mL	0.9608 mL

Keywords

1,3,5,8-Tetrahydroxyxanthone

1 Cited Publications

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1,3,5,8-Tetrahydroxyxanthone

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Publications Citing Use of MedChemExpress (MCE) 1,3,5,8-Tetrahydroxyxanthone

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

1,3,5,8-Tetrahydroxyxanthone

Bioactive Compound Library Max

Bioactive Compound Library

Immunology/Inflammation Compound Library

Natural Product Library

Phenols Library

Traditional Chinese Medicine Active Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Human Metabolite Library

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Miao Ethnicity Medicine Compound Library

Tibetan Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Mass Spectrometry Human Metabolite Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) 1,3,5,8-Tetrahydroxyxanthone

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

1,3,5,8-Tetrahydroxyxanthone Related Classifications

HY-N2050 Related Classifications