1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. Cedrol

Cedrol (Synonyms: (+)-Cedrol; α-Cedrol)

Cat. No.: HY-N2071
Handling Instructions

Cedrol is a bioactive sesquiterpene, a potent competitive inhibitor of cytochrome P-450 (CYP) enzymes. Cedrol inhibits CYP2B6-mediated bupropion hydroxylase and CYP3A4-mediated midazolam hydroxylation with Ki of 0.9 μM and 3.4 μM, respectively. Cedrol also has weak inhibitory effect on CYP2C8, CYP2C9, and CYP2C19 enzymes. Cedrol is found in cedar essential oil and poetesses anti-septic, anti-inflammatory, anti-spasmodic, tonic, astringent, diuretic, sedative, insecticidal, and anti-fungal activities.

For research use only. We do not sell to patients.

Cedrol Chemical Structure

Cedrol Chemical Structure

CAS No. : 77-53-2

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Estimated Time of Arrival: December 31
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Estimated Time of Arrival: December 31
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Description

Cedrol is a bioactive sesquiterpene, a potent competitive inhibitor of cytochrome P-450 (CYP) enzymes. Cedrol inhibits CYP2B6-mediated bupropion hydroxylase and CYP3A4-mediated midazolam hydroxylation with Ki of 0.9 μM and 3.4 μM, respectively. Cedrol also has weak inhibitory effect on CYP2C8, CYP2C9, and CYP2C19 enzymes[1]. Cedrol is found in cedar essential oil and poetesses anti-septic, anti-inflammatory, anti-spasmodic, tonic, astringent, diuretic, sedative, insecticidal, and anti-fungal activities[2].

IC50 & Target

CYP2B6; CYP3A4; CYP2C8; CYP2C9; CYP2C19[1]

Molecular Weight

222.37

Formula

C₁₅H₂₆O

CAS No.

77-53-2

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Cedrol
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HY-N2071
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