Caspase 1

By Type:	Pan (10) Selective (4)
By Effects:	Inhibitors (17) Chemical (1)

Cat. No.	Product Name	Effect	Purity

HY-12305

Q-VD-OPh	Inhibitor	99.78%
Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 7 with an IC₅₀ of 48 nM and 25-400 nM for other caspases including caspase 1, 3, 8, 9, 10, and 12.

HY-13205

Belnacasan	Inhibitor	99.99%
Belnacasan (VX-765) is an orally bioactive prodrug of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with K_is of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively.

HY-P1001

Ac-DEVD-CHO	Inhibitor	98.66%
Ac-DEVD-CHO is a specific Caspase-3 inhibitor with a K_i value of 230 pM.

HY-16990

Ac-YVAD-cmk	Inhibitor
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects.

HY-111675

Ac-FLTD-CMK	Inhibitor	99.53%
Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor.

HY-P2617A

Ac-WEHD-AFC TFA		98.02%
Ac-WEHD-AFC TFA is a fluorogenic caspase-1 substrate.

HY-P2617

Ac-WEHD-AFC
Ac-WEHD-AFC is a fluorogenic caspase-1 substrate.

HY-P3761

Ac-Tyr-Val-Lys-Asp-aldehyde	Inhibitor
Ac-Tyr-Val-Lys-Asp-aldehyde is a caspase-1 inhibitor, can be used for disease research including anemia-associated to chronic diseases, chemotherapy-induced anemia and Diamond-Blackfan anemia.

HY-112226

VRT-043198	Inhibitor	98.05%
VRT-043198, the drug metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases.

HY-12412

ML132	Inhibitor	98.75%
ML132 (NCGC-00183434) is a selective caspase 1 inhibitor with an IC₅₀ of 34.9 nM.

HY-B1138

Fenbufen	Inhibitor	98.99%
Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects.

HY-W041489

Chelidonic acid	Inhibitor
Chelidonic acid is a component of Chelidonium majus L.

HY-101019

Ossirene	Inhibitor	≥98.0%
Ossirene (AS101), an immunomodulatory tellurium compound, is a potent IL-1β inhibitor.

HY-P0111

Z-WEHD-FMK	Inhibitor	≥98.0%
Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor.

HY-19676

Pralnacasan	Inhibitor	98.75%
Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active interleukin-1β converting enzyme (ICE, caspase 1) inhibitor with a K_i of 1.4 nM.

HY-153068

CZL55	Inhibitor
CZL55 is a caspase-1 inhibitor with an IC₅₀ value of 24 nM.

HY-P2616

Mca-YVADAP-Lys(Dnp)-OH	Chemical
Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2).

HY-136975

Caspase-3-IN-1	Inhibitor
Caspase-3-IN-1 (compound 11b) is a potent Caspase-3 inhibitor, with an IC₅₀ of 14.5 nM.

HY-120019A

Ac-YVAD-CHO acetate	Inhibitor
Ac-YVAD-CHO (L-709049) acetate is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human K_i values of 3.0 and 0.76 nM.

HY-120019

Ac-YVAD-CHO	Inhibitor
Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human K_i values of 3.0 and 0.76 nM.

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