1. NF-κB
    Apoptosis
  2. NF-κB
    Caspase
  3. Chelidonic acid

Chelidonic acid 

Cat. No.: HY-W041489 Purity: >97.0%
Handling Instructions

Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM.

For research use only. We do not sell to patients.

Chelidonic acid Chemical Structure

Chelidonic acid Chemical Structure

CAS No. : 99-32-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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  • Biological Activity

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Description

Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1[1]. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM[2].

IC50 & Target[1][2]

NF-κB

 

Caspase-1

 

Glutamate decarboxylase

1.2 μM (Ki)

In Vitro

Chelidonic acid dose-dependently decreases IL-6 production at 0.1-10 μM, inhibits expression of IL-6 mRNA at 1-10 μM[1].
Chelidonic acid (0.1-10 μM) decreases caspase-1 activation, nuclear NF-κB activation, and increases cytosol NF-κB activation[1].
Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM. Chelidonic acid does not promote formation of apoenzyme or react with free pyridoxal-P[2].

In Vivo

Chelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reaction induced by ovalbumin in mice[3].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
Molecular Weight

184.10

Formula

C₇H₄O₆

CAS No.

99-32-1

SMILES

O=C(C1=CC(C=C(C(O)=O)O1)=O)O

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >97.0%

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Product Name:
Chelidonic acid
Cat. No.:
HY-W041489
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Chelidonic acid

Cat. No.: HY-W041489