LM-021
Based on 1 Customer Validation
LM-021 is a coumarin-chalcone derivative with anti-aggregatory, antioxidant, neuroprotective and anti-inflammatory properties which suppresses nitric oxide (NO), IL-1β, IL-6, TNF-α production, CD68 antigen (CD68) and histocompatibility-2 (MHCII) expression. LM-021 also attenuates the increase of caspase 1 activity, lactate dehydrogenase release and ROS level. LM-021 can be used for neurological research.
For research use only. We do not sell to patients.
- Purity: 98.27%
- CAS No.: 1022282-98-9
- Formula: C20H17NO4
- Molecular Weight:335.35
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Caspase Isoforms
More
Biological Activity
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IL-1β |
IL-6 |
Caspase-1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
156.5 μg/mL
Compound: 8
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Cytotoxicity against Homo sapiens (human) K562 cells by Sulphorhodamine B assay
Cytotoxicity against Homo sapiens (human) K562 cells by Sulphorhodamine B assay
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10.1007/s00044-011-9694-1 |
LM-021 (10 μM, 8 h pre-treatment, 20 h with inflammation) effectively reduces the expression of NO, IL-1β, IL-6, NLRP3, GAL3, IBA1, CD68 and MHCII, accompanying with alleviation of the transformed morphology on mouse BV-2 microglia[1].
LM-021 (10 μM, 8 h) reduces the cellular oxidative stress and associated polyQ aggregation, as well as promoting neurite outgrowth in SH-SY5Y cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1022282-98-9
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Appearance Solid
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Molecular Weight 335.35
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Formula C20H17NO4
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Color Purple to dark purple
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SMILES
CN(C1=CC=C(C=C1)/C=C/C(C2=C(C3=CC=CC=C3OC2=O)O)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 2 mg/mL (5.96 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9820 mL | 14.9098 mL | 29.8196 mL | 74.5490 mL |
| 5 mM | 0.5964 mL | 2.9820 mL | 5.9639 mL | 14.9098 mL |
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