1. Apoptosis
  2. Caspase
  3. Pralnacasan

Pralnacasan (Synonyms: VX-740; HMR 3480)

Cat. No.: HY-19676
Handling Instructions

Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active interleukin-1β converting enzyme (ICE, caspase 1) inhibitor with a Ki of 1.4 nM. Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan has the potential for osteoarthritis and rheumatoid arthritis treatment.

For research use only. We do not sell to patients.

Pralnacasan Chemical Structure

Pralnacasan Chemical Structure

CAS No. : 192755-52-5

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Description

Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active interleukin-1β converting enzyme (ICE, caspase 1) inhibitor with a Ki of 1.4 nM. Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan has the potential for osteoarthritis and rheumatoid arthritis treatment[1][2].

IC50 & Target

Interleukin-1β converting enzyme

1.4 nM (Ki)

In Vivo

Pralnacasan (0 -50 mg/kg; oral gavage; twice a day; for 6 weeks; female Balb/c mice) treatment reduces joint damage. Pralnacasan treatment does not appear to affect the weight of the animals[1].

Animal Model: Female Balb/c mice induced with collagenase[1]
Dosage: 0 mg/kg, 12.5 mg/kg, 25 mg/kg and 50 mg/kg
Administration: Oral gavage; twice a day; for 6 weeks
Result: Significantly ameliorated the histopathological damage of the medial knee joint compartments.
Molecular Weight

523.54

Formula

C₂₆H₂₉N₅O₇

CAS No.

192755-52-5

SMILES

O=C([[email protected]@H]1CCCN2N1C([[email protected]@H](NC(C3=NC=CC4=C3C=CC=C4)=O)CCC2=O)=O)N[[email protected]@H](C5)[[email protected]](OCC)OC5=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PralnacasanVX-740HMR 3480VX740VX 740HMR3480HMR-3480CaspaseICEconvertingenzymewell-toleratedosteoarthritisIL-1βIL-18rheumatoidarthritisIFN-γInhibitorinhibitorinhibit

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