2. Apoptosis
  3. Caspase
  4. CZL80

CZL80, a brain-penetrable caspase-1 inhibitor with an IC50 of 0.01 μM, could be used in the study of febrile seizures and later enhanced epileptogenic susceptibility.

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CZL80 Chemical Structure

CZL80 Chemical Structure

CAS No. : 313482-91-6

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CZL80 Related Antibodies

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Description

CZL80, a brain-penetrable caspase-1 inhibitor with an IC50 of 0.01 μM, could be used in the study of febrile seizures and later enhanced epileptogenic susceptibility[1].

IC50 & Target[1].

Caspase-1

0.01 μM (IC50)

In Vivo

CZL80 (7.5 mg/kg, i.v., qod) markedly reduces neuronal excitability and incidence of FS generation, and, in adult mice, relieved later enhanced epileptogenic susceptibility[1].
CZL80 delayed-administration is a competent to attenuate the progressive neurological dysfunction induced by photothrombosis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice and Caspase-1 gene knockout (Caspase-1−/−) mice weighing 23-26 g (9-10 weeks old)[2].
Dosage: 10, 30 mg/kg/d, 7 days.
Administration: i.p.
Result: Rescued motor dysfunction after photothrombotic stroke in mice.
Animal Model: Mice pups of caspase-1 knockout (Casp1−/−, RRID:IMSR_JAX:004947) and littermate controls (wild-type [WT], Casp1+/+)[1].
Dosage: 0.0075, 0.075, 0.75 and 7.5 mg/kg (2% DMSO in saline), qod (every other day).
Administration: Intravenously injected.
Result: Reduced seizure incidence, prolonged seizure latency and increased threshold to FS generation in a dose-dependent manner.
Molecular Weight

366.39

Formula

C19H14N2O4S
CAS No.
SMILES

O=C(O)C1=CC=CC(NC(C2=CC=CC(NC(C3=CC=CS3)=O)=C2)=O)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility

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In Vivo:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

  • Protocol 1

    CZL80 is dissolved in mixed solvent (propylene glycol:ethanol:water=5:1:4)[2].

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CZL80 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CZL80313482-91-6CZL 80CZL-80CaspaseFebrile seizurecaspase-1,Inhibitorinhibitorinhibit

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