1. Apoptosis
    Metabolic Enzyme/Protease
  2. Caspase
    Cathepsin
  3. Z-WEHD-FMK

Z-WEHD-FMK 

Cat. No.: HY-P0111 Purity: 98.64%
Handling Instructions

Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Z-WEHD-FMK Chemical Structure

Z-WEHD-FMK Chemical Structure

CAS No. : 210345-00-9

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10 mM * 1 mL in DMSO USD 546 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 650 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis[1][2][4].

IC50 & Target[1][2]

Caspase-1

 

In Vitro

Z-WEHD-FMK (80 μM; 9 hours) elicits a near-complete blockage of C. trachomatis-induced cleavage of golgin-84 and increases GM130 expression in cells[1].
Z-WEHD-FMK (30 min before being exposed to E. piscicida) effectively inhibits 0909I E. piscicida induced ZF4 cells cytotoxicity and pyroptotic morphology. And in addition, it also inhibits the cytotoxicity induced by cytosolic LPS delivery[2].
Z-WEHD-FMK (20 μM;18-24 hours following Cr3+,Ni2+, and Co2+) significantly induces a decrease of 76% to 86% in IL-1β release with 200 to 400 ppm Cr3+, it also induces a decrease of 35% to 45% with 48 ppm Ni2+ or higher, Finally, this caspase-1 inhibitor induced a decrease with 6 ppm Co2+, down to a level below the detection threshold, and a decrease of 40% to 48% with 12 to 24 ppm Co2+ in bone marrow-derived macrophages (BMDM)[3].

Western Blot Analysis[1]

Cell Line: C. trachomatis- or mock-infected HeLa cells
Concentration: 80 μM
Incubation Time: 9 hours
Result: Increased golgin-84 and GM130 expression.

Cell Viability Assay[2]

Cell Line: Mycoplasma free-ZF4 cells
Concentration:
Incubation Time: 30 min before being exposed to E. piscicida
Result: Inhibited ZF4 cells cytotoxicity and pyroptotic morphology.
Molecular Weight

763.77

Formula

C₃₇H₄₂FN₇O₁₀

CAS No.

210345-00-9

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
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Keywords:

Z-WEHD-FMKCaspaseCathepsinCaspase-1Caspase-5apoptosiscathepsin BInhibitorinhibitorinhibit

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