210345-00-9
Chemical Structure
Z-WEHD-FMK
Synonym(s): Z-WE(OMe)HD(OMe)-FMK
- CAS No.: 210345-00-9
- Formula:C37H42FN7O10
- Molecular Weight:763.77
IUPAC Name: methyl (5S,8S,11S,14S)-11-((1H-imidazol-5-yl)methyl)-5-((1H-indol-3-yl)methyl)-14-(2-fluoroacetyl)-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate
InChIKey: NLZNSSWGRVBWIX-KRCBVYEFSA-N
SMILES: O=C(N[C@@H](CCC(OC)=O)C(N[C@H](C(N[C@H](C(CF)=O)CC(OC)=O)=O)CC1=CN=CN1)=O)[C@@H](NC(OCC2=CC=CC=C2)=O)CC3=CNC4=C3C=CC=C4
Biological Activity: Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis[1][2][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Z-WEHD-FMK | 98.0% | Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis. | ||||||||||||||||||||
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References
- [1]. Kamada S, et al. Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases.Cell Death Differ. 1997 Aug;4(6):473-8. [Content Brief]
- [2]. Yang D, et al. Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish.Nat Commun. 2018 Aug 3;9(1):3052. [Content Brief]
- [4]. Newman ZL, et al. CA-074Me protection against anthrax lethal toxin.Infect Immun. 2009 Oct;77(10):4327-36. [Content Brief]
